DOI: 10.1055/s-00000131

Synfacts

Issue 03 · Volume 20 · March 2024 DOI: 10.1055/s-014-59119

Synform

A036
Zanda, Matteo: SYNFORM ISSUE 2024/03

Synthesis of Natural Products

z0223
All PDFs of this category
0223
Total Synthesis of (–)-Cephalocyclidin A
0224
Synthesis of Calyciphylline A-Type and Macrodaphniphyllamine-Type Alkaloids
0225
Total Synthesis of (+)-Rhodomollin A
0226
Enantioselective Total Synthesis of (+)-Euphorikanin A
0227
Synthesis of (–)-Garryine
0228
Total Synthesis of (+)-Arboduridine
0229
Total Synthesis of (–)-Magellanine

Synthesis of Heterocycles

z0231
All PDFs of this category
0231
Strained exo-Methylene Heterocycles as Dipolarophiles: Synthesis of Unexplored Spiroisoxazolines
0232
Multicomponent Synthesis of Tetrahydroisoquinolines
0233
Synthesis of 2-Alkylmethyl Pyrroline Derivatives
0234
Sc(OTf)3‑Catalyzed Cycloadditions for the Synthesis of Substituted Indolines
0235
Gram-Scale, Modular Access to C2-Bis(Oxazoline) Ligands
0236
Multicomponent Synthesis of Quinolines via Hydrogen-Transfer Reaction
0237
A Highly Diastereoselective Synthesis of Sulfur-Containing Unnatural Amino Acids
0238
Efficient, Epimerization-Free Solid-Phase Peptide Synthesis
0239
Versatile Synthesis of Tertiary and Heterocyclic and Aromatic Amines
0240
Practical and Efficient Access to Multifunctional BCPs
0241
Synthesis of 2,5-Disubstituted Pyridines via Gold(I)-Catalyzed Cycloisomerization of 1-Bromoalkynes
0242
Nitrogen Atom Insertion into Arenols in the Synthesis of Benzazepines
0243
Palladium-Mediated Synthesis of 3-Methylindoles Under Mild Conditions

Synthesis of Materials and Unnatural Products

z0245
All PDFs of this category
0245
2-Center-3-Electron π-Bond without a σ-Bond
0246
Aryne-Activated Smiles Rearrangement of Anilines
0247
Hydroaminoalkylation of Polybutadiene
0248
Iterative Binomial Synthesis of Monodisperse Conjugated Polymers
0249
Alternating Poly(Lactic-co-Glycolic Acid) from Racemates
0250
Phenanthridines from Oxime Esters
0251
1,3-Azaphospholes
0252
Chloride-Directed Enantioselective C(sp2)–H Borylation
0253
Macrocycle Skeletal Rearrangement of a Cationic Borane
0254
Facile Synthesis of Indolocarbazole from Indoles
0255
Heptagon Annulation via C−H Activation
0256
A Neutral 2π-Aromatic Si2B2 Ring

