TY - JOUR AU - Zhou, Yun; Liu, Chunxiao; Wang, Lifeng; Han, Leng; Hou, Shicong; Bian, Qinghua; Zhong, Jiangchun TI - A Concise Enantioselective Synthesis of (S)-Preclamol via Asymmetric Catalytic Negishi Cross-Coupling Reaction SN - 0936-5214 SN - 1437-2096 PY - 2019 JO - Synlett JF - Synlett LA - EN VL - 30 IS - 07 SP - 860 EP - 862 ET - 2019/03/26 DA - 2019/04/08 KW - (S)-preclamol KW - enantioselective Negishi cross-coupling KW - cobalt KW - asymmetric synthesis KW - chiral drug AB - A novel, concise, and efficient enantioselective synthesis of (S)-preclamol (87% ee, 51% total yield) has been developed. The key steps of this synthetic approach included cobalt-catalyzed asymmetric catalytic cross-coupling of α-bromo ester with arylzinc and the reduction of chiral ester to diol with a tertiary carbon atom. Moreover, it was demonstrated that our enantioselective Negishi cross-coupling was a powerful tool to construct stereogenic benzylmethyl center in chiral drugs on a gram scale. PB - © Georg Thieme Verlag DO - 10.1055/s-0037-1611759 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0037-1611759 ER -