TY - JOUR AU - Hilscher, Moira B.; Shah, Vijay H. TI - Neutrophil Extracellular Traps and Liver Disease SN - 0272-8087 SN - 1098-8971 PY - 2020 JO - Semin Liver Dis JF - Seminars in Liver Disease LA - EN VL - 40 IS - 02 SP - 171 EP - 179 ET - 2019/11/14 DA - 2020/04/30 KW - portal hypertension KW - cirrhosis KW - neutrophil AB - Neutrophil extracellular traps, or NETs, are heterogenous, filamentous structures which consist of extracellular DNA, granular proteins, and histones. NETs are extruded by a neutrophil in response to various stimuli. Although NETs were initially implicated in immune defense, subsequent studies have implicated NETs in a spectrum of disease processes, including autoimmune disease, thrombosis, and cancer. NETs also contribute to the pathogenesis of several common liver diseases, including alcohol-associated liver disease and portal hypertension. Although there is much interest in the therapeutic potential of NET inhibition, future clinical applications must be balanced against potential increased risk of infection. PB - Thieme Medical Publishers DO - 10.1055/s-0039-3399562 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0039-3399562 ER -