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DOI: 10.1055/s-0043-1778661
Microenvironment of the Lower Reproductive Tract: Focus on the Cervical Mucus Plug
Funding This study is supported by the Spanish Ministry of Economy, Industry and Competitiveness (MINECO) and European Regional Development Fund (FEDER) by MCIN/AEI/10.13039/501100011033 and ERFP “A way of making Europe” projects Endo-Map PID2021-127280OB-I00 and ROSY CNS2022-135999; and the Margarita Salas program for the Requalification of the Spanish University system (UJAR01MS).![](https://www.thieme-connect.de/media/srm/202305/lookinside/thumbnails/10-1055-s-0043-1778661_2300028-1.jpg)
Abstract
The female lower reproductive tract microbiota is a complex ecosystem comprising various microorganisms that play a pivotal role in maintaining women's reproductive well-being. During pregnancy, the vaginal microbiota undergoes dynamic changes that are important for a successful gestation. This review summarizes the implications of the cervical mucus plug microenvironment and its profound impact on reproductive health. Further, the symbiotic relationship between the vaginal microbiome and the cervical mucus plug is highlighted, with a special emphasis on how this natural barrier serves as a guardian against ascending infections. Understanding this complex host–microbes interplay could pave the way for innovative approaches to improve women's reproductive health and fertility.
Publication History
Article published online:
23 January 2024
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