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Synthesis
DOI: 10.1055/a-2741-9499
DOI: 10.1055/a-2741-9499
Short Review
Recent Advances in Catalytic Hydroamidation Reactions of Unsaturated Substrates with Dioxazolones
Autor*innen
Financial support was received from the Basic Research Program of Jiangsu (BK20251604), the Jiangsu Funding Program for Excellent Postdoctoral Talent (2025ZB280), the Wuxi Science and Technology Development Fund Project (K20241039), the foundation of Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, Jiangnan University (1042050205255750/008), and the Fundamental Research Funds for the Central Universities (JUSRP202501042).
Gefördert durch: The foundation of Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, Jiangnan University 1042050205255750/008
Gefördert durch: The Fundamental Research Funds for the Central Universities JUSRP202501042
Gefördert durch: The Wuxi Science and Technology Development Fund Project K20241039
Gefördert durch: The Basic Research Program of Jiangsu BK20251604
Abstract
Transition metal–catalyzed hydroamidation of alkenes and alkynes represents an efficient method for synthesizing structurally diverse amides, which are ubiquitously found in natural products, bioactive molecules, and pharmaceutical agents. In this context, dioxazolones have attracted extensive research attention as readily accessible and reactive amidating reagents. Herein, we summarize the advancements in hydroamidation reactions of alkenes and alkynes with dioxazolones, categorizing them according to the reaction mechanisms and classifying each section by the type of metal catalysts employed. We provide a comprehensive discussion of the scope and limitations, proposed mechanisms, and the opportunities for future development.
Publikationsverlauf
Eingereicht: 15. Oktober 2025
Angenommen nach Revision: 07. November 2025
Artikel online veröffentlicht:
27. November 2025
© 2025. Thieme. All rights reserved.
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