Int J Sports Med 2019; 40(11): 711-716
DOI: 10.1055/a-0978-5139
Training & Testing
© Georg Thieme Verlag KG Stuttgart · New York

Effect of Stacked Sodium Bicarbonate Loading on Repeated All-out Exercise

Sebastiaan Dalle
1   Department of Movement Sciences, KU Leuven, Leuven, Belgium
,
Stefan De Smet
1   Department of Movement Sciences, KU Leuven, Leuven, Belgium
,
Willem Geuns
2   Bakala Academy Athletic Performance Center, KU Leuven, Leuven, Belgium
,
Bart Van Rompaye
3   Department of Applied Mathematics, Computer Science and Statistics, UGent, Gent, Belgium
,
Peter Hespel
1   Department of Movement Sciences, KU Leuven, Leuven, Belgium
2   Bakala Academy Athletic Performance Center, KU Leuven, Leuven, Belgium
,
Katrien Koppo
1   Department of Movement Sciences, KU Leuven, Leuven, Belgium
› Author Affiliations
Further Information

Publication History



accepted 05 July 2019

Publication Date:
21 August 2019 (online)

Abstract

The purpose of this study was to evaluate whether NaHCO3, administered via a 9-h stacked loading protocol (i.e. repeated supplementation with small doses in order to obtain a gradual increase in blood [HCO3 -]), has an ergogenic effect on repeated all-out exercise. Twelve physically active males were randomly assigned to receive either NaHCO3 (BIC) or placebo (PL) in a double-blind cross-over design. NaHCO3 supplementation was divided in three identical 3-h cycles: a 6.3 g bolus at the start, followed by 2.1 g doses at +1-h and +2-h, yielding a total NaHCO3 intake of 0.4 g·kg−1 BM over 9-h. At the end of each cycle, participants performed 2-min all-out cycling. Capillary blood samples were analyzed for [HCO3 -], pH and [La-]. Pre-exercise blood [HCO3 -] in PL decreased from 25.6±0.2 mmol·L−1 in bout 1 to 23.6±0.2 mmol·L−1 in bout 4, while increasing from 25.5±0.2 to 31.2±0.4 mmol·L−1 in BIC (P<0.05). Concomitantly, pre-exercise pH values gradually decreased in PL (from 7.41±0.00 to 7.39±0.01) and increased in BIC (from 7.41±0.01 to 7.47±0.01; P<0.05). Mean power output of the four bouts was higher in BIC (428±20 W) than in PL (420±20 W; P<0.05). The ergogenic effect on repeated all-out exercise occurred in the absence of gastrointestinal distress.

