Semin Thromb Hemost 2007; 33(2): 196-202
DOI: 10.1055/s-2007-969034
Copyright © 2007 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Variable Response to Clopidogrel in Patients with Coronary Artery Disease

Tobias Geisler1 , Meinrad Gawaz1
  • 1Medizinische Klinik III, Universitätsklinikum Tübingen, Eberhard Karls-Universität Tübingen, Tübingen, Germany
Further Information

Publication History

Publication Date:
06 March 2007 (online)

ABSTRACT

Antiplatelet drug resistance is a multifactorial phenomenon that affects a large number of cardiovascular patients with symptomatic coronary artery disease. Although unique definitions for aspirin and clopidogrel resistance are missing, there is growing evidence for a clinical importance of response to antiplatelet therapy. The prevalence for aspirin and clopidogrel resistance has been reported to be between 5 and 30% in literature. Moreover, recent data suggest a high rate of dual antiplatelet drug resistance. Although there are convincing data about an association of aspirin resistance and clinical outcome, little is known about the clinical relevance of clopidogrel hyporesponsiveness. This article reviews the evidence for the clinical impact of antiplatelet drug resistance, with particular attention on the clinical outcome of clopidogrel low response according to current clinical data. Additional systematic studies are needed to evaluate the effects of alternative antiplatelet therapies in patients identified as low responders.

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Meinrad GawazM.D. 

Medizinische Klinik III, Universitätsklinikum Tübingen

Otfried-Müllerstr.10, 72076 Tübingen, Germany

Email: meinrad.gawaz@med.uni-tuebingen.de