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Synthesis
DOI: 10.1055/a-2774-3054
Paper

Synthesis of the Pentasaccharide Repeating unit Corresponding to the Cell-wall O-antigenic Polysaccharide of Oral Bacteria Porphyromonas circumdentaria NCTC 12469

Authors

  • Saikat Dogra

    1   Department of Chemical Sciences, Bose Institute, Kolkata, India (Ringgold ID: RIN30141)

  • Anup Kumar Misra

    1   Department of Chemical Sciences, Bose Institute, Kolkata, India (Ringgold ID: RIN30141)
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Graphical Abstract

Abstract

A concise chemical synthetic strategy has been developed for the synthesis of the pentasaccharide repeating unit of the cell-wall O-antigen of Porphyromonas circumdentaria NCTC 12469, which plays an important role in the development of periodontal disease. Several regio- and stereoselective glycosylations were carried out with high yields and satisfactory stereochemistry at the glycosidic linkages using suitably functionalized thioglycoside intermediates as glycosyl donors.

Keywords

Carbohydrates - Glycosides - Glycosylation - Total synthesis - Oligosaccharides

Supplementary Material



Publication History

Received: 10 November 2025

Accepted after revision: 10 December 2025

Article published online:
16 January 2026

© 2026. Thieme. All rights reserved.

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

 

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