TY - JOUR AU - Gyárfás, Piroska; Gerencsér, János; Wade, Warren S.; Ürögdi, László; Novák, Zoltán; Meyer, S. Todd TI - Efficient Synthesis of 3,4-Disubstituted 7-Azaindoles Employing SEM as a Dual Protecting–Activating Group SN - 0936-5214 SN - 1437-2096 PY - 2019 JO - Synlett JF - Synlett LA - EN VL - 30 IS - 20 SP - 2273 EP - 2278 ET - 2019/11/06 DA - 2019/12/02 KW - heterocycles KW - aromatic substitution KW - 7-azaindole KW - ethers AB - An efficient method for nucleophilic aromatic substitution on 7-azaindoles has been developed. The reaction is facilitated by the unique dual influence of SEM as both protecting and activating group, permitting mild conditions and short reaction times that are compatible with sensitive functional groups. The method is suitable for the synthesis of a broad range of products, most notably ethers. PB - © Georg Thieme Verlag DO - 10.1055/s-0039-1690735 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0039-1690735 ER -