DOI: 10.1055/s-00000131

Synfacts

Ausgabe 12 · Volume 21 · Dezember 2025 DOI: 10.1055/s-015-62543

Synthesis of Natural Products

  • z1175

    All PDFs of this category

  • 1175

    Total Synthesis of (+)-Elisapterosin F

  • 1176

    Total Synthesis of (–)-Novofumigatonin

  • 1177

    Total Synthesis of (±)-Calyciphylline F

  • 1178

    Total Synthesis of (–)-Psychotriadine

  • 1179

    Total Synthesis of (±)-Crokonoid A

  • 1180

    Total Synthesis of (–)-Thaigranatin P

  • 1181

    Total Synthesis of (–)-Vindoline

    • Synthesis of Heterocycles

  • z1183

    All PDFs of this category

  • 1183

    Modular Access to Azabicyclo[2.2.2]octanes and Related Azabicycles

  • 1184

    A Vilsmeier–Haack Reaction to Selectively Access Nicotinaldehyde Derivatives

  • 1185

    A Mild and Irreversible Conversion of Indazoles into Benzimidazoles

  • 1186

    Efficient Access to Chiral N-Substituted Pyrrolidines

  • 1187

    Cascade Ring Expansion to Access Functionalized Lactones

  • 1188

    Robust C2-Selective Deprotonation of Pyridines

  • 1189

    Ring Structure Diversification from Quinoline N-Oxides

  • 1190

    Synthesis of Fluorinated Isoxazolines Using a New gem-Difluoroalkane Precursor

  • 1191

    Synthesis of Benzothiadiazine 1,1-Dioxides through Iodine-Mediated Oxidative Cyclization

  • 1192

    One-Pot Access to N–H β-Amino γ-Lactones via Rhodium-Catalyzed Alkene Oxyamination

  • 1193

    Pd-Catalyzed Reaction of Arylsilanes and gem-Difluorocyclopropanes with a Fluoride Source

  • 1194

    [2+2]-Cycloaddition for the Synthesis of Azetidines

    • Synthesis of Materials and Unnatural Products

  • z1195

    All PDFs of this category

  • 1195

    A Catenane-Stabilized Cyclo[48]carbon

  • 1196

    Laterally π-Extended Helical Nanographenes

  • 1197

    Narrow Deep-Blue Emitting BN/BO-Embedded Polycycles from Lithium-Free Borylation

  • 1198

    Conjugated Polymers with Planarized B=P Connectivity

  • 1199

    Triquino[3]radialene Re-visited

  • 1200

    Benzophosphole Oxides via Phosphinyl-Zincation

  • 1201

    3D-Printable Thermosets with N,O-Acetal-Enabled Degradability and Recyclability

  • 1202

    Solvent-Tuned Upcycling of Polyethylene Terephthalate to Biodegradable Polymer Monomers

  • 1203

    Preparation and Graft-Polymerization of On-Chain Polyhydroperoxides

  • 1204

    Living Cationic Polymerization of Oxiranes

    • Metals in Synthesis

  • z1205

    All PDFs of this category

  • 1205

    Regio- and Stereoselective trans-Hydrostannation of Terminal Alkynes Enabled by an Iron Catalyst

  • 1206

    Asymmetric Reductive Vinylation of Imines under Dinickel Catalysis

  • 1207

    Synthesis of Tetrahydropyridines via a Cu-Catalyzed Formal [5+1]-Cycloaddition of Vinylcyclopropanes

  • 1208

    Isonitriles as Alkyl Radical Precursors in Photoinduced Palladium-Catalyzed Mizoroki–Heck Cross-Coupling

  • 1209

    Ligand-Enabled Non-Directed C–H Alkenylation of Arenes with α-Trifluoromethyl Olefins

  • 1210

    Palladium-Catalyzed 1,4-syn-Chloroalkylamination of 1,3-Dienes to Access Isoquinuclidines

