Facial Plast Surg 2018; 34(06): 597-604
DOI: 10.1055/s-0038-1676076
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Free Flap Head and Neck Reconstruction with an Emphasis on Postoperative Care

Daniel Richard van Gijn
1   Department of Oral and Maxillofacial Surgery, Royal Surrey County Hospital NHS Foundation Trust, Guildford, Surrey, United Kingdom
,
Jacob D'Souza
1   Department of Oral and Maxillofacial Surgery, Royal Surrey County Hospital NHS Foundation Trust, Guildford, Surrey, United Kingdom
,
Wendy King
1   Department of Oral and Maxillofacial Surgery, Royal Surrey County Hospital NHS Foundation Trust, Guildford, Surrey, United Kingdom
,
Michael Bater
1   Department of Oral and Maxillofacial Surgery, Royal Surrey County Hospital NHS Foundation Trust, Guildford, Surrey, United Kingdom
› Author Affiliations
Further Information

Publication History

Publication Date:
28 December 2018 (online)

Abstract

Microsurgical free tissue transfer represents the mainstay of care in both ablative locoregional management and the simultaneous reconstruction of a defect. Advances in microsurgical techniques have helped balance the restoration of both form and function—decreasing the significant morbidity once associated with large ablative, traumatic, or congenital defects—while providing immediate reconstruction enabling early aesthetic and functional rehabilitation. There are a multitude of perioperative measures and considerations that aim to maximize the success of free tissue transfer. These include nutritional support, tight glycemic control, acknowledgment of psychological and psychiatric factors, intraoperative surgical technique, and close postoperative monitoring of the patients' hemodynamic physiology. While the success rates of free tissue transfer in experienced hands are comparable to alternative options, the consequences of flap failure are catastrophic—with the potential for significant patient morbidity, prolonged hospital stay (and associated increased financial implications), and increasingly limited options for further reconstruction. Success is entirely dependent on a continuous arterial inflow and venous outflow until neovascularization occurs. Flap failure is multifactorial and represents a dynamic process from the potentially reversible failing flap to the necrotic irreversibly failed flap—necessitating debridement, prolonged wound care, and ultimately decisions concerned with future reconstruction. The overriding goal of free flap monitoring is therefore the detection of microvascular complications prior to permanent injury occurring—identifying and intervening within that critical period between the failing flap and the failed flap—maximizing the potential for salvage. With continued technique refinement, microvascular free flap reconstruction offers patients the chance for both reliable functional and aesthetic restoration in the face of significant ablative defects. The caveat to this optimism is the requirement for considered perioperative care and the optimization of those factors that may offer the difference between success and failure.

Note

The authors of this article practice in a U.K. regional center for the management of head and neck cancer. They have extensive experience in the treatment of patients with free tissue transfer, and an interest in reducing complications and improving outcomes for this patient group.


