TY - JOUR AU - Gagnepain, Julien; Jeanmart, Stephane; Bonvalot, Damien; Jacob, Olivier; Lamberth, Clemens TI - Synthesis of Conformationally Locked and C-Linked Analogues of Imidazole-Based Ketene Dithioacetal Fungicides SN - 0936-5214 SN - 1437-2096 PY - 2019 JO - Synlett JF - Synlett LA - EN VL - 30 IS - 01 SP - 59 EP - 62 ET - 2018/12/03 DA - 2018/12/14 KW - dithiolane KW - imidazole KW - C14-demethylase inhibitor KW - fungicide AB - First examples with the unknown tricyclic 4,8b-dihydro-3aH-indeno[1,2-d][1,3]dithiole ring system have been prepared. Also, imidazoles linked in ring position 5 to a ketene dithioacetal and 1,3-dithiane derivatives with an exocyclic cyano- and imidazole-substituted C–C double bond are completely new. All these compounds are either conformationally locked, C-linked or six-ring analogues of the antifungal agent luliconazole. Synthesis and fungicidal activity of these sterol biosynthesis inhibitors are reported. PB - © Georg Thieme Verlag DO - 10.1055/s-0037-1610341 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0037-1610341 ER -