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Exp Clin Endocrinol Diabetes 2002; 110(2): 53-59
DOI: 10.1055/s-2002-23486
Review

© Johann Ambrosius Barth

Delay of growth and development in children with bronchial asthma, atopic dermatitis and allergic rhinitis

W. F. Baum1 , U. Schneyer2 , A. M. Lantzsch2 , E. Klöditz1
  • 1 Department of Paediatrics, Martin-Luther-University Halle-Wittenberg, Germany
  • 2 Department of Internal Medicine II, Martin-Luther-University Halle-Wittenberg, Germany
Further Information

Publication History

received 24 October 2000 first decision 23 January 2001

accepted 13 November 2001

Publication Date:
27 March 2002 (online)

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Summary

The elevated incidence of short stature (body height < x¯ - 2s), skeletal retardation and delayed puberty in children with bronchial asthma or atopic dermatitis is generally attributed to the severity of the disorder. However, a series of findings indicate a causal influence of the atopy and the existence of atopic skeletal retardation per se.

The observation that children with atopic disorders, whether bronchial asthma, atopic dermatitis or allergic rhinitis, exhibit a rate of short stature that is twice to five times higher than normal indicates atopic and thus genetically determined influences. The elevated prevalence of short stature associated with allergic rhinitis is especially significant, as this disorder cannot be included among the severe chronic disorders. The fact that skeletal retardation is more prevalent in boys than in girls by a ratio of about 2 : 1 and that a significantly more marked retardation of bone maturation is found in atopic in comparisons with non-atopic asthmatics also lend support to this postulation. The clinical relevance of atopic growth retardation is also supported by the close interaction of pathophysiological basal mechanisms of bone metabolism and the atopy status. Thus the local growth factor prostaglandin E2 (PGE2), which is important for bone metabolism, is also a messenger substance for the immediate and late allergic reaction. The platelet-activating factor (PAF), as one of the strongest mediators in the pathogenesis of allergic disorders, influences the PGE2 synthesis in the osteoblasts. These relationships show that atopy-dependent imbalances in the complex system of local and systemic growth factors can certainly lead to disturbance of skeletal maturation which may delay growth and development in atopic children. In order to verify these assumptions it is necessary to research the interaction of local growth factors (particularly the roles of PGE2, PAF and IGF I) in the skeletons of children of short stature suffering from atopic disorders.

This should also include the possible effects on the overall hormonal factors influencing bone maturation. Atopy should be included in the differential diagnosis programme to clarify growth and development disturbances.

Key words:

Atopy - Short stature - Bronchial asthma - Atopic dermatitis - Allergic rhinitis - Skeletal retardation - Delayed puberty