 
  • References

  • 1 Taylor GI, Miller GD, Ham FJ. The free vascularized bone graft. A clinical extension of microvascular techniques. Plast Reconstr Surg 1975; 55 (05) 533-544
  • 2 Hidalgo DA. Fibula free flap: a new method of mandible reconstruction. Plast Reconstr Surg 1989; 84 (01) 71-79
  • 3 Lutz BS, Wei F-C. Microsurgical workhorse flaps in head and neck reconstruction. Clin Plast Surg 2005; 32 (03) 421-430 , vii
  • 4 Bater M, King W, Teare J, D'Souza J. Enhanced recovery in patients having free tissue transfer for head and neck cancer: does it make a difference?. Br J Oral Maxillofac Surg 2017; 55 (10) 1024-1029
  • 5 Findlay G, Goodwin A, Protopapa K, Smith N, Mason M. Knowing the Risk: A review of the perioperative care of surgical patients. London, UK: National Confidential Enquiry into Patient Outcome and Death; 2011
  • 6 Stavrianos SD, McLean NR, Fellows S. , et al. Microvascular histopathology in head and neck oncology. Br J Plast Surg 2003; 56 (02) 140-144
  • 7 Howard MA, Cordeiro PG, Disa J. , et al. Free tissue transfer in the elderly: incidence of perioperative complications following microsurgical reconstruction of 197 septuagenarians and octogenarians. Plast Reconstr Surg 2005; 116 (06) 1659-1668 , discussion 1669–1671
  • 8 Serletti JM, Higgins JP, Moran S, Orlando GS. Factors affecting outcome in free-tissue transfer in the elderly. Plast Reconstr Surg 2000; 106 (01) 66-70
  • 9 Tew GA, Ayyash R, Durrand J, Danjoux GR. Clinical guideline and recommendations on pre-operative exercise training in patients awaiting major non-cardiac surgery. Anaesthesia 2018; 73 (06) 750-768
  • 10 Cheng N-C, Ko J-Y, Tai H-C, Horng SY, Tang YB. Microvascular head and neck reconstruction in patients with liver cirrhosis. Head Neck 2008; 30 (07) 829-835
  • 11 Guo S, Dipietro LAJ. Factors affecting wound healing. J Dent Res 2010; 89 (03) 219-229
  • 12 Padubidri AN, Yetman R, Browne E. , et al. Complications of postmastectomy breast reconstructions in smokers, ex-smokers, and nonsmokers. Plast Reconstr Surg 2001; 107 (02) 342-349 , discussion 350–351
  • 13 Mehrara BJ, Santoro TD, Arcilla E, Watson JP, Shaw WW, Da Lio AL. Complications after microvascular breast reconstruction: experience with 1195 flaps. Plast Reconstr Surg 2006; 118 (05) 1100-1109 , discussion 1110–1111
  • 14 Correia MI, Waitzberg DL. The impact of malnutrition on morbidity, mortality, length of hospital stay and costs evaluated through a multivariate model analysis. Clin Nutr 2003; 22 (03) 235-239
  • 15 Nutrition support for adults: oral nutrition support, enteral tube feeding and parenteral nutrition. Clinical guideline. Published: February 22, 2006. Available at: nice.org.uk/guidance/cg32 . Accessed November 2, 2018
  • 16 Miller RB, Reece G, Kroll SS. , et al. Microvascular breast reconstruction in the diabetic patient. Plast Reconstr Surg 2007; 119 (01) 38-45 , discussion 46–48
  • 17 Poldermans D, Bax JJ, Boersma E. , et al; Task Force for Preoperative Cardiac Risk Assessment and Perioperative Cardiac Management in Non-cardiac Surgery of European Society of Cardiology (ESC); European Society of Anaesthesiology (ESA). Guidelines for pre-operative cardiac risk assessment and perioperative cardiac management in non-cardiac surgery: the Task Force for Preoperative Cardiac Risk Assessment and Perioperative Cardiac Management in Non-cardiac Surgery of the European Society of Cardiology (ESC) and endorsed by the European Society of Anaesthesiology (ESA). Eur J Anaesthesiol 2010; 27 (02) 92-137
  • 18 Archer J, Hutchison I, Korszun A. Mood and malignancy: head and neck cancer and depression. J Oral Pathol Med 2008; 37 (05) 255-270
  • 19 DiMatteo MR, Lepper HS, Croghan TW. Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence. Arch Intern Med 2000; 160 (14) 2101-2107
  • 20 Rodby KA, Turin S, Jacobs RJ. , et al. Advances in oncologic head and neck reconstruction: systematic review and future considerations of virtual surgical planning and computer aided design/computer aided modeling. J Plast Reconstr Aesthet Surg 2014; 67 (09) 1171-1185
  • 21 Tan NC, Lin PY, Chiang YC. , et al. Influence of neck dissection and preoperative irradiation on microvascular head and neck reconstruction-analysis of 853 cases. Microsurgery 2014; 34 (08) 602-607
  • 22 Takamatsu A, Harashina T, Inoue T. Selection of appropriate recipient vessels in difficult, microsurgical head and neck reconstruction. J Reconstr Microsurg 1996; 12 (08) 499-507 , discussion 508–513
  • 23 Hanasono MM, Corbitt CA, Yu P, Skoracki RJ. Success of sequential free flaps in head and neck reconstruction. J Plast Reconstr Aesthet Surg 2014; 67 (09) 1186-1193
  • 24 Swanson EW, Cheng HT, Susarla SM. , et al. Intraoperative use of vasopressors is safe in head and neck free tissue transfer. J Reconstr Microsurg 2016; 32 (02) 87-93