Metals in Synthesis

z0257
All PDFs of this category
0257
Wittig-Type E-Selective Olefination of Imines with Vinyl Boronate Esters Under Copper Hydride Catalysis
0258
Cyanation of Allenes via Copper-Catalyzed Site-Selective C(sp2)–H Hydrogen Atom Abstraction
0259
Regioselective C(sp³)–H Activation of Cyclic Aliphatic Acids: Synthesis of Unsaturated Bicyclic Lactones
0260
Acylation of Unactivated C(sp3)–H Bonds with Acyl Azolium Reagents under Photoinduced Cerium Catalysis
0261
Rhodium Catalyzed Three-Component Coupling Annulation of 2-Aryloxazolines
0262
Asymmetric Synthesis of Eight-Membered N-Hetero-cycles by Palladium-Catalyzed (4+4) Cycloaddition
0263
Divergent Multicomponent Fluoroalkylative Carbonylation of 1,3-Enynes Under Palladium Catalysis
0264
An Electroreductive Strategy for the Hydroxy Fluorosulfonylation of Alkenes
0265
Regioselective C(sp2)–H Borylation of (Hetero)Arenes under Cobalt Catalysis
0266
Iron-Catalyzed Coupling of Allylic Dithianes with Alkynylsilanes Involving a Dithiane Rearrangement
0267
Tetracyclic Cycloheptanols Synthesis via Rhodium-Catalyzed Cascade Reaction
0268
Cobalt-Catalyzed Synthesis of Amines via Nitriles Electrohydrogenation
0269
Hiyama Cross-Coupling of gem-Difluoroalkenes: Stereoselective Synthesis of Tetrasubstituted Olefins
0270
Copper-Catalyzed Suzuki–Miyaura Cross-Couplings of Unactivated Alkyl Halides
0271
Photoenzymatic Catalyzed Coupling of Amino Acids with Vinylpyridines
0272
Carbonylation/Amination of Alkylidenecyclopropanes Towards Eight-Membered Benzolactams
0273
Electrophotochemical Decarboxylative Vinylation of Carboxylic Acids under Dual Cerium and Nickel Catalysis
0274
Enantioselective α-Alkylation of Enolizable Ketones with Alkyl Iodides under Bimetallic Nickel Catalysis
0275
Nickel-Catalyzed Silylalkylation of Unactivated Terminal Alkenes
0276
Enantioselective Synthesis α-Gem-Difluorinated Alcohols via Rh(III)-Catalyzed Transfer Hydrogenation
0277
Asymmetric Hydroacylation of Internal Olefins and Aldehydes
0278
Alkyllithium- and Magnesium Salt-Assisted 1,1- and 1,3-Aminoboration of Alkenes under Nickel Catalysis
0279
Iridium Photoredox-Catalyzed Nitrative Difunctionalization of Alkenes
0280
Sequential Cu-Borylation Strategy for a Stereodivergent Synthesis of Functionalized Cyclohexanones
0281
Synthesis of Linear Aliphatic Amides via Rh-Catalyzed Hydroamidation of Internal Olefins
0282
Iron-Photocatalyzed C(sp2)–H Trifluoromethylation of (Hetero)Arenes with Trifluoroacetates
0283
The First Use of Aryltrimethylammonium Salts in Nickel-Catalyzed Suzuki Cross-Couplings

Polymer-Supported Synthesis

z0285
All PDFs of this category
0285
Intramicellar Pd-Catalyzed β-Arylation of Thiophenes
0286
Oxidative Coupling of Amines Using a 4-Nitrophenyl­acethylene-Functionilzed Cu2O Crystal
0287
A Spirobifluorene-Based COF for Photo-Induced Nickel-Catalysed Amination of Aryl Halides
0288
Photocatalytic Synthesis of 1,3-Diarylated Imidazo[1,5-a]pyridines with Carbon Nitride
0289
Photocatalytic Dehalogenative Deuteration and Hydrogenation of Halides by a Chromium-Based MOF
0290
Nitriles and Amides Synthesis from 1,2-Diols by N-Doped Porous Carbons
0291
Borylation of Alkyl and Aryl Halides Using CeO2 Nanorods
0292
Preparation of Alkylamines from Alcohols and Carbonyl Compounds through Reductive Amination
0293
Minisci-Type Reactions Promoted by a Zirconium-Phenazine MOF
0294
Dehydrogenative Coupling of Organosilanes with Alcohols by a Single-Atom Gold(I) Catalyst
0295
Dehydrogenative Cross-Coupling of P(O)H and Thiols by a Polyoxomolybdate Photocatalyst

