DOI: 10.1055/s-00000083

Synlett

Ausgabe 16 · Volume 36 · Oktober 2025 DOI: 10.1055/s-015-62247

Editorial

III
Editorial

table of contents

VIII
Linked PDF of Table of Contents

account

Small Molecules in Medicinal Chemistry

2381
MacQueen, Jordan; Billingsley, Kelvin L.: Indolactam Alkaloids: Syntheses and Emerging Therapeutic Applications
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2393
Sharma, Anu; Vadodariya, Palak K.; Vaddoriya, Vaidehi N.; Dhameliya, Tejas M.: Comprehensive Updates on Antitubercular Endeavors Identified in 2023
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2411
Abonia, Rodrigo; Laali, Kenneth K.: A Tale of Drug Discovery: Synthesis, Bioassay, and Computational Docking Studies of Novel Curcuminoids
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2437
Thaker, Aanal; Patel, Shrusti; Dey, Rajdeep; Shaw, Suman; Bhatt, Hardik; Patel, Bhumika; Chaube, Udit: Advancements in mTOR Inhibitors for Non-Small-Cell Lung Cancer: Mechanisms, Efficacy, and Future Perspectives
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2453
Pal, Deepti; Yadav, Shruti; Verma, Abhishek Kumar; Maurya, Sushil K.: Recent Developments in the Synthesis of Triazoles and Their Applications in Antibacterial Drug Discovery
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2473
Majhi, Sasadhar: Sustainable Approaches for the Synthesis of Functionalized Xanthene Derivatives with Anticancer Activities Using Modern Green Tools at Room Temperature: Less Energy and More Efficiency
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perspectives

Small Molecules in Medicinal Chemistry

2499
Sanjaykumar, Randhe Siddhant; Basavaraj, Chavan Sagar; Arshad, Anam Sania Md.; Singh, Rohit; Mahindroo, Neeraj: A Decade of FDA-Approved Pharmacophore-Based Small Molecules: Advances in Medicinal Chemistry from 2014 to 2024
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2527
Goel, Kapil Kumar; Singhal, Peeush; Sathish, Elagandhula; Babu, M. Arockia; Pandey, Sarvesh Kumar; Tyagi, Yogita; Kumar, Roshan; Singh, Thakur Gurjeet; Puri, Sarthak: A Minireview on the Morpholine-Ring-Containing U.S. FDA Approved Drugs: A Medicinal-Chemistry-Based Analysis from 2013 to 2023
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2537
Chandra, Devesh; Sachin, Sachin; Rav, Shourabh; Sharma, Upendra: Quinoline-Based FDA-Approved Drugs: Synthetic Route and Clinical Uses
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letter