  • 25 Kelly DA, Reynolds M, Crantford C, Pestana IA. Impact of intraoperative vasopressor use in free tissue transfer for head, neck, and extremity reconstruction. Ann Plast Surg 2014; 72 (06) S135-S138
  • 26 Eley KA, Young JD, Watt-Smith SR. Epinephrine, norepinephrine, dobutamine, and dopexamine effects on free flap skin blood flow. Plast Reconstr Surg 2012; 130 (03) 564-570
  • 27 Scholz A, Pugh S, Fardy M, Shafik M, Hall JE. The effect of dobutamine on blood flow of free tissue transfer flaps during head and neck reconstructive surgery. Anaesthesia 2009; 64 (10) 1089-1093
  • 28 Yokoyama T, Tosa Y, Kadomatsu K, Sato K, Hosaka Y. A novel approach for preventing the development of persistent vasospasms after microsurgery for the extremities: intermittent topical lidocaine application. J Reconstr Microsurg 2010; 26 (02) 79-85
  • 29 Weinzweig N, Lukash F, Weinzweig J. Topical and systemic calcium channel blockers in the prevention and treatment of microvascular spasm in a rat epigastric island skin flap model. Ann Plast Surg 1999; 42 (03) 320-326
  • 30 Hanasono MM, Barnea Y, Skoracki RJ. Microvascular surgery in the previously operated and irradiated neck. Microsurgery 2009; 29 (01) 1-7
  • 31 Cameron M, Corner A, Diba A, Hankins M. Development of a tracheostomy scoring system to guide airway management after major head and neck surgery. Int J Oral Maxillofac Surg 2009; 38 (08) 846-849
  • 32 Marsh M, Elliott S, Anand R, Brennan PA. Early postoperative care for free flap head & neck reconstructive surgery--a national survey of practice. Br J Oral Maxillofac Surg 2009; 47 (03) 182-185
  • 33 Quinlan J. Anaesthesia for reconstructive surgery. Anaesth Intensive Care Med 2006; 7 (01) 31-33
  • 34 Szakmany T, Dodd M, Dempsey GA. , et al. The influence of allogenic blood transfusion in patients having free-flap primary surgery for oral and oropharyngeal squamous cell carcinoma. Br J Cancer 2006; 94 (05) 647-653
  • 35 Chen CM, Ashjian P, Disa JJ, Cordeiro PG, Pusic AL, Mehrara BJ. Is the use of intraoperative heparin safe?. Plast Reconstr Surg 2008; 121 (03) 49e-53e
  • 36 Ashjian P, Chen CM, Pusic A, Disa JJ, Cordeiro PG, Mehrara BJ. The effect of postoperative anticoagulation on microvascular thrombosis. Ann Plast Surg 2007; 59 (01) 36-39 , discussion 39–40
  • 37 Bui DT, Cordeiro PG, Hu QY, Disa JJ, Pusic A, Mehrara BJ. Free flap reexploration: indications, treatment, and outcomes in 1193 free flaps. Plast Reconstr Surg 2007; 119 (07) 2092-2100
  • 38 Al-Dam A, Zrnc TA, Hanken H. , et al. Outcome of microvascular free flaps in a high-volume training centre. J Craniomaxillofac Surg 2014; 42 (07) 1178-1183
  • 39 Yang Q, Ren ZH, Chickooree D. , et al. The effect of early detection of anterolateral thigh free flap crisis on the salvage success rate, based on 10 years of experience and 1072 flaps. Int J Oral Maxillofac Surg 2014; 43 (09) 1059-1063
  • 40 Disa JJ, Cordeiro PG, Hidalgo DA. Efficacy of conventional monitoring techniques in free tissue transfer: an 11-year experience in 750 consecutive cases. Plast Reconstr Surg 1999; 104 (01) 97-101
  • 41 Geis S, Prantl L, Dolderer J, Lamby P, Mueller S, Jung EM. Postoperative monitoring of local and free flaps with contrast-enhanced ultrasound (CEUS)--analysis of 112 patients. Ultraschall Med 2013; 34 (06) 550-558
  • 42 Swartz WM, Izquierdo R, Miller MJ. Implantable venous Doppler microvascular monitoring: laboratory investigation and clinical results. Plast Reconstr Surg 1994; 93 (01) 152-163
  • 43 Rozen WM, Chubb D, Whitaker IS, Acosta R. The efficacy of postoperative monitoring: a single surgeon comparison of clinical monitoring and the implantable Doppler probe in 547 consecutive free flaps. Microsurgery 2010; 30 (02) 105-110
  • 44 Schmulder A, Gur E, Zaretski A. Eight-year experience of the Cook-Swartz Doppler in free-flap operations: microsurgical and reexploration results with regard to a wide spectrum of surgeries. Microsurgery 2011; 31 (01) 1-6
  • 45 Udesen A, Løntoft E, Kristensen SR. Monitoring of free TRAM flaps with microdialysis. J Reconstr Microsurg 2000; 16 (02) 101-106
  • 46 Whitaker IS, Rozen WM, Chubb D. , et al. Postoperative monitoring of free flaps in autologous breast reconstruction: a multicenter comparison of 398 flaps using clinical monitoring, microdialysis, and the implantable Doppler probe. J Reconstr Microsurg 2010; 26 (06) 409-416
  • 47 Whitney TM, Lineaweaver WC, Billys JB. , et al. Improved salvage of complicated microvascular transplants monitored with quantitative fluorometry. Plast Reconstr Surg 1992; 90 (01) 105-111
  • 48 Wong CH, Wei FC. Microsurgical free flap in head and neck reconstruction. Head Neck 2010; 32 (09) 1236-1245
  • 49 Chen K-T, Mardini S, Chuang DC-C. , et al. Timing of presentation of the first signs of vascular compromise dictates the salvage outcome of free flap transfers. Plast Reconstr Surg 2007; 120 (01) 187-195