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Klin Monbl Augenheilkd 2014; 231(4): 453-454
DOI: 10.1055/s-0034-1368285
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Georg Thieme Verlag KG Stuttgart · New York

Small-Cell Lung Carcinoma Presenting as Paraneoplastic Autoimmune Optic Neuritis with Retinitis

Kleinzelliges Lungenkarzinom präsentiert sich als paraneoplastische autoimmune optische Neuritis mit Retinitis
O. Passarin
1   Jules-Gonin Eye Hospital, University of Lausanne, Lausanne, Switzerland (Chairman: Prof F. Behar-Cohen)
,
S. Reymond
2   Department of Neurology, Hôpital du Valais Sion, Switzerland (Chairman: Prof J. A. Ghika)
,
A. Michel
3   Ophtalmologue FMH, Avenue du Rothorn 11, 3960 Sierre, Switzerland
,
J.-A. Ghika
2   Department of Neurology, Hôpital du Valais Sion, Switzerland (Chairman: Prof J. A. Ghika)
,
Y. Guex-Crosier
1   Jules-Gonin Eye Hospital, University of Lausanne, Lausanne, Switzerland (Chairman: Prof F. Behar-Cohen)
› Author Affiliations
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Publication History

Publication Date:
25 April 2014 (online)

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Background

Optic neuritis associated with retinitis and severe vitreous inflammation is a challenging diagnostic problem. Clinical findings appear similar or identical in various inflammatory conditions such as ischemic neuropathy, large B cell lymphoma, demyelinating disease, severe uveitis, or paraneoplastic disorders [1].

Paraneoplastic optic neuritis is an ocular manifestation of systemic neoplasia that is clinically characterized by subacute vision reduction, optic discs swelling and neurological symptoms. In this contest, two auto-antibodies have been described in order to define two of the most important paraneoplastic syndromes which involve the eye: CAR-IgG directed against recoverin (“carcinoma-associated retinopathy”) and CRMP-5-IgG (“collapsin response-mediator protein 5”) [2]. The latter defines a paraneoplastic ophthalmological entity combining optic neuritis, retinitis and vitreous inflammatory cells.

 

  • References

  • 1 Ray S, Gragoudas E. Neuroretinitis. Int Ophthalmol Clin 2001; 41: 83-102
    CrossrefPubMedGoogle Scholar
  • 2 Cross SA, Salomao DR, Parisi JE et al. Paraneoplastic autoimmune optic neuritis with retinitis defined by CRMP-5-IgG. Ann Neurol 2003; 54: 38-50
    CrossrefPubMedGoogle Scholar
  • 3 Damek DM. Paraneoplastic retinopathy/optic neuropathy. Curr Treat Options Neurol 2005; 7: 57-67
    CrossrefPubMedGoogle Scholar
  • 4 Shiraga S, Adamus G. Mechanism of CAR syndrome: anti-recoverin antibodies are the inducers of retinal cell apoptotic death via the caspase 9- and caspase 3-dependent pathway. J Neuroimmunol 2002; 132: 72-82
    CrossrefPubMedGoogle Scholar
  • 5 Murphy MA, Thirkill CE, Hart jr. WM. Paraneoplastic retinopathy: a novel autoantibody reaction associated with small-cell lung carcinoma. J Neuroophthalmol 1997; 17: 77-83
    PubMedGoogle Scholar