References

  • 1 Abrahamov A, Schifmann R, Goldstein R, Tal Y, Freier S. Growth failure due to protein loss in dermatitis.  Eur J Pediatr. 1986;  145 223-226
    CrossrefPubMedGoogle Scholar
  • 2 Agertoft L, Pedersen S. Effekt of long-term treatment with inhaled budesonide on adult height in children with asthma.  N Engl J Med. 2000;  343 1064-1069
    CrossrefPubMedGoogle Scholar
  • 3 Allen D B, Mullen M, Mullen B. A meta-analysis of the effect of oral and inhaled corticosteroids on growth.  J Allergy Clin Immunol. 1994;  83 196-199
    PubMedGoogle Scholar
  • 4 Amirav I, Dowdeswell R J, Plit M, Panz V R, Joffe B I, Seftel H C. Growth hormone response to exercise in asthmatic and normal children.  Eur J Pediatr. 1990;  149 443-446
    PubMedGoogle Scholar
  • 5 Aoki T, Kushimoto H, Kobsayashi E, Ogushi Y. Computer analysis of nocturnal scratch in atopic dermatitis.  Acta Derm Venerol. 1980;  92 ((Suppl 92)) 33-37
    PubMedGoogle Scholar
  • 6 Balfour-Lynn L. Effect of asthma on growth and puberty.  Pediatrician. 1987;  14 237-241
    PubMedGoogle Scholar
  • 7 Balfour-Lynn L. Growth and childhood asthma.  Arch Dis Child. 1986;  61 1049-1055
    PubMedGoogle Scholar
  • 8 Barnes P J. New conceps in the pathogenesis of bronchial hyperresponsiveness and asthma.  J Allergy Clin Immunol. 1989;  83 1013-1026
    CrossrefPubMedGoogle Scholar
  • 9 Baum W F, Klöditz E, Brömme W, Bismarck M, Thiemann H H, Weingärtner R. Der Einfluß des Asthma bronchiale auf Wachstum und körperliche Entwicklung.  Ärztl Jugendkd. 1990;  81 379-383
    PubMedGoogle Scholar
  • 10 Baum W F, Klöditz E, Hesse J, Jahreis G, Schneyer U, Giebler H. Steigerung der spontanen Wachstumshormon-Sekretion bei asthmakranken Kindern - ein Symptom der atopischen Disposition?.  Kinderärztl Praxis. 1993 a;  61 323-328
    PubMedGoogle Scholar
  • 11 Baum W F, Klöditz E, Thiemann H H. Die atopische Skelettretardierung als eine mögliche Ursache für Kleinwuchs und Brustkorbdeformierung asthmakranker Kinder.  Kinderärztl Praxis. 1993 b;  61 285-290
    PubMedGoogle Scholar
  • 12 Bichell D P, Rotwein P, McCarthy T L. Prostaglandin E2 rapidly stimulates insulin-like growth factor-I gene expression in primary rat osteoblast cultures: evidence for transcriptional control.  Endocrinol. 1993;  133 1020-1028
    CrossrefPubMedGoogle Scholar
  • 13 Boot A M, deJongste J C, Verberne A A, Pols H A, de Muinck-Keizer-Schrama S M. Bone mineral density and bone metabolism of prepubertal children with asthma after long term treatment with inhaled corticosteroids.  Pediatr Pulmonol. 1997;  24 379-384
    CrossrefPubMedGoogle Scholar
  • 14 Brämswig J H. Kleinwuchs und Wachstumsstörungen. In: Allolio B, Schulte HM (eds.). Praktische Endokrinologie Urban-Schwarzenberg, München, Wien, Baltimore 1996: 92-110
    Google Scholar
  • 15 Buckley R H, Wray B B, Belmaker E Z. Extreme hyperimmunoglobinemia E and undue susceptibility to infection.  Pediatrics. 1972;  49 59-70
    PubMedGoogle Scholar
  • 16 Catteral J R, Douglas N J, Calverley P MA, Brash H M, Brezinova V, Sharpiro C M, Flenley D C. Irregular breathing and hypoxaemia during sleep in chronic stable asthma.  Lancet. 1982;  8267 301-304
    PubMedGoogle Scholar
  • 17 Chan S C, Kim J W, Henderson W R, Hanifin J M. Altered prostaglandin E2 regulation of cyticine production in atopic dermatitis.  J Immunol. 1993;  151 3345-3352
    PubMedGoogle Scholar
  • 18 Chang K C, Miklich D R, Barwise G, Chai H, Lawrence R M. Linear growth of chronic asthmatic children: the effects of the disease and various forms of steroid therapy.  Clin Allergy. 1982;  12 369-378
    PubMedGoogle Scholar
  • 19 Cogswell J J, El-Bishti M M. Growth retardation in asthma: role of calorie deficiency.  Arch Dis Child. 1982;  57 473-475
    PubMedGoogle Scholar
  • 20 Cohen M B, Weller R R, Cohen S. Anthropometry in children: progress in allergic children as shown by increments in height, weight and maturity.  Am J Dis Child. 1940;  60 1058-1066
