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Synlett
DOI: 10.1055/a-2718-7219
DOI: 10.1055/a-2718-7219
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Published as part of the Special Issue dedicated to Prof. S. Chandrasekaran on his
80th birthday
Contemporary Insights into Triazole Derivative Synthesis and Biological Functions
Authors
Supported by: Department of Higher Education, Government of UP Project ID-39/2024/242/sattar-4-2024-001
Abstract
Triazoles, which are nitrogen-containing heterocyclic scaffolds, are being extensively explored by medicinal chemists for their versatile pharmacological activities and serve as a requisite anchor for novel drug discovery in medicinal chemistry. Several synthetic methods for triazoles and their derivatives are reviewed, with an emphasis on advancements that optimize yield, efficiency, and structural diversity. Triazoles and their derivatives are synthesized via various synthetic strategies, including novel click synthesis, microwave-assisted synthesis, organo-catalyst, metal catalyst, metal-free, and green synthetic approaches. They show immense pharmacological potential, for instance, antibacterial, inflammatory inhibition, antioxidant, antimicrobial, and anticancer activities. This study explores 10 years (2015–2025) of data published in high-impact journals regarding sustainable synthesis and various therapeutic activities of triazoles and their derivatives, alongside their structural diversity and sensing nature.
Publication History
Received: 31 July 2025
Accepted after revision: 08 October 2025
Accepted Manuscript online:
08 October 2025
Article published online:
26 November 2025
© 2025. Thieme. All rights reserved.
Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany
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