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Thromb Haemost 1966; 15(01/02): 238-251
DOI: 10.1055/s-0038-1649425
Originalarbeiten — Original Articles — Travaux Originaux
Schattauer GmbH

The Monoiodoacetate (MIA) Tolerance Test, a New Quantitative Method for the Fibrin Stabilizing Factor (Factor XIII) Assay

P Sigg
1   Coagulation Laboratory (Dr. F. Duckert) of the Department of Medicine (Head: Prof. Dr. F. Koller), University of Basle, Switzerland
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Publication History

Publication Date:
24 July 2018 (online)

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Summary

A new quantitative test for the fibrin stabilizing factor (FSF, factor XIII) determination is described. The test is based on the principle of the reversible inhibition of the FSF action by monoiodoacetate (MIA).

The definition of the MIA tolerance is given. The normal range is about 45. The MIA tolerance is studied under various conditions. No FSF free material is necessary for its performance.

 

  • References

  • 1 Bachmann F, Duckert F, Koller F. The Stuart-Prower Factor Assay and its Clinical Significance. Thrombos. Diathes. haemorrh. (Stuttg) 02: 24 1958;
    PubMedGoogle Scholar
  • 2 Beck E, Duckert F, Ernst M. The Influence of Fibrin Stabilizing Factor on the Growth of Fibroblasts in Vitro and Wound Healing. Thrombos. Diathes. haemorrh. (Stuttg) 06: 485 1961;
    PubMedGoogle Scholar
  • 3 Glauss A. Gerinnungsphysiologische Schnellmethode zur Bestimmung des Fibrinogens. Acta haemat. (Basel) 17: 4 1957;
    PubMedGoogle Scholar
  • 4 Duckert F, Jung E, Shmerling D. H. A Hitherto Undescribed Congenital Haemorrhagic Diathesis Probably Due to Fibrin Stabilizing Factor Deficiency. Thrombos. Diathes. haemorrh. (Stuttg) 05: 179 1960;
    PubMedGoogle Scholar
  • 5 Duckert F. Le diagnostic des coagulopathies. Röntgenu. Lab.-Prax 13: 652 1960;
    PubMedGoogle Scholar
  • 6 Duckert F, Flückiger P, Isenschmid H, Matter M, Vogel-Meng J, Koller F. A Modification of the Thromboplastin Generation Test. Acta haemat. (Basel) 12: 197 1954;
    CrossrefPubMedGoogle Scholar
  • 7 Geiger M, Duckert F, Koller F. Quantitative Bestimmungen von Factor VIII und IX bei Blutersippen. ö.Europ. Congr. Soc. Haemat. Springer; Heidelberg: 1956
    Google Scholar
  • 8 Ikkala E, Nevanlinna H. R. Congenital Deficiency of Fibrin Stabilizing Factor. Thrombos. Diathes. haemorrh. (Stuttg) 07: 567 1962;
    PubMedGoogle Scholar
  • 9 Josso F, Prou-Wartelle O, Alagille D, Soulier J. P. Le déficit congénital en facteur stabilisant de la fibrine (facteur XIII). Etudes sur deux cas. Nouv. Rév. franc. Hémat 04: 276 1964;
    PubMedGoogle Scholar
  • 10 Rappeler R. Das Verhalten von Faktor V im Serum unter normalen und p Uhologischen Bedingungen. Z. klin. Med 153: 103 1955;
    PubMedGoogle Scholar
  • 11 Koller F, Loeliger A, Duckert F. Experiments on a New Clotting Factor (Factor VII). Acta haemat. (Basel) 06: 1 1951;
    CrossrefPubMedGoogle Scholar
  • 12 Loki K, Lorand L. On the Solubility of Fibrin Clots. Science 108: 208 1948;
    PubMedGoogle Scholar
  • 13 Loewy A. G, Edsall I. T. Studies on the Formation of Urea-insoluble Fibrin. J. biol. Chem 211: 289 1954;
    PubMedGoogle Scholar
  • 14 Lüscher F. F. Ein fibrinstabilisierender Faktor aus Thrombozyten. Schweiz, med. Wschr 87: 1220 1957;
    PubMedGoogle Scholar
  • 15 Mandelli F. Sindrome Emorragica da Diffetto del Fattore Stabilizante Fibrinico di Laki e Lorand. Med. clin. sper 13: 175 1963;
    PubMedGoogle Scholar
  • 16 Masure R. Trouble congénital de l’hémostase associé à un déficit en Facteur Stabilisant de la Fibrine (F. S. F). Hémostase 03: 119 1963;
    PubMedGoogle Scholar
  • 17 Müller G. Personal communication. 1964
    PubMedGoogle Scholar
  • 18 Robbins K. C. A Study of the Conversion of Fibrinogen to Fibrin. Amer. J. Physiol 142: 581 1944;
    PubMedGoogle Scholar
  • 19 Shmerling D. H, Jung E, Duckert F. Eine neue familiäre Koagulopathie infolge Mangels an fibrinstabilisierendem Factor. Helv. paediat. Acta 15: 471 1960;
    PubMedGoogle Scholar
  • 20 Swigert S. t, Koppel J. L, Olwin J. H. Selective Inactivation of Fibrin Stabilizing Factor Contaminant in Fibrinogen. Nature (Lond) 198: 797 1963;
    CrossrefPubMedGoogle Scholar
  • 21 Sigg P. E, Duckert F. Ein neuer Test zur Bestimmung des fibrinstabilisierenden Faktors. Schweiz, med. Wschr 93: 1455 1963;
    PubMedGoogle Scholar
  • 22 Zollinger W. Familienuntersuchung beim kongenitalen F aktor VII-Mangel. Klaus - Stiftung 28: 5 1963;
    PubMedGoogle Scholar