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DOI: 10.1055/s-0030-1261953
© Georg Thieme Verlag KG Stuttgart · New York
Physical Activity does not Influence the Effect of Antioxidant Supplementation at Nutritional Doses on the Incidence of Impaired Fasting Glucose: A 7.5 Year Post-hoc Analysis from the SU.VI.MAX Study
Publication History
received 27.04.2010
accepted 24.06.2010
Publication Date:
27 July 2010 (online)
![](https://www.thieme-connect.de/media/hmr/201011/lookinside/thumbnails/10.1055-s-0030-1261953-1.jpg)
Abstract
Supplementation with high doses of antioxidant vitamins prevents the insulin-sensitizing effects of physical exercise. However, little is known whether antioxidant supplementation affects the incidence of impaired fasting glucose (IFG). Data from 8 938 subjects included in a randomized controlled trial on supplementation with antioxidants vitamins and trace elements at nutritional doses (SU.VI.MAX) were used to examine the effects of antioxidants on incident IFG after 7.5 years of follow-up, with and without stratification for daily physical exercise. The odds-ratio (95% CI) for developing an IFG among study participants receiving antioxidant supplementation was 1.34 (0.90–1.97) (p=0.33), in comparison to placebo. This risk did not vary significantly according to physical activity level (p for homogeneity=0.10). Supplementation with trace elements and antioxidants at nutritional doses apparently does not affect the incidence of IFG irrespective of self-reported physical exercise habits.
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Correspondence
M. Ristow
Institute of Nutrition
Department of Human Nutrition
Dornburger Straße 29
07743 Jena
Germany
Phone: +49/3641/949 630
Fax: +49/3641/949 632
Email: mristow@mristow.org