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Semin Thromb Hemost 2008; 34(2): 182-186
DOI: 10.1055/s-2008-1079258
© Thieme Medical Publishers

Use of Mouse Models to Study the Role of Tissue Factor in Tumor Biology

Rafal Pawlinski1 , Nigel Mackman2
  • 1Department of Immunology, The Scripps Research Institute, La Jolla, California
  • 2Division of Hematology/Oncology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina
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Publication History

Publication Date:
21 July 2008 (online)

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ABSTRACT

Tissue factor (TF) is the primary initiator of the coagulation cascade and plays an essential role in hemostasis. TF also contributes to many diseases, including cancer. The correlation between thrombosis and cancer has been recognized for more than a century. However, it is only in the past two decades that we have begun to understand the role of TF in tumor biology. TF expression is upregulated on both tumor and host cells in cancer patients as well as in the circulation. Clinical observations indicate a direct correlation between the levels of tumor cell TF expression and poor prognosis for cancer patients. The role of TF in tumor biology has been extensively studied using various mouse tumor models. It has been demonstrated that tumor cell TF contributes to tumor metastasis, growth, and angiogenesis. The role of host TF in tumor progression is less clear. Recently developed mouse models with altered levels of TF may be useful in further analysis of the role of host cell TF in cancer.

KEYWORDS

Tissue factor - tumor - mouse models - coagulation

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Nigel MackmanPh.D. 

Division of Hematology/Oncology, Department of Medicine, University of North Carolina

917 Mary Ellen Jones Bldg, 98 Manning Drive, CB#7035, Chapel Hill, NC 27599

Email: nigel_mackman@med.unc.edu