Saccopetrins A and B, Two Novel γ-Lactones from Saccopetalum prolificum

Abstract

Two new γ-lactones, saccopetrin A (1) and saccopetrin B (2), together with 10 known compounds have been isolated from the roots of Saccopetalum prolificum. Their structures were established by spectroscopic and chemical methods. The absolute configuration of 1 was determined by chemical transformation and the Mosher method. Cytotoxic activities were evaluated against several different cell lines. Compound 2 exhibited stronger cytotoxic activities than 1 against KB and HCT-8 cell lines at a concentration of 10^-5 mol/L.

Key words

Annonaceae - Saccopetalum prolificum - acetogenin-γ-lactones - saccopetrin A - saccopetrin B

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