J Pediatr Intensive Care
DOI: 10.1055/s-0044-1788918
Original Article

Emergency Endotracheal Intubations at a Pediatric Intensive Care Unit—Incidence and Hemodynamic Complications

1   Dеpartment of Pediatric Cardiology, Pulmonology and Pediatric Intеnsive Care Medicine, University Children's Hospital Tübingen, Tübingen, Germany
,
Felix Neunhoeffer
1   Dеpartment of Pediatric Cardiology, Pulmonology and Pediatric Intеnsive Care Medicine, University Children's Hospital Tübingen, Tübingen, Germany
,
Matthias Kumpf
1   Dеpartment of Pediatric Cardiology, Pulmonology and Pediatric Intеnsive Care Medicine, University Children's Hospital Tübingen, Tübingen, Germany
,
Michael Hofbeck
1   Dеpartment of Pediatric Cardiology, Pulmonology and Pediatric Intеnsive Care Medicine, University Children's Hospital Tübingen, Tübingen, Germany
,
Danial Saeed
1   Dеpartment of Pediatric Cardiology, Pulmonology and Pediatric Intеnsive Care Medicine, University Children's Hospital Tübingen, Tübingen, Germany
,
Jörg Michel
1   Dеpartment of Pediatric Cardiology, Pulmonology and Pediatric Intеnsive Care Medicine, University Children's Hospital Tübingen, Tübingen, Germany
,
Maximilian Gross
1   Dеpartment of Pediatric Cardiology, Pulmonology and Pediatric Intеnsive Care Medicine, University Children's Hospital Tübingen, Tübingen, Germany
› Author Affiliations
Funding None.

Abstract

Emergency tracheal intubation (TI) in a critically ill child is a life-saving, high-risk procedure often associated with adverse events and complications. Efforts have been undertaken to increase the safety of TIs. Integrated checklists, simulation-based training, and video laryngoscope-assisted intubations have proven effective. The study's primary aim was to evaluate the frequency of emergency TIs at a pediatric intensive care unit (PICU) and to examine the incidence of peri-intubation hemodynamic complications. We conducted a single-center, retrospective analysis of unplanned (nonelective and emergency) intubations in a multidisciplinary PICU. Patients between 0 and 18 years admitted from January 2020 until December 2022 were included in the analysis. There was a total of 144 emergency TIs. In 92.6% of the cases, an underlying chronic disease existed. The most common indication for emergency TI was respiratory failure (61.0%). Adverse intubation-associated hemodynamic events were found in 18 (12.5%), cardiac arrest in 6 (4.2%), and emergency TI under ongoing cardiopulmonary resuscitation (CPR) in 12 (8.3%) cases. Twenty-two (15.3%) children died during the PICU stay after emergency TI due to the underlying condition. In the group of children showing adverse hemodynamic effects after TI, fewer children were on noninvasive respiratory support (50 vs. 75.2%, p = 0.007) and received catecholamine therapy more frequently before complicated emergency TI than those without complicated emergency TI (62.5 vs. 38.0%, p = 0.039). Children in the latter group had both a longer duration of mechanical ventilation (11 vs. 7 days, p = 0.045) and a longer PICU stay (18 vs. 12 days, p = 0.042) compared with the group of complicated emergency TIs. Most emergency TIs (59.0%) occurred off-hours, between 7 p.m. and 7 a.m., or on weekends. Emergency TIs occur unexpectedly, often outside regular operating hours, and are associated with a higher mortality and morbidity rate. Using noninvasive respiratory support could potentially reduce adverse intubation-associated hemodynamic events in emergency TI.



Publication History

Received: 08 December 2023

Accepted: 18 July 2024

Article published online:
06 September 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Stuttgart · New York