  • 1211

    Ruthenium-Catalyzed Regioselective [2+2] Cycloaddition of Allenes and Alkynes

  • 1212

    A Reductive Alkylation/Aldol Strategy to Access β-Hydroxy Carboxyl Compounds via Dual Catalysis

  • 1213

    Photoredox Cyclopropanation via Boryl Radical-Mediated Carbene Formation

  • 1214

    Nickel-Catalyzed Asymmetric Hydroalkylation of Unsaturated Cyclic Phosphinates

  • 1215

    Copper-Catalyzed Construction of Six-Membered Phosphorus(V) Heterocycles

  • 1216

    Samarium Diiodide Induced Radical Deuteration of Thioacids in D2O

  • 1217

    Copper-Catalyzed Radical Deoxyalkynylation of Unactivated Aliphatic Alcohols

  • 1218

    Copper-Catalyzed Hydroamination of Alkynes Leads to the Selective Synthesis of Axially Chiral Enamines

  • 1219

    A Monodentate Benzofuran Phosphine Ligand Enables Isomerization of Allylamines under Cobalt Catalysis

  • 1220

    Divergent Synthesis of Hexacyclic Heterocycles Using Gold or Silver Catalysis

  • 1221

    Diastereoselective Cyclopropanation with Catalytically Generated Alkyl−Iodine(III)-Rhodium(II) Carbynoids

  • 1222

    Iridium-Catalyzed Dynamic Kinetic Resolution/Asymmetric Hydrogenation of α-Substituted Ketones

  • 1223

    Enantioconvergent Synthesis of Alkyl Azides from α-Haloamides by Photoinduced Copper Catalysis

  • 1224

    Hydroarylation of Strained Heterobicycles via a Rhodium-Catalyzed Directed C–H Activation

  • 1225

    Synthesis of Skipped Enones by Nickel-Catalyzed Dehydrogenative Coupling of Aldehydes and Alkenes

  • 1226

    Copper-Catalyzed Regiodivergent Hydrosilylation of α, β-Unsaturated Esters

  • 1227

    Regioselective Hydro- and Haloazidation of Alkenes under Iron Photocatalysis

  • 1228

    Stereo- and Regiodivergent Hydrogenation of Allenes under Cobalt Catalysis

  • 1229

    Iridium-Catalyzed Asymmetric 1,3-Hydroalkynylation of Allylamides

  • 1230

    Synthesis of Vinylcyclobutanecarboxamides through a Pd-Catalyzed Three-Component Aminocarbonylation

    • Polymer-Supported Synthesis

  • z1231

    All PDFs of this category

  • 1231

    C−S Coupling of Thiols and Aryl Iodides Using a Copper Single-Atom Catalyst Supported on mpgCN

  • 1232

    Asymmetric Reactions Using Sc(OTf)3 or Cu(OTf)2 Supported on PyBOX-Contained COF

  • 1233

    Selective Aerobic Dehydrogenative Aromatization Using Ceria-Supported Gold Nanoparticles

  • 1234

    Synthesis of 1,2,3,4-Tetrahydroquinolines from 2-Nitrobenzaldehydes and Ketones Using Ni Nanoparticles

  • 1235

    A Polymeric Pd-BINAP Catalyst for the Buchwald–Hartwig Cross-Coupling

  • 1236

    Pd-NHC-COF Catalyzes the Suzuki–Miyaura and Mizoroki–Heck Cross-Couplings

  • 1237

    C2-Amidation of Quinoline N-Oxides Using a Nitrogen-Doped Carbon-Supported Fe Catalyst

  • 1238

    Photocatalytic Oxygenation of 2-Oxazolidinones Using an Anthraquinone–Resorcinol Based Polymer

  • 1239

    Asymmetric C3-Allylation of Tryptophols and Tryptamines Using a Polymer-Supported Ir Catalyst

