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Thromb Haemost 1972; 28(03): 359-366
DOI: 10.1055/s-0038-1649019
Original Article
Schattauer GmbH

Studies on the Role of Fibrinolysis and Fibrinogen Degradation Products (FDP) in Analgesic Action of Morphine

Włodzimierz Buczko
1   Department of Pharmacology and the Radiobiological Research Centre, Medical School in Białystok
,
Konstanty Wiśniewski
1   Department of Pharmacology and the Radiobiological Research Centre, Medical School in Białystok
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Publication History

Publication Date:
29 June 2018 (online)

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Summary

The role of fibrinolysis and FDP in the analgesic action of morphine in mice and rats was studied. It was shown that during activation of blood fibrinolysis, both the accumulation of morphine in the brain tissue of rats and the clinical effect of this drug were increased. Similar results were observed after morphine given simultaneously with FDP obtained in vitro. The data from the analysis of FDP carried out on Sephadex G-25 Fine columns suggest that only FDP of molecular weight of about 10,000 potentiate the action of morphine; smaller peptides decreased the action of this drug.

 

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