J Reconstr Microsurg 2011; 27(4): 243-250
DOI: 10.1055/s-0031-1275488
© Thieme Medical Publishers

Successful Salvage of Venous Thrombosis of a Free Flap by Creation of a Venocutaneous Fistula

Neil F. Jones1 , 3 , 4 , Michael P. Lin2 , Brian P. Dickinson3 , Jeffrey Eckardt4
  • 1Department of Orthopaedic Surgery, Division of Hand Surgery, University of California, Irvine, Orange
  • 2Aesthetic and Plastic Surgery Institute, University of California, Irvine, Orange
  • 3Division of Plastic and Reconstructive Surgery, University of California, Los Angeles, California
  • 4Department of Orthopedic Surgery, University of California, Los Angeles, California
Further Information

Publication History

Publication Date:
24 March 2011 (online)

ABSTRACT

This report describes the creation of a venocutaneous fistula to salvage a free fibular osteocutaneous flap compromised by extensive venous thrombosis. This technique has previously been described for salvage of digital replants, but this is the first report of a venocutaneous fistula being used to salvage a free flap. A 21-year-old woman underwent a 9-cm resection of the distal left tibia for an aneurysmal bone cyst. A contralateral right fibular osteocutaneous free flap was used for reconstruction. On postoperative day 2, the skin paddle showed evidence of venous congestion. Reexploration demonstrated extensive thrombosis throughout the entire venous system of the flap. The venae comitantes were transected as far back as possible and brought to the surface of the skin through two small stab wounds to allow venous egress. After a short course of heparin and dextran, the skin flap healed uneventfully and both osteosynthesis sites consolidated. A venocutaneous fistula provides a path of relatively low resistance for venous outflow, improving the arterial inflow–venous outflow balance for a short time until neovascularization and collateral venous channels develop. The venocutaneous fistula technique may be considered for salvage of free flaps compromised by extensive venous thrombosis.

