TY - JOUR AU - Foo, L C; Roshidah, I; Aimy, M B TI - Platelets of Habitual Smokers Have Reduced Susceptibility to Aggregating Agent SN - 0340-6245 SN - 2567-689X PY - 1991 JO - Thromb Haemost JF - Thrombosis and Haemostasis LA - EN VL - 65 IS - 03 SP - 317 EP - 319 DA - 2018/07/02 AB - Platelet aggregation to collagen, and productions of 6-ketoprostagltandin-F1-alpha and tromboxane 82 during aggregation were measured after an overnight fast, involving both food and cigarettros, in 19 clinically healthy habitual smokers (10 or more cigarettes/day) and 23 non-smokers receiving the same diet. The subjects (all males; ages == 21-30 years) were residents of a school hostel. Mean platelet aggregation was significantly lower in smokerr; than non-smokers (23.2 ohms vs 3L.5 ohmS, p < 0.005). Non-smokers had significantly higher mean concentration of 6-keto-prostaglandin-F1-alpha than smokers (109.8 pmol/1 vs 92.3 pmol/1, p < 0.05). The level of thromboxane B2 did not differ significerntly between the two groups. These observations suggest that the role of smokittg as a risk factor for ischaemic heart disease is unlikely to be related to a direct enhancement of aggregation. On the contrary, the observations seem to suggest that habitual smoking may directly reduce platelet aggregability. PB - Schattauer GmbH DO - 10.1055/s-0038-1648142 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0038-1648142 ER -