    PubMedGoogle Scholar
  • 21 Crowley S, Hindmarsch P C, Matthews D R, Brook C GD. Growth and the growth hormone axis in prepubertal children with asthma.  J Pediatr. 1995;  126 297-303
    PubMedGoogle Scholar
  • 22 Crowley S, Trivedi P, Risteli L, Hindmarsh P C, Brook C G. Collagen metabolism and growth in prepubertal children with asthma treated with inhaled steroids.  J Pediatr. 1998;  132 409-413
    PubMedGoogle Scholar
  • 23 Däumling S, Buriot D, Huu Trung P, Griscelli C, Lalama M C, Belohradsky B H. Das Buckley-Syndrom: Rezidivierende schwere Staphylokokkeninfektionen Ekzem und Hyperimmunglobulinämie E.  Infection. 1980;  8 ((Suppl 3)) 248-254
    CrossrefPubMedGoogle Scholar
  • 24 David T J, Ferguson A P, Newton R W. Nocturnal growth hormone release in children with short stature and atopic dermatitis.  Acta Derm Venerol. 1991;  71 229-231
    PubMedGoogle Scholar
  • 25 David T J, Waddington E, Stanton R HJ. Nutritional hazards of elimination diets in children with atopic dermatitis.  Arch Dis Child. 1984;  59 323-325
    PubMedGoogle Scholar
  • 26 Decanay E P, van Metre T E. Suppression of asthma, weight gain, and linear growth in children receiving fluprednisolone.  J Allergy Clin Immunol. 1962;  33 259-270
    PubMedGoogle Scholar
  • 27 Eastman C J, Lazarus L. Growth hormone release during sleep in growth retarded children.  Arch Dis Child. 1973;  48 502-507
    PubMedGoogle Scholar
  • 28 Estelle F, Simons R. A comparison of beclomethasone, salmeterol, and placebo in children with asthma.  N Engl J Med. 1997;  337 1659-1665
    CrossrefPubMedGoogle Scholar
  • 29 Falliers C J, Szentivanyi J, McBride M, Bukantz S C. Growth rate of children with intractable asthma: observations on the influence of the illness and its therapy with steroids.  J Allergy. 1961;  32 420-434
    PubMedGoogle Scholar
  • 30 Falliers C J, Tan L S, Szentivanyi J, Jorgensen J R, Bukantz S C. Childhood asthma and steroid therapy as influences on growth.  Am J Dis Child. 1963;  105 127-137
    PubMedGoogle Scholar
  • 31 Ferguson A C, Murray A B, Tze W J. Short stature and delayed skeletal maturation in children with allergic disease.  J Allergy Clin Immunol. 1982;  69 461-466
    PubMedGoogle Scholar
  • 32 Flanagan A M, Chambers T J. Stimulation of bone nodule formation in vitro by prostaglandins E1 and E2.  Endocrinology. 1992;  130 443-448
    CrossrefPubMedGoogle Scholar
  • 33 Goldey D H, Mansmann H C, Rasmussen A I. Zinc status of asthmatic, prednisone-treated astmatic, and non-asthmatic children.  J Am Diet Assoc. 1984;  84 157-163
    PubMedGoogle Scholar
  • 34 Hauspie R, Susanne C, Alexander F. A mixed longitudinal study of the growth in height an weight in asthmatic children.  Hum Biol. 1976;  48 271-283
    PubMedGoogle Scholar
  • 35 Hauspie R, Susanne C, Alexander F. Maturational delay and temporal growth retardation in asthmatic boys.  J Allergy Clin Immunol. 1977;  59 200-206
    CrossrefPubMedGoogle Scholar
  • 36 Hesse V. Wachstum und Reifung. In: Meng W, Ziegler R (eds.). Endokrinologie 1. Auflage Gustav Fischer, Jena, Stuttgart, Lübeck, Ulm 1997: 105-131
    Google Scholar
  • 37 Jee W S, Kee H Z, Li X J. Long-term anabolic effects of prostaglandin-E2 on tibial diaphyseal bone in male rats.  Bone-Miner. 1991;  15 33-55
    PubMedGoogle Scholar
  • 38 Kales A, Kales J D, Sly R M, Scherf M B, Tan T L, Preston T A. Sleep patterns of asthmatic children: allnight electroencephalographic studies.  J Allergy Clin Immunol. 1970;  46 300-308
    PubMedGoogle Scholar
  • 39 Ke H Z, Jee W S, Mori S, Li X J, Kimmel D B. Effects of long-term daily administration of prostaglandin-E2 on maintaining elevated proximal tibial metaphyseal cancellous bone mass in male rats.  Calcif Tissue Int. 1992;  50 245-252
    CrossrefPubMedGoogle Scholar