REFERENCES

  • 1 Kroll S S, Schusterman M A, Reece G P et al.. Choice of flap and incidence of free flap success.  Plast Reconstr Surg. 1996;  98 459-463
  • 2 Aydin M A, Mavili M E. Examining microcirculation improves the angiosome theory in explaining the delay phenomenon in a rabbit model.  J Reconstr Microsurg. 2003;  19 187-194
  • 3 Fahmy H W, Moneim M S. The effect of prolonged blood stasis on a microarterial repair.  J Reconstr Microsurg. 1988;  4 139-143
  • 4 Fernandez E J, Nadal R D, Gonzalez S M, Caffee H H. The effect of stasis on a microvascular anastomosis.  Microsurgery. 1983;  4 176-177
  • 5 Hauge E M, Balling E, Hartmund T, Hjortdal V E. Secondary ischemia caused by venous or arterial occlusion shows differential effects on myocutaneous island flap survival and muscle ATP levels.  Plast Reconstr Surg. 1997;  99 825-833
  • 6 Machens H-G, Mailänder P, Pasel J et al.. Flap perfusion after free musculocutaneous tissue transfer: the impact of postoperative complications.  Plast Reconstr Surg. 2000;  105 2395-2399
  • 7 Davis R E, Wachholz J H, Jassir D, Perlyn C A, Agrama M H. Comparison of topical anti-ischemic agents in the salvage of failing random-pattern skin flaps in rats.  Arch Facial Plast Surg. 1999;  1 27-32
  • 8 Dabb R W, Malone J M, Leverett L C. The use of medicinal leeches in the salvage of flaps with venous congestion.  Ann Plast Surg. 1992;  29 250-256
  • 9 de Chalain T M. Exploring the use of the medicinal leech: a clinical risk-benefit analysis.  J Reconstr Microsurg. 1996;  12 165-172
  • 10 Peter F W, Franken R J, Wang W Z et al.. Effect of low dose aspirin on thrombus formation at arterial and venous microanastomoses and on the tissue microcirculation.  Plast Reconstr Surg. 1997;  99 1112-1121
  • 11 Cooley B C, Gould J S. Experimental models for evaluating antithrombotic therapies in replantation microsurgery.  Microsurgery. 1987;  8 230-233
  • 12 Chung T L, Pumplin D W, Holton III L H, Taylor J A, Rodriguez E D, Silverman R P. Prevention of microsurgical anastomotic thrombosis using aspirin, heparin, and the glycoprotein IIb/IIIa inhibitor tirofiban.  Plast Reconstr Surg. 2007;  120 1281-1288
  • 13 Hupkens P, Cooley B C. Comparison of arterial and venous patency in a rat model of subendothelium-stimulated thrombosis.  Microsurgery. 1996;  17 226-229
  • 14 Ritter E F, Cronan J C, Rudner A M, Serafin D, Klitzman B. Improved microsurgical anastomotic patency with low molecular weight heparin.  J Reconstr Microsurg. 1998;  14 331-336
  • 15 Jallali N. Dextrans in microsurgery: a review.  Microsurgery. 2003;  23 78-80
  • 16 Panchapakesan V, Addison P, Beausang E, Lipa J E, Gilbert R W, Neligan P C. Role of thrombolysis in free-flap salvage.  J Reconstr Microsurg. 2003;  19 523-530
  • 17 Casey III W J, Craft R O, Rebecca A M, Smith A A, Yoon S. Intra-arterial tissue plasminogen activator: an effective adjunct following microsurgical venous thrombosis.  Ann Plast Surg. 2007;  59 520-525
  • 18 Serletti J M, Moran S L, Orlando G S, O'Connor T, Herrera H R. Urokinase protocol for free-flap salvage following prolonged venous thrombosis.  Plast Reconstr Surg. 1998;  102 1947-1953
  • 19 Rinker B D, Stewart D H, Pu L L, Vasconez H C. Role of recombinant tissue plasminogen activator in free flap salvage.  J Reconstr Microsurg. 2007;  23 69-73
  • 20 Khouri R K, Cooley B C, Kunselman A R et al.. A prospective study of microvascular free-flap surgery and outcome.  Plast Reconstr Surg. 1998;  102 711-721
  • 21 Miller M J, Schusterman M A, Reece G P, Kroll S S. Interposition vein grafting in head and neck reconstructive microsurgery.  J Reconstr Microsurg. 1993;  9 245-251 discussion 251-252
  • 22 Kamei K, Sinokawa Y, Kishibe M. The venocutaneous fistula: a new technique for reducing venous congestion in replanted fingertips.  Plast Reconstr Surg. 1997;  99 1771-1774
  • 23 Vega S, Smartt Jr J M, Jiang S et al.. 500 Consecutive patients with free TRAM flap breast reconstruction: a single surgeon's experience.  Plast Reconstr Surg. 2008;  122 329-339
  • 24 Kroll S S, Schusterman M A, Reece G P et al.. Timing of pedicle thrombosis and flap loss after free-tissue transfer.  Plast Reconstr Surg. 1996;  98 1230-1233
  • 25 Gill P S, Hunt J P, Guerra A B et al.. A 10-year retrospective review of 758 DIEP flaps for breast reconstruction.  Plast Reconstr Surg. 2004;  113 1153-1160
  • 26 Namba Y, Takahashi Y, Ito S, Koshima I. Multiple vascular anastomoses with vein grafts for salvage of congestive flaps.  J Reconstr Microsurg. 2003;  19 531-536