 
  • References

  • 1 Atkins DL, Berger S, Duff JP. et al. Part 11: Pediatric Basic Life Support and Cardiopulmonary Resuscitation Quality: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care (Reprint). Pediatrics 2015; 136 (Suppl. 02) S167-S175
  • 2 Bano S, Akhtar S, Zia N, Khan UR, Haq AU. Pediatric endotracheal intubations for airway management in the emergency department. Pediatr Emerg Care 2012; 28 (11) 1129-1131
  • 3 Easley RB, Segeleon JE, Haun SE, Tobias JD. Prospective study of airway management of children requiring endotracheal intubation before admission to a pediatric intensive care unit. Crit Care Med 2000; 28 (06) 2058-2063
  • 4 Long E, Sabato S, Babl FE. Endotracheal intubation in the pediatric emergency department. Paediatr Anaesth 2014; 24 (12) 1204-1211
  • 5 Bowles TM, Freshwater-Turner DA, Janssen DJ, Peden CJ. RTIC Severn Group. Out-of-theatre tracheal intubation: prospective multicentre study of clinical practice and adverse events. Br J Anaesth 2011; 107 (05) 687-692
  • 6 Long E, Barrett MJ, Peters C, Sabato S, Lockie F. Emergency intubation of children outside of the operating room. Paediatr Anaesth 2020; 30 (03) 319-330
  • 7 Hagiwara Y, Goto T, Ohnishi S. et al; Japanese Emergency Medicine Network Investigators. Airway management in the pediatric emergency department in Japan: a multicenter prospective observational study. Acute Med Surg 2022; 9 (01) e798
  • 8 Parker MM, Nuthall G, Brown III C. et al; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Relationship between adverse tracheal intubation associated events and PICU outcomes. Pediatr Crit Care Med 2017; 18 (04) 310-318
  • 9 Nishisaki A, Turner DA, Brown III CA, Walls RM, Nadkarni VM. National Emergency Airway Registry for Children (NEAR4KIDS), Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. A National Emergency Airway Registry for children: landscape of tracheal intubation in 15 PICUs. Crit Care Med 2013; 41 (03) 874-885
  • 10 Rehder KJ, Giuliano Jr JS, Napolitano N. et al; National Emergency Airway Registry for Children and Pediatric Acute Lung Injury and Sepsis Investigators. Increased occurrence of tracheal intubation-associated events during nights and weekends in the PICU. Crit Care Med 2015; 43 (12) 2668-2674
  • 11 Löllgen RMC, Pontin J, Gow M, McCaskill ME. Adverse events and risk factors during emergency intubation in a tertiary paediatric emergency department. Eur J Emerg Med 2018; 25 (03) 209-215
  • 12 Li S, Rehder KJ, Giuliano Jr JS. et al; National Emergency Airway Registry for Children (NEAR4KIDS) Investigators, Pediatric Acute Lung Injury and Sepsis Investigator PALISI Network Investigators. Development of a quality improvement bundle to reduce tracheal intubation-associated events in pediatric ICUs. Am J Med Qual 2016; 31 (01) 47-55
  • 13 Liao CC, Liu FC, Li AH, Yu HP. Video laryngoscopy-assisted tracheal intubation in airway management. Expert Rev Med Devices 2018; 15 (04) 265-275
  • 14 Schmucker Agudelo E, Farré Pinilla M, Andreu Riobello E. et al. An update in paediatric airway management. Rev Esp Anestesiol Reanim (Engl Ed) 2022; 69 (08) 472-486
  • 15 Koponen T, Karttunen J, Musialowicz T, Pietiläinen L, Uusaro A, Lahtinen P. Vasoactive-inotropic score and the prediction of morbidity and mortality after cardiac surgery. Br J Anaesth 2019; 122 (04) 428-436
  • 16 Carroll CL, Spinella PC, Corsi JM, Stoltz P, Zucker AR. Emergent endotracheal intubations in children: be careful if it's late when you intubate. Pediatr Crit Care Med 2010; 11 (03) 343-348
  • 17 Pokrajac N, Sbiroli E, Hollenbach KA, Kohn MA, Contreras E, Murray M. Risk factors for peri-intubation cardiac arrest in a pediatric emergency department. Pediatr Emerg Care 2022; 38 (01) e126-e131
  • 18 Green RS, Turgeon AF, McIntyre LA. et al; Canadian Critical Care Trials Group (CCCTG). Postintubation hypotension in intensive care unit patients: a multicenter cohort study. J Crit Care 2015; 30 (05) 1055-1060
  • 19 Emeriaud G, Napolitano N, Polikoff L. et al; National Emergency Airway Registry for Children (NEAR4KIDS) Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI). Impact of failure of noninvasive ventilation on the safety of pediatric tracheal intubation. Crit Care Med 2020; 48 (10) 1503-1512
  • 20 Crulli B, Loron G, Nishisaki A, Harrington K, Essouri S, Emeriaud G. Safety of paediatric tracheal intubation after non-invasive ventilation failure. Pediatr Pulmonol 2016; 51 (02) 165-172
  • 21 Hodgson KA, Owen LS, Manley BJ. Nasal high-flow therapy during neonatal endotracheal intubation. Reply. N Engl J Med 2022; 387 (04) 382
  • 22 Mittiga MR, Geis GL, Kerrey BT, Rinderknecht AS. The spectrum and frequency of critical procedures performed in a pediatric emergency department: implications of a provider-level view. Ann Emerg Med 2013; 61 (03) 263-270
  • 23 Van Oeveren L, Donner J, Fantegrossi A, Mohr NM, Brown III CA. Telemedicine-assisted intubation in rural emergency departments: a national emergency airway registry study. Telemed J E Health 2017; 23 (04) 290-297