Organo- and Biocatalysis

z0297
All PDFs of this category
0297
Metal-free meta-Selective C–H Amination of Arenes
0298
Acid-Catalyzed Nitromethane Activation for the Synthesis of Amides and Nitriles
0299
Enzymatic C–H Amidation toward Stereoselective Construction of β-, γ- and δ-Lactams
0300
Enantioselective C−C Bond Insertion into Aldehydes via Oxazaborolidinium Catalyzed 1,2-Acyl Shift
0301
Biocatalytic Approach for the Synthesis of Lactones via Carbene C–H Insertion
0302
Photoenzymatic Hydrosulfonylation of Olefins Initiated by Single Electron Oxidation
0303
VANOL-Derived Imidodiphosphorimidate-Catalyzed Bromospiroketalization
0304
Stereoselective α-Benzylation of Cyclic Ketones via Chemoenzymatic Cascade
0305
Asymmetric Cyclizations Catalyzed by Chiral Boryl Radicals
0306
Brønsted Acid Catalyzed Aromatization-Enabled Umpolung of Imines

Innovative Drug Discovery and Development

z0307
All PDFs of this category
0307
A Rhodium-Catalyzed “Hook-and-Slide” Homologation of Amides
0308
HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors That Prematurely Activate Protease Causing Cell Death
0309
Chemoenzymatic Syntheses of Fluorine-18-Disaccharides to Image Bacterial Infection
0310
Facile Access to Bioactive Piperidine-γ-Butyrolactones
0311
Synthesis, Structural Validation, and SAR of Antifungal Fusaramin
0312
Tryptamine Derivatives of Norpsilocin Induce Psychedelic-Like Responses in Mice
0313
Novel Synthesis of Levadopa Improves Efficiency and Eliminates Use of Pyrophoric Raney Nickel
0314
Selective Installation of C1-C3 Fluorocarbons to Aldehydes
0315
Multikilogram Birch Reduction and Evaluation of Alternative Synthetic Routes to a Ketalized Cyclohexene Derivative
0316
Accessing 2-Aminophenol Derivates Using Triplet-State Nitro(hetero)arenes and Copper Photocatalysis
0317
Development of a Continuous Flow Process for Photoredox Decarboxylative Fluorination
0318
A Chiral Amide Directing Group for Ruthenium-Catalyzed Asymmetric C–H Activation
0319
Matteson Homologation-Based Total Synthesis of Meliponamycin A
0320
Discovery of the Selective KRAS G13D Inhibitors Derived from the Scaffold of KRAS G12C Inhibitor
0321
Photo-Uncaging of a Microtubule Depolymerizer Reduces Tumor Volume in a Mouse Model
0322
Photomediated Deaminative Generation of Tertiary Anions

Peptide Chemistry

z0323
All PDFs of this category
0323
Peptide Cyclization of Unprotected Peptides with Cysteine at C-Terminal
0324
Boronic Acid-Catalyzed Peptide Bond Formation from Serine- and Threonine-Derived Inert Esters
0325
Metal-Free Synthesis of α‑Tertiary Amino Acid Derivatives via Photoinduced Cross-Coupling
0326
Unnatural Peptide Synthesis through Rh(III)-Catalyzed Diastereoselective Ligation with Three Components
0327
Isothiourea-Catalyzed Conjugate Addition to Form Proline Derivatives
0328
Palladium-Catalyzed Photoinduced Alkylation for Glycine Derivatives
0329
Direct Amidation of Unprotected Amino Acids Mediated by Hexylsilane
0330
Co-Catalyzed Asymmetric Aza-Barbier Reaction: A Useful Method for α-Tertiary Amino Ester Synthesis
0331
Direct Synthesis of γ-Amino Acid Derivatives via Cobalt-Catalyzed Aminoalkylative Carbonylation of Alkenes
0332
Palladium-Catalyzed Cross-Coupling for the Synthesis of Pyridyl Amino Acids

Flow Chemistry

z0333
All PDFs of this category
0333
Continuous-Flow Heterogeneous Rhodium-Catalyzed Asymmetric Hydroacylations