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J Pediatr Infect Dis 2006; 01(04): 195-203
DOI: 10.1055/s-0035-1557097
Review Article
Georg Thieme Verlag KG Stuttgart – New York

Toll-like receptors; integrate innate and adaptive immunity, promise innovative therapies

Alişan Yildiran
a   Department of Pediatrics, Division of Allergy and Immunology, Faculty of Medicine, Ankara University, Ankara, Turkiye
,
Aydan İkincioǧullari
a   Department of Pediatrics, Division of Allergy and Immunology, Faculty of Medicine, Ankara University, Ankara, Turkiye
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Publication History

21 August 2006

29 September 2006

Publication Date:
28 July 2015 (online)

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Abstract

Innate component of immunity is a skilful system that senses invading microbial pathogens and integrates to adaptive immunity by Toll-like receptors (TLRs). Another function of TLRs is to work in sterile inflammation to ligands derived from damaged cells, which are not usually present in the extracellular environment. Thus, TLRs have very important interferences in the pathogenesis of inflammatory and immune diseases. The discovery of TLRs has transformed our approach to immunology and related diseases.

Keywords

Innate immunity - Toll-like receptors - NLR