Small Molecules in Medicinal Chemistry

2553
Garg, Aakriti; Bhattacharya, Bireswar; Samanta, Uttam; Singha, Subhankar; Ghosh, Dipanjan; Bhowmik, Subhendu; Jaisankar, Parasuraman; Gupta, Sreya: Phototriggered Migration of Indole-Based Cationic Fluorophore from Mitochondria to Nucleolus in Live Cells
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Supporting Information
2559
Alaeddini, AmirHossein; Karimian, Somaye; Noori, Milad; Dastyafteh, Navid; Mohammadi-Khanaposhtani, Maryam; Ghomi, Minoo Khalili; Bararjanian, Morteza; Iraji, Aida; Javanshir, Shahrzad; Larijani, Bagher; Ranjbar, Parviz Rashidi; Mahdavi, Mohammad: Design, Synthesis, Enzymatic Inhibition, and Antioxidant Activity of New 4-Phenylpiperazin-phenoxy-1,2,3-triazol-acetamide Derivatives as Tyrosinase Inhibitors
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Supporting Information
2565
Ito, Toshiya; Kinoshita, Kazutomo; Tomizawa, Masaki; Shinohara, Shojiro; Nishii, Hiroki; Tanaka, Hiroshi; Kuramoto, Shino; Oikawa, Nobuhiro: Development of a Novel Tropomyosin Receptor Kinase Inhibitor Based on Structure–Activity Relationships: Identification of a Promising Clinical Candidate
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Supporting Information
2573
Haque, Rajibul; Ghosh, Souma; Banerjee, Rajkumar; Maity, Debabrata: Reactive Probe for Fluorescent Detection of Norepinephrine Based On an Excited-State Intramolecular Proton Transfer (ESIPT) Mechanism
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Supporting Information
2577
Shaw, Suman K.; Dey, Rajdeep; Yadav, Ruchi; Baldiwala, Aliasgar; Patel, Manan; Patel, Bhumika D.; Bhatt, Hardik G.; Natesan, Gopal; Jha, Abhishek; Chaube, Udit: Exploring Tetrahydroquinoline Derivatives: A New Frontier in Cancer Treatment
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Supporting Information
2585
Hamdy, Ahmed K.; Araki, Hiroshi; Tateishi, Hiroshi; Toma, Tsugumasa; Radwan, Mohamed O.; Biswas, Shashwata; Kuwata, Takeo; Matsushita, Shuzo; Fujita, Mikako; Niwa, Shin-ichiro; Otsuka, Masami: Synthesis of a 5,6-Dihydropyran-2-one Derivative with Dual Anti-Cell-Migration and Anticancer Activity
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Supporting Information
2591
Roy, Sudipta; Kalita, Gitumoni; Maharana, Satyapriya; Chatterjee, Arunima; Jana, Rathin; Nath, Naba K.; Chatterjee, Paresh Nath: A Green Approach to 2-Amino-4H-chromenes by Calcium Lactate Catalyzed, One-Pot, Three-Component Reactions
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Supporting Information
2597
Peprah, Paul K.; Spitznagel, Brittany D.; Du, Yu; Nguyen, Dalena; Weaver, C. David; Emmitte, Kyle A.: Efficient Regioselective Synthesis of Benzimidazoles and Azabenz­imidazoles to Enable the Rapid Development of Structure–Activity Relationships for Activation of SLACK Potassium Channels
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Open Access
Supporting Information
2603
Chvatal, Jo; Nguyen, Dat T.; Xie, Alexondra S.; Parsons, William H.: Synthesis and Evaluation of N-Arylsulfonylated Succinimides as Activity-Based Probes
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Open Access
Supporting Information
2609
Das, Debojyoti; Sadhukhan, Juheli; Mandal, Pabitra; Pramanik, Smritimoy; Kabir, Alomgir Shah; Adhikari, Susanta Sekhar: Synthesis of Novel Coumarin-Appended Dihydrothiopyrimidinones and Evaluation of Their Binding Interactions with Bovine Serum Albumin
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Supporting Information
2615
Milokhov, Demyd S.; Pomalin, Mykhailo S.; Lutsiuk, Tetiana M.; Hys, Vasyl Y.; Virych, Pavlo A.; Poliudov, Anton O.; Popova, Maria V.; Shishkina, Svitlana V.; Volovenko, Yulian M.; Dobrydnev, Alexey V.: Benzo[d][1,2]thiazepin-5-one 3-Oxides: An Unexplored Scaffold with Anticancer Activity
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Supporting Information
2623
Şenol, Halil; Çağman, Zeynep; Çakır, Furkan; Tokalı, Feyzi Sinan: Synthesis, Characterization, and In Vitro and In Silico Biological Evaluation of Novel Polyphenols Bearing a Quinazolin-4(3H)-one Ring as Promising Anti-Prostate-Cancer Agents
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Supporting Information
2631
Khanka, Sonu; Rawat, Kundan S.; Pandey, Priyanka; Pal, Shyamal; Vats, Ravi P.; Rathur, Rajat; Sharma, Kriti; Dipali, Divya; Singh, Divya; Goel, Atul: An Efficient Synthesis of 3-Aryl-2H-chromene Derivatives as Potential Bone Anabolic Agents
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Supporting Information
2637
Shaikh, Arbaz Sujat; Rathod, Mahipal Singh; Vemula, Divya; Makhal, Priyanka N.; Bhandhari, Vasundhara; Kaki, Venkata Rao: Metal-Free Amidation and Selenoamidation of 2-Methylquinolines with Secondary Amines Using Selenium Dioxide, and Antibacterial Evaluation of the Products
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Supporting Information
2643
Sengar, Neha; Chatterjee, Joydeep; Kumar, Raj; Singh, Inder Pal: Synthesis and Evaluation of Bakuchiol-Tethered Triazoles as Cytotoxic Agents
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Supporting Information
2647
Kaboudin, Babak; Poordehghan, Ali; Ghashghaee, Mojtaba; Fukaya, Haruhiko: A Novel Condensation–Cyclization Reaction of 4-Chloro-3-formylcoumarin with Amidoximes: Facile Synthesis of Coumarin-Fused Pyrimidinones
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Supporting Information
2651
Wu, Zhongzhi; Li, Wei: A Practical and Highly Efficient Procedure for the Synthesis of the Trifluoromethylpyrazol-Derived Canonical Transient Receptor ­Potential Channel (TRPC3) Inhibitor Pyr3 and Its Derivatives
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Supporting Information
2655
Toledano-Pinedo, Mireia; Diez-Iriepa, Daniel; Porro-Pérez, Alicia; Schäker-Hübner, Linda; Hanl, Maria; Samadi, Abdelouahid; Almendros, Pedro; Iriepa, Isabel; Rodríguez-Fernández, M. Mercedes; Griñán-Ferré, Christian; Siwek, Agata; Wolak, Małgorzata; Satała, Grzegorz; Bojarski, Andrzej J.; Doroż-Płonka, Agata; Handzlik, Jadwiga; Godyń, Justyna; Knez, Damijan; Gobec, Stanislav; Więckowska, Anna; Hansen, Finn K.; Marco-Contelles, José: Contilistat, a New Multitarget Small Polyfunctionalized Indole Derivative
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Supporting Information
2661
Candito, David A.; Simov, Vladimir; Liu, Ping; Ardolino, Michael J.; Martinot, Theodore; Lyons, Thomas; Qi, Ji; Yin, Jingjun; Hao, Jinglai; Hu, Bin; Chen, Meng; Zhang, Jun; Lam, Yu-hong; Fuller, Peter H.; Ellis, J. Michael; Maddess, Matthew: A Concise Synthesis of a Key Azabicyclo[2.1.1]hexane Building Block for N-Heteroaryl Indazole LRRK2 Kinase Inhibitors
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Supporting Information
2666
Beveridge, Julia; Söderström, Marcus; Balestri, Lorenzo Jacopo Ilic; Prieto-Díaz, Rubén; Gutierrez-de-Teran, Hugo; Odell, Luke R; Hallberg, Mathias; Larhed, Mats; Gising, Johan: Benzylhydroxamic Acids as IRAP Inhibitors: Sulfonamide Variations
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Open Access
Supporting Information

errata

e3
Hamdy, Ahmed K.; Araki, Hiroshi; Tateishi, Hiroshi; Toma, Tsugumasa; Radwan, Mohamed O.; Biswas, Shashwata; Kuwata, Takeo; Matsushita, Shuzo; Fujita, Mikako; Niwa, Shin-ichiro; Otsuka, Masami: Erratum: Synthesis of a 5,6-Dihydropyran-2-one Derivative with Dual Anti-Cell-Migration and Anticancer Activity