  • 27 Chen H-C, Demirkan F, Wei F C, Cheng S L, Cheng M H, Chen I H. Free fibula osteoseptocutaneous-pedicled pectoralis major myocutaneous flap combination in reconstruction of extensive composite mandibular defects.  Plast Reconstr Surg. 1999;  103 839-845
  • 28 Benacquista T, Kasabian A K, Karp N S. The fate of lower extremities with failed free flaps.  Plast Reconstr Surg. 1996;  98 834-840 discussion 841-842
  • 29 Yajima H, Tamai S, Ono H, Kizaki K. Vascularized bone grafts to the upper extremities.  Plast Reconstr Surg. 1998;  101 727-735 discussion 736-737
  • 30 Muramatsu K, Shigetomi M, Ihara K, Kawai S, Doi K. Vascular complication in free tissue transfer to the leg.  Microsurgery. 2001;  21 362-365
  • 31 Arai K, Toh S, Tsubo K, Nishikawa S, Narita S, Miura H. Complications of vascularized fibula graft for reconstruction of long bones.  Plast Reconstr Surg. 2002;  109 2301-2306
  • 32 De Souza B A, Barret J. Beware venous backflow in head and neck cancer reconstruction.  Plast Reconstr Surg. 2004;  113 1875
  • 33 Demirseren M E, Yenidunya M O, Yenidunya S. Island rat groin flaps with twisted pedicles.  Plast Reconstr Surg. 2004;  114 1190-1194
  • 34 Haramoto U, Ohyama T, Hosokawa K, Inohara H. A case of free flap failure and internal jugular vein occlusion.  Plast Reconstr Surg. 1998;  102 1769-1770
  • 35 Shaw R J, Rogers S N. Venous microvascular anastomotic failure due to prothrombin gene mutation.  Plast Reconstr Surg. 2005;  115 1451-1452
  • 36 Aharinejad S, Dunn R M, Fudem G M et al.. The microvenous valvular anatomy of the human dorsal thoracic fascia.  Plast Reconstr Surg. 1997;  99 78-86
  • 37 Nahabedian M Y, Momen B, Manson P N. Factors associated with anastomotic failure after microvascular reconstruction of the breast.  Plast Reconstr Surg. 2004;  114 74-82
  • 38 Hirigoyen M B, Urken M L, Weinberg H. Free flap monitoring: a review of current practice.  Microsurgery. 1995;  16 723-726 discussion 727
  • 39 Kelly J L, Eadie P A, Orr D, Al-Rawi M, O'Donnell M, Lawlor D. Prospective evaluation of outcome measures in free-flap surgery.  J Reconstr Microsurg. 2004;  20 435-438 discussion 439
  • 40 Khouri R K. Avoiding free flap failure.  Clin Plast Surg. 1992;  19 773-781
  • 41 Chen K-T, Mardini S, Chuang D C et al.. Timing of presentation of the first signs of vascular compromise dictates the salvage outcome of free flap transfers.  Plast Reconstr Surg. 2007;  120 187-195
  • 42 Janezic T F, Arnez Z M, Solinc M, Zaletel-Kragelj L. One hundred sixty-seven thumb replantations and revascularisations: early microvascular results.  Microsurgery. 1996;  17 259-263
  • 43 Evans B CD, Evans G RD. Microvascular surgery.  Plast Reconstr Surg. 2007;  119 18e-30e
  • 44 Chubb D, Rozen W M, Whitaker I S, Acosta R, Grinsell D, Ashton M W. The efficacy of clinical assessment in the postoperative monitoring of free flaps: a review of 1140 consecutive cases.  Plast Reconstr Surg. 2010;  125 1157-1166
  • 45 Whitaker I S, Rozen W M, Chubb D et al.. Postoperative monitoring of free flaps in autologous breast reconstruction: a multicenter comparison of 398 flaps using clinical monitoring, microdialysis, and the implantable Doppler probe.  J Reconstr Microsurg. 2010;  26 409-416
  • 46 Paydar K Z, Hansen S L, Chang D S, Hoffman W Y, Leon P. Implantable venous Doppler monitoring in head and neck free flap reconstruction increases the salvage rate.  Plast Reconstr Surg. 2010;  125 1129-1134
  • 47 Rosenberg J J, Fornage B D, Chevray P M. Monitoring buried free flaps: limitations of the implantable Doppler and use of color duplex sonography as a confirmatory test.  Plast Reconstr Surg. 2006;  118 109-113 discussion 114-115
  • 48 Yap L H, Constantinides J, Butler C E. Venous thrombosis in coupled versus sutured microvascular anastomoses.  Ann Plast Surg. 2006;  57 666-669
  • 49 Tsao C-K, Chen H C, Chuang C C, Chen H T, Mardini S, Coskunfirat K. Adequate venous drainage: the most critical factor for a successful free jejunal transfer.  Ann Plast Surg. 2004;  53 229-234
  • 50 Yazar S, Chen H-C, Mardini S. Augmentation of venous drainage by a venous anastomosis for pedicled flaps.  J Reconstr Microsurg. 2008;  24 369-376
  • 51 Greene A K, Austen Jr W G, May Jr J W. Flap ischemia after pedicled tissue transfer to a lateral thigh wound: an example of complication assessment using the end result system of E. A. Codman.  Plast Reconstr Surg. 2007;  119 1599-1603 discussion 1604-1605
  • 52 Gampper T J, Zhang F, Mofakhami N F et al.. Beneficial effect of hyperbaric oxygen on island flaps subjected to secondary venous ischemia.  Microsurgery. 2002;  22 49-52
