TY - JOUR AU - Kadwa, Ebrahim; Friedrich, Holger B.; Bala, Muhammad D. TI - Structural Identification of Products from the Chloromethylation of Salicylaldehyde SN - 0936-5214 SN - 1437-2096 PY - 2019 JO - Synlett JF - Synlett LA - EN VL - 30 IS - 01 SP - 44 EP - 48 ET - 2018/11/26 DA - 2018/12/14 KW - salicylaldehyde KW - chloromethylation KW - chloromethylsalicyl­aldehyde KW - crystal structure KW - hydroxymethylsalicylaldehyde KW - methylene­bissalicylaldehyde AB - In the functionalization of salicylaldehyde to give 5-(chloromethyl)salicylaldehyde, two byproducts [5-(hydroxymethyl)salicylaldehyde and 5,5′-methylenebis(salicylaldehyde)] were also isolated. ­Detailed characterizations and structural analyses of all three products by single-crystal X-ray diffraction, multinuclear NMR spectroscopy, high-resolution mass spectrometry, and IR spectroscopic techniques are presented and discussed. A strategy is presented for the preferential isolation of the two byproducts through column chromatography. PB - © Georg Thieme Verlag DO - 10.1055/s-0037-1610334 UR - http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0037-1610334 ER -