  • 40 Kerrebijn K F, De Kroon J PM. Effects on height of corticosteroid therapy in asthmatic children.  Arch Dis Child. 1968;  43 556-561
    PubMedGoogle Scholar
  • 41 Klein G L, Dungy C I, Galant S P. Growth and the nutritional status of nonsteroid-dependent asthmatic-children.  Ann Allergy. 1991;  67 80-84
    PubMedGoogle Scholar
  • 42 Klein G, Duriseti L, Miyamoto S, Wright D, Galant S P. Nutrition and growth in the nonsteroid-dependent asthmatic child.  J Allergy Clin Immunol. 1978;  61 158-159
    PubMedGoogle Scholar
  • 43 Klein-Nulend J, Pilbeam C C, Raisz L G. Effect of 1.25-dihydroxyvitamin D3 on prostaglandin E2 production in cultured mouse parietal bones.  J Bone Miner Res. 1991;  6 1339-1344
    PubMedGoogle Scholar
  • 44 Kristmundsdottir F, David T J. Growth impairment in children with atopic eczema.  J R Soc Med. 1987;  80 9-12
    PubMedGoogle Scholar
  • 45 Lantzsch A M. Anthropometrische Untersuchungen bei Kindern mit atopischer Dermatitis - ein Beitrag zum Phänomen atopiebedingter Wachstumsstörungen. Halle Univ Med Fak Dissertation 2000
    Google Scholar
  • 46 Lewis R A, Robin J L. Arachidonic acid derivatives as mediators of asthma.  J Allergy Clin Immunol. 1985;  76 259-264
    CrossrefPubMedGoogle Scholar
  • 47 Maiello N, Del Guidice M M, Marano C, Capristo A, Salzano V. Rilievi sulla maturazione schelectrica e sull accrescimento staturale in bambini asmatici in rapporto alla terapia cortisonica.  Pediatria. 1980;  88 61-80
    PubMedGoogle Scholar
  • 48 Martin A J, Landau L I, Phelan P D. The effect on growth of childhood asthma.  A Pediatr Scand. 1981;  70 683-688
    PubMedGoogle Scholar
  • 49 Massarano A A, Hollis S, Devlin J, David T J. Growth in atopic eczema.  Arch Dis Child. 1993;  68 677-679
    PubMedGoogle Scholar
  • 50 McCarthy T L, Centrella M, Raisz L G, Canalis E. Prostaglandin E2 stimulates insulin-like growth factor I synthesis in osteoblast-enriched cultures from fetal rat bone.  Endocrinology. 1991;  128 2895-2900
    PubMedGoogle Scholar
  • 51 McNicol K N, Williams H B. Spectrum of asthma in children. - I. Clinical and physiological components.  Br Med J. 1973;  4 7-11
    PubMedGoogle Scholar
  • 52 Metre van T E, Niermann W A, Rosen L J. A comparison of the growth suppressive effect of cortisone, prednisone, and other adrenal cortical hormones.  J Allergy Clin Immunol. 1960;  31 531-542
    PubMedGoogle Scholar
  • 53 Metre van T E, Pinkerton H L. Growth suppression in asthmatic children receiving prolonged therapy with prednisone and methylprednisolone.  J Allergy. 1959;  30 103-113
    PubMedGoogle Scholar
  • 54 Monti J M, Vignale R, Monti D. Sleep and nighttime pruritus in children with atopic dermatitis.  Sleep. 1989;  12 309-314
    PubMedGoogle Scholar
  • 55 Morris H G. Growth and skeletal maturation in asthmatic children: effect of corticosteroid treatment.  Pediatr Res. 1975;  9 579-583
    PubMedGoogle Scholar
  • 56 Morris H G, Jorgensen J R, Jenkins S A. Plasma growth hormone concentration in corticoid-treated children.  J Clin Invest. 1968;  47 427-435
    PubMedGoogle Scholar
  • 57 Murray A B, Fraser B M, Hardwick D F, Pirie G E. Chronic asthma and growth failure in children.  Lancet. 1976;  7978 197-198
    PubMedGoogle Scholar
  • 58 Nigam P, Laungia L, Goyal G, Dutt B. Growth hormone secretion in growth retarded asthmatic children.  Indian J Pediatr. 1977;  44 315-319
    PubMedGoogle Scholar
  • 59 Norjavaara E, Gerhardsson-De-Verdier M, Lindmark B. Reduced height in swedish men with asthma at the age of conscription for military service.  J Pediatr. 2000;  137 25-29
    CrossrefPubMedGoogle Scholar
  • 60 O'Keefe R J, Crabb I D, Puzas J E, Rosier R N. Influence of prostaglandins on DNA and matrix synthesis in growth plate chondrocytes.  J Bone Miner Res. 1992;  7 397-404
    PubMedGoogle Scholar