  • 53 Hanasono M M, Butler C E. Prevention and treatment of thrombosis in microvascular surgery.  J Reconstr Microsurg. 2008;  24 305-314
  • 54 Ashjian P, Chen C M, Pusic A, Disa J J, Cordeiro P G, Mehrara B J. The effect of postoperative anticoagulation on microvascular thrombosis.  Ann Plast Surg. 2007;  59 36-39 discussion 39-40
  • 55 Chien W, Varvares M A, Hadlock T, Cheney M, Deschler D G. Effects of aspirin and low-dose heparin in head and neck reconstruction using microvascular free flaps.  Laryngoscope. 2005;  115 973-976
  • 56 Chen C M, Ashjian P, Disa J J, Cordeiro P G, Pusic A L, Mehrara B J. Is the use of intraoperative heparin safe?.  Plast Reconstr Surg. 2008;  121 49e-53e
  • 57 Hein K D, Wechsler M E, Schwartzstein R M, Morris D J. The adult respiratory distress syndrome after dextran infusion as an antithrombotic agent in free TRAM flap breast reconstruction.  Plast Reconstr Surg. 1999;  103 1706-1708
  • 58 Disa J J, Polvora V P, Pusic A L, Singh B, Cordeiro P G. Dextran-related complications in head and neck microsurgery: do the benefits outweigh the risks? A prospective randomized analysis.  Plast Reconstr Surg. 2003;  112 1534-1539
  • 59 Miyasaka M, Ichikawa K, Nishimura M et al.. Salvage operations of free tissue transfer following internal jugular venous thrombosis: a review of 4 cases.  Microsurgery. 2005;  25 191-195
  • 60 Bui D T, Cordeiro P G, Hu Q Y, Disa J J, Pusic A, Mehrara B J. Free flap reexploration: indications, treatment, and outcomes in 1193 free flaps.  Plast Reconstr Surg. 2007;  119 2092-2100
  • 61 Hidalgo D A, Jones C S. The role of emergent exploration in free-tissue transfer: a review of 150 consecutive cases.  Plast Reconstr Surg. 1990;  86 492-498 discussion 499-501
  • 62 Smit J M, Acosta R, Zeebregts C J, Liss A G, Anniko M, Hartman E H. Early reintervention of compromised free flaps improves success rate.  Microsurgery. 2007;  27 612-616
  • 63 Wheatley M J, Meltzer T R. The role of vascular pedicle thrombectomy in the management of compromised free tissue transfers.  Ann Plast Surg. 1996;  36 360-364
  • 64 Braam M J, Cooley B C, Gould J S. Topical heparin enhances patency in a rat model of arterial thrombosis.  Ann Plast Surg. 1995;  34 148-151 discussion 151-153
  • 65 Chen L E, Seaber A V, Korompilias A V, Urbaniak J R. Effects of enoxaparin, standard heparin, and streptokinase on the patency of anastomoses in severely crushed arteries.  Microsurgery. 1995;  16 661-665
  • 66 Iglesias M, Butrón P. Local subcutaneous heparin as treatment for venous insufficiency in replanted digits.  Plast Reconstr Surg. 1999;  103 1719-1724
  • 67 MacGill K A. The “chemical leech” revisited.  Plast Reconstr Surg. 2000;  105 2272-2273
  • 68 Barnett G R, Taylor G I, Mutimer K L. The “chemical leech”: intra-replant subcutaneous heparin as an alternative to venous anastomosis. Report of three cases.  Br J Plast Surg. 1989;  42 556-558
  • 69 Robinson C. Artificial leech technique.  Plast Reconstr Surg. 1998;  102 1787-1788
  • 70 Hanasono M M, Ogunleye O, Yang J S, Hartley C J, Miller M J. Changes in blood velocity following microvascular free tissue transfer.  J Reconstr Microsurg. 2009;  25 417-424
  • 71 Har-Shai Y, Karmeli R, Saute M et al.. Distal arteriovenous fistula to maintain patency of the venous drainage of a latissimus dorsi flap following subclavian vein repair.  Plast Reconstr Surg. 2001;  107 514-518
  • 72 Johnson V, Eiseman B. Evaluation of arteriovenous shunt to maintain patency of venous autograft.  Am J Surg. 1969;  118 915-920
  • 73 Schramek A, Hashmonai M. Distal arteriovenous fistula for prevention of occlusion of venous interposition grafts to veins.  J Cardiovasc Surg (Torino). 1974;  15 392-395
  • 74 Yenidunya M O et al.. Location and length of arteriovenous fistulas around axial-pattern skin-flap pedicles.  J Reconstr Microsurg. 2001;  17 519-530
  • 75 Hage J J, Monstrey S. Free-flap distal arteriovenous fistula: when to close it?.  J Reconstr Microsurg. 1998;  14 407-410
  • 76 Gordley K P, Norris M E. Salvage of fibular osteocutaneous flap with creation of arteriovenous fistula.  Ann Plast Surg. 2008;  60 154-156
  • 77 Hammond D C, Bouwense C L, Hankins W T, Maxwell-Davis G S, Furdyna J, Capraro P A. Microsurgical replantation of the amputated nose.  Plast Reconstr Surg. 2000;  105 2133-2136 quiz 2137 discussion 2138

Neil F JonesM.D. F.R.C.S. 

University of California, Irvine, Department of Orthopaedic Surgery

101 The City Drive South, Pavilion III, Orange, CA 92868

Email: nfjones@uci.edu

    >