  • 1240

    H+-Modulated Electrochemical Olefin Hydrogenation and Olefin Migration with Nickel Catalysts

  • 1241

    Asymmetric Transfer Hydrogenation with a Mesoporous Silica-Grafted Polymeric Ru-DPEN Catalyst

    • Organo- and Biocatalysis

  • z1243

    All PDFs of this category

  • 1243

    Harnessing Radical Polarity Effects for Hydroalkylation of Unactivated Alkenes with Amides

  • 1244

    Unlocking the (ene–endo)-Mode of Carbonyl–Ene Cyclizations

  • 1245

    Flavin-Catalyzed Generation of p-Quinone Methides for Benzylic Functionalization of Phenols

  • 1246

    Regio- and Stereoselective Dehydration of Tertiary Vinyl Alcohols – More than Kinetic Resolution

  • 1247

    Chiral Disulfide Catalyst for Enantioselective Anti-Markovnikov Hydrophosphinylation

  • 1248

    N-Heterocyclic Carbene Enabled Umpolung Strategy for Constructing Rigid Bicyclic Scaffolds

  • 1249

    Asymmetric Synthesis of Sulfonimidoyl Derivatives via Control of Sulfur(VI) Stereogenicity

  • 1250

    Class I Unspecific Peroxygenase Catalyzed Conversion of Furans into Pyrrolinones

  • 1251

    Organocatalyzed Synthesis of BN-2,1-Azaboranaphthalenes via a Wolff-Type Rearrangement

    • Innovative Drug Discovery and Development

  • z1253

    All PDFs of this category

  • 1253

    Facile Nitrone Synthesis Enables Bioorthogonal Payload Delivery

  • 1254

    Conversion of Primary Aliphatic Amines into Alkyl Halides

  • 1255

    Cs2CO3-Mediated Metal-Free Nitrogen Heterocycle Synthesis

  • 1256

    Directing-Group-on-Leaving-Group Strategy Enables General and Stereospecific Glycosylation

  • 1257

    PULIng It Together: Self-Condensation Photoassembly of Pyronin Dyes for Super-Resolution Microscopy

  • 1258

    Improved Synthesis of Resmetirom

  • 1259

    Single-Component Guanidinium Transporters Enable Directed mRNA Delivery

  • 1260

    Novel Multi-Target-Directed Derivatives as Potential Therapeutic for Alzheimer’s Disease

  • 1261

    Design of Theranostic Prodrug for Targeted Imaging and Drug Delivery

    • Peptide Chemistry

  • z1263

    All PDFs of this category

  • 1263

    Photocatalytic Side-Chain Deprotection in SPPS via Fmoc/Pic Chemistry: A Sustainable Alternative to TFA

  • 1264

    Tris(2,2,2-trifluoroethoxy)silane: A New Reagent for N-Terminal Free Peptide Synthesis

  • 1265

    A Reusable Sulfonate Derivative of HOAt for Efficient Amide Bond Formation

  • 1266

    Synthesis of Unnatural α-Amino Acid Esters Utilizing a Half-Sandwich Chiral-at-Ruthenium Aldehyde Catalyst

  • 1267

    Synthesis of 13C-Labeled α-Amino Acids via Visible-Light-Driven Benzylic C(sp3)–H Carboxylation

  • 1268

    Synthesis of α-Amino Esters by Enantioselective N–H Insertion of Sulfonamides and Carbamates

  • 1269

    Photocatalytic Late-Stage Modification of Tryptophan-Containing Peptides

  • 1270

    Native Chemical Ligation of Oligopeptides Using α-Ketoacids and Cyclic Hydroxylamine

  • 1271

    Claisen Rearrangement for the Synthesis of γ,δ-Unsaturated Amino Acid Esters

    • Flow Chemistry

  • z1273

    All PDFs of this category

  • 1273

    UV-B Initiated Decarboxylative Synthesis of Trisubstituted Oxazoles in Flow