  • 61 Oberger E, Engstrom I, Karlberg J. Long-term treatment with glucocorticoids/ACTH in asthmatic children. III. Effects on growth and adult height.  A Pediatr Scand. 1990;  79 77-83
    PubMedGoogle Scholar
  • 62 Pash J M, Delany A M, Adamo M L, Roberts C T, Leroith D, Canalis E. Regulation of insulin-like growth factor I transcription by prostaglandin E2 in osteoblast cells.  Endocrinology. 1995;  136 33-38
    CrossrefPubMedGoogle Scholar
  • 63 Patel L, Clayton P E, Addisoon G M, Price D A, David T J. Linear growth in prepubertal children with atopic dermatitis.  Arch Dis Child. 1998;  79 169-172
    PubMedGoogle Scholar
  • 64 Patel L, Clayton P E, Jenney M EM, Ferguson J E, David T J. Adult height in patients with childhood onset atopic dermatitis.  Arch Dis Child. 1997;  76 505-507
    PubMedGoogle Scholar
  • 65 Pike M G, Chang C L, Atherton D J, Carpenter R G, Preece M A. Growth in atopic eczema: a controlled study by questionnaire.  Arch Dis Child. 1989;  64 1566-1569
    PubMedGoogle Scholar
  • 66 Power C, Manor O. Asthma, enuresis, and chronic illness: long term impact on height.  Arch Dis Child. 1995;  73 298-304
    PubMedGoogle Scholar
  • 67 Preece M A, Law C M, Davies P SW. The growth of children with chronic paediatric disease.  Clin Endocrinol. 1993;  15 453-477
    PubMedGoogle Scholar
  • 68 Raisz L G, Fall P M, Gabbitas B Y, McCarthy T L, Kream B E, Canalis E. Effects of prostaglandin E2 on bone formation in cultured fetal rat calvariae: role of insulin-like growth factor-I.  Endocrinol. 1993 a;  133 1504-1510
    CrossrefPubMedGoogle Scholar
  • 69 Raisz L G, Fall P M, Petersen D N, Lichtler A, Kream B E. Prostaglandin E2 inhibits alpha 1 (I) procollagen gene transcription and promoter activity in the immortalized rat osteoblastic clonal cell line Py 1a.  Mol Endocrinol. 1993 b;  7 17-22
    CrossrefPubMedGoogle Scholar
  • 70 Raisz L G, Pilbeam C C, Fall P M. Prostaglandins: Mechanisms of action and regulation of production in bone.  Osteoporosis Int. 1993 c;  3 ((Suppl 1)) 136-140
    CrossrefPubMedGoogle Scholar
  • 71 Saha M T, Laippala P, Lenko H L. Growth of asthmatic children is slower during than before treatment with inhaled gluccocorticoids.  Acta Paediatr. 1997;  86 138-142
    PubMedGoogle Scholar
  • 72 Sanders S S, Norman A P. Growth hormone secretion in growth-retarded asthmatic children.  Br Med J. 1969;  3 25-26
    PubMedGoogle Scholar
  • 73 Schmid C, Schlapfer I, Waldvogel M, Zapf J, Froesch E R. Prostaglandin E2 stimulates synthesis of insulin-like growth factor binding protein-3 in rat bone cells in vitro.  J Bone Miner Res. 1992;  7 1157-1163
    PubMedGoogle Scholar
  • 74 Schwartz Z, Swain L D, Kelly D W, Brooks B, Boyan B D. Regulation of prostaglandin E2 production by vitamin D metabolites in growth zone and resting zone chondrocyte cultures is dependent on cell maturation.  Bone. 1992;  13 395-401
    CrossrefPubMedGoogle Scholar
  • 75 Seyberth H W, Leonhardt A, Soergel M. Das Hyperprostaglandin-E2-Syndrom.  Monatsschr Kinderheilk. 1994;  142 392-395
    PubMedGoogle Scholar
  • 76 Shibata Y, Ogura N, Moriya Y, Abiko Y, Izumi H, Takiguchi H. Platelet-activating factor stimulates production of prostaglandin E2 in murine osteoblast-like cell line MC3T3-E1.  Life Sci. 1991;  49 1103-1109
    CrossrefPubMedGoogle Scholar
  • 77 Silverstein M D, Yunginger J W, Reed C E, Petterson T, Zimmermann C, Li J T, Fallon W M. Attained adult height after childhood asthma: Effect of glucocorticoid therapy.  J Allergy Clin Immunol. 1997;  99 466-474
    PubMedGoogle Scholar
  • 78 Skoner D P, Rachelefsky G S, Meltzer E O, Chervinsky P, Morris R M, Seltzer J M, Storms W W. Detection of growth suppression in children during treatment with intranasal beclomethasone diproprionate.  Pediatrics. 2000 a;  105 E23
    CrossrefPubMedGoogle Scholar
  • 79 Skoner D P, Szefler S J, Welch M, Walton-Bowen K, Cruz-Rivera M, Smith J A. Longitudinal growth in infants and young children treated with budesonide inhalation suspension for persistent asthma.  J Allergy Clin Immunol. 2000 b;  105 259-268