 
  • References

  • 1 Westerblad H. Acidosis is not a significant cause of skeletal muscle fatigue. Med Sci Sports Exerc 2016; 48: 2339-42
  • 2 Degroot M, Massie BM, Boska M, Gober J, Miller RG, Weiner MW. Dissociation of [H + ] from fatigue in human muscle detected by high time resolution 31P-NMR. Muscle Nerve 1993; 16: 91-98
  • 3 Bruton JD, JAN La, Joseph D, La J. Effects of CO2 -induced acidification on the fatigue resistance of single mouse muscle fibers at 28°C. J Appl Physiol (1985) 1998; 85: 478-483
  • 4 Bangsbo J, Madsen K, Kiens B, Richter EA. Effect of muscle acidity on muscle metabolism and fatigue during intense exercise in man. J Physiol 1996; 495: 587-596
  • 5 Fitts RH. Cellular mechanisms of muscle fatigue. Physiol Rev 1994; 74: 49-94
  • 6 Sahlin K. Muscle fatigue and lactic acid accumulation. Acta Physiol Scand Suppl 1986; 556: 83-91
  • 7 Nelson CR, Fitts RH. Effects of low cell pH and elevated inorganic phosphate on the pCa-force relationship in single muscle fibers at near-physiological temperatures. Am J Physiol Cell Physiol 2014; 306: C670-C678
  • 8 McNaughton L, Curtin R, Goodman G, Perry D, Turner B, Showell C. Anaerobic work and power output during cycle ergometer exercise: Effects of bicarbonate loading. J Sports Sci 1991; 9: 151-160
  • 9 Mainwood G, Worsmey-Brown P. The effects of extracellular pH and buffer concentration on the efflux of lactate from frog sartorius muscle. J Physiol 1975; 250: 1-22
  • 10 McNaughton LR. Bicarbonate ingestion: effects of dosage on 60 s cycle ergometry. J Sports Sci 1992; 10: 415-423
  • 11 Saunders B, Sale C, Harris RC, Sunderland C. Sodium bicarbonate and high-intensity-cycling capacity: Variability in responses. Int J Sports Physiol Perform 2014; 9: 627-632
  • 12 Gough LA, Deb SK, Sparks SA, Mcnaughton LR. Sodium bicarbonate improves 4 km time trial cycling performance when individualised to time to peak blood bicarbonate in trained male cyclists individualised to time to peak blood bicarbonate in trained male cyclists. J Sports Sci 2018; 36: 1705-1712
  • 13 Zabala M, Peinado AB, Calderon FJ, Sampedro J, Castillo MJ, Benito PJ. Bicarbonate ingestion has no ergogenic effect on consecutive all out sprint tests in BMX elite cyclists. Eur J Appl Physiol 2011; 111: 3127-34
  • 14 Burke LM, Pyne DB. Bicarbonate loading to enhance training and competitive performance. Int J Sports Physiol Perform 2007; 2: 93-97
  • 15 Carr AJ, Hopkins WG, Gore CJ. Effects of acute alkalosis and acidosis on performance: A meta-analysis. Sport Med 2011; 41: 801-814
  • 16 Edge J, Bishop D, Goodman C. Effects of chronic NaHCO3 ingestion during interval training on changes to muscle buffer capacity, metabolism, and short-term endurance performance. J Appl Physiol (1985) 2006; 101: 918-925
  • 17 Mcnaughton L, Backx K, Palmer G, Strange N. Effects of chronic bicarbonate ingestion on the performance of high-intensity work. Eur J Appl Physiol Occup Physiol 1999; 80: 333-336
  • 18 Harriss D, Macsween A, Atkinson G. Standards for ethics in sport and exercise science research: 2018 Update. Int J Sport Med 2017; 38: 1126-1131
  • 19 Burke LM. Practical considerations for bicarbonate loading and sports performance. Nestle Nutr Inst Workshop Ser 2013; 75: 15-26
  • 20 Pfeiffer B, Cotterill A, Grathwohl D, Stellingwerff T, Jeukendrup AE. The effect of carbohydrate gels on gastrointestinal tolerance during a 16-km run. Int J Sport Nutr Exerc Metab 2009; 19: 485-503
  • 21 Borg G. Perceived exertion as an indicator of somatic stress. Scand J Rehabil Med 1970; 2: 92-98
  • 22 Granier PL, Dubouchaud H, Mercier BM, Mercier JG, Ahmaidi S, Préfaut CG. Effect of NaHCO3 on lactate kinetics in forearm muscles during leg exercise in man. Med Sci Sports Exerc 1996; 28: 692-697
  • 23 Kupcis PD, Slater GJ, Pruscino CL, Kemp JG. Influence of sodium bicarbonate on performance and hydration in lightweight rowing. Int J Sports Physiol Perform 2012; 7: 11-18
  • 24 Siegler J, Gleadall-Siddall D. Sodium bicarbonate ingestion and repeated swim sprint performance. J Strength Cond Res 2010; 24: 3105-3111
  • 25 Vanhatalo A, McNaughton LR, Siegler J, Jones AM. Effect of induced alkalosis on the power-duration relationship of “all-out” exercise. Med Sci Sports Exerc 2010; 42: 563-70
  • 26 Bishop D, Edge J, Davis C, Goodman C. Induced metabolic alkalosis affects muscle metabolism and repeated-sprint ability. Med Sci Sports Exerc 2004; 36: 807-813
  • 27 Costill D, Verstappen F, Kuipers H, Jansson E, Fink W. Acid-base balance during repeated bouts of exercise: Influence of HCO3 . Int J Sports Med 1984; 5: 228-231
  • 28 Lavender G, Bird SR. Effect of sodium bicarbonate ingestion upon repeated sprints. Br J Sports Med 1989; 23: 41-45
  • 29 Mckenzie DC, Coutts KD, Stirling DR, Hoeben HH, Kuzara G. Maximal work production following two levels of artificially induced metabolic alkalosis. J Sports Sci 1986; 4: 35-38
  • 30 Miller P, Robinson AL, Sparks SA, Bridge CA, Bentley DJ, McNaughton LR. The effects of novel ingestion of sodium bicarbonate on repeated sprint ability. J Strength Cond Res 2016; 30: 561-568
  • 31 Mündel T. Sodium bicarbonate ingestion improves repeated high-intensity cycling performance in the heat. Temperature (Austin) 2018; 5: 343-347
  • 32 Zabala M, Requena B, Sanchez-Munoz C. et al. Effects of sodium bicarbonate ingestion on performance and perceptual responses in a laboratory-simulated BMX cycling qualification series. J Strength Cond Res 2008; 22: 1645-53
  • 33 Gaitanos G, Williams C, Boobis L, Brooks S. Human muscle metabolism maximal exercise. J Appl Physiol (1985) 1993; 75: 712-719
  • 34 Krause U, Wegener G. Control skeletal of glycolysis in vertebrate muscle during exercise. Am J Physiol Regul Integr Comp Physiol 1996; 270: R821-R829
  • 35 Valeur J, Julsrud J. Vomiting: a physiological response to acidosis?. Scand J Gastroenterol 2013; 48: 1103-1104
  • 36 Freis T, Hecksteden A, Such U, Meyer T. Effect of sodium bicarbonate on prolonged running performance: A randomized, double-blind, cross-over study. PLoS One 2017; 12: e0182158
  • 37 Gough LA, Deb SK, Sparks AS, Mcnaughton LR. The reproducibility of blood acid base responses in male collegiate athletes following individualised doses of sodium bicarbonate: A randomised controlled crossover study. Sports Med 2017; 47: 2117-2127
  • 38 Breitkreutz J, Gan TG, Schneider B, Kalisch P. Enteric-coated solid dosage forms containing sodium bicarbonate as a drug substance: an exception from the rule?. J Pharm Pharmacol 2007; 59: 59-65