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Synthesis 2012; 44(19): 3019-3026
DOI: 10.1055/s-0032-1316769
DOI: 10.1055/s-0032-1316769
paper
Synthesis of 4-Aryl-4-methyl- and 4,4-Dimethyl-4H-pyrrolo[2,1-c][1,4]benzothiazines by an Easy Five-Step Sequence Starting from 2-Sulfanylbenzenamines
Further Information
Publication History
Received: 26 June 2012
Accepted after revision: 23 July 2012
Publication Date:
21 August 2012 (online)
Abstract
A convenient process for the synthesis of 4-aryl-4-methyl- and 4,4-dimethyl-4H-pyrrolo[2,1-c][1,4]benzothiazines has been developed. Cyclization of 1-{2-[1-aryl(or methyl)ethenylsulfanyl]phenyl}pyrroles, which are readily obtained by an easy four-step sequence starting from commercially available 2-sulfanylbenzenamines, to the desired heterocycles can be effected in good to excellent yields on treatment with a catalytic amount of hydriodic acid.
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