    CrossrefPubMedGoogle Scholar
  • 80 Simard J, Labrie F. Characteristics of the desensitisation of growth hormone and cyclic AMP responses to growth hormone-releasing factor and prostaglandin E2 in rat anterior pituitary cells in culture.  Mol Cell Endocrinol. 1986;  48 79-89
    PubMedGoogle Scholar
  • 81 Smith J M. Prolonged treatment with prednisolone in children with asthma.  Tubercle. 1963;  44 281-284
    PubMedGoogle Scholar
  • 82 Smith T F, Hudgel D W. Arterial oxygen desaturation during sleep in children with asthma and its relation to airway obstruction and ventilatory drive.  Pediatrics. 1980;  66 746-751
    PubMedGoogle Scholar
  • 83 Snyder R D, Collipp P J, Greene J S. Growth and ultimate height of children with asthma.  Clin Pediatr. 1967;  6 389-392
    PubMedGoogle Scholar
  • 84 Sorva R A, Turpeinen M T. Asthma, glucocorticoids and growth.  Ann Med. 1994;  26 309-314
    PubMedGoogle Scholar
  • 85 Spock A. Growth patterns in 200 children with bronchial asthma.  Ann Allergy. 1965;  23 608-615
    PubMedGoogle Scholar
  • 86 Styne D M. The testes: disorders of sexual differentiation and puberty. In: Sperling MA (ed). Pediatric Endocrinology WB Staunders Company Philadelphia 1996: 423-476
    Google Scholar
  • 87 Szentivanyi A. The beta adrenergic theory of the atopic abnormality in bronchial asthma.  J Allergy Clin Immunol. 1968;  42 203-232
    PubMedGoogle Scholar
  • 88 Vimpani G V, Vimpani A F, Farquhar J W. Growth retardation in chronic asthma.  Lancet. 1976;  9 422
    PubMedGoogle Scholar
  • 89 Welch R D, Johnston C E, Waldron M J, Poteet B. Intraosseous infusion of prostaglandin E2 in the caprine tibia.  J Orthop Res. 1993;  11 110-121
    CrossrefPubMedGoogle Scholar
  • 90 Welsh J B. The effect of allergy management on growth and development of allergic children.  J Pediatr. 1951;  38 571-575
    PubMedGoogle Scholar
  • 91 Wiersbitzky S, Ballke E H, Patzschke V, Patzschke M, Kruse E, Hein J, Kiauleikene M. Das somatische Gedeihen von Kindern mit Asthma bronchiale unter verschiedenen Therapie-Regimen.  Ärztl Jugendkd. 1982;  73 225-232
    PubMedGoogle Scholar
  • 92 Wittig H J, McLaughlin E D, Belloit J D. Growth retardation in children with chronic asthma in the absence of prolonged steroid therapy.  Allergol Immunpathol. 1978;  6 203-208
    PubMedGoogle Scholar
  • 93 Wolthers O D. Long-, intermediate- and short-term growth studies in asthmatics children treated with inhaled glucocorticosteroids.  Eur Resp J. 1996;  9 821-827
    PubMedGoogle Scholar
  • 94 Wolthers O D, Heuck C, Ternowitz T, Heickendorff L, Nielsen H K, Frystyk J. Insulin-like growth factor axis, bone and collagen turnover in children with atopic dermatitis treated with topical glucocorticosteroids.  Dermatology. 1996;  192 337-342
    PubMedGoogle Scholar
  • 95 Wolthers O D, Pedersen S. Short-term growth in children with allergic rhinitis treated with oral antihistamine, depot and intranasal glucocorticosteroids.  A Paediatr. 1993;  82 635-640
    PubMedGoogle Scholar
  • 96 Wolthers O D, Pedersen S. Short term linear growth in asthmatic children during treatment with prednisolone.  Br Med J. 1990;  301 145-148
    PubMedGoogle Scholar
  • 97 Yang R S, Liu T K, Lin-Shiau S Y. Increased bone growth by local prostaglandin E2 in rats.  Calcif Tissue Int. 1993;  52 57-61
    CrossrefPubMedGoogle Scholar
  • 98 Zeitlin S R, Bond S, Wootton S, Gregson R K, Radford M. Increased resting energy expenditure in childhood asthma: does this contribute toward growth failure?.  Arch Dis Child. 1992;  67 1366-1369
    PubMedGoogle Scholar

PD Dr. med. Walter F. Baum

Department of Paediatrics

Martin-Luther-University Halle-Wittenberg

Ernst-Grube-Str. 40

D-06097 Halle/Saale

Germany

Email: walter.baum@medizin.uni-halle.de