DOI: 10.1055/s-00000131

Synfacts

Issue 08 · Volume 17 · August 2021 DOI: 10.1055/s-011-51432

Synform

A124
Zanda, Matteo: SYNFORM ISSUE 2021/08

Synthesis of Natural Products and Potential Drugs

z0841
All PDFs of this category
0841
Total Synthesis of (+)-Talassimidine and (+)-Talassamine
0842
Enantioselective Total Synthesis of (–)-Dysiherbol A
0843
Synthesis of Rovafovir Etalafenamide
0844
Rovafovir Etalafenamide (Part III): Synthesis of the Phosphonamidate Fragment
0845
Rovafovir Etalafenamide (Part IV): Synthesis of the Fluorinated Nucleoside Fragment
0846
Total Synthesis of (±)-Penicibilaenes
0847
Total Synthesis of (–)-Stemoamide
0848
Synthesis of GLPG2938
0849
Synthesis of Icenticaftor
0850
Synthesis of Runcaciguat
0851
Synthesis of (±)-Altemicidin
0852
Total Synthesis of (+)-Euphorikanin A
0853
Synthesis of a Bruton’s Tyrosine Kinase Inhibitor
0854
Synthesis of (±)-Panacene

Synthesis of Heterocycles

z0855
All PDFs of this category
0855
Pictet–Spengler Reaction of Ketonitrones
0856
Solvent Synthons: DMSO as an Active Methylene to Synthesize of Benzoxazines from Phenols and Nitriles
0857
Synthesis of Benzazepines through Rhodium-Catalyzed Electrocyclization
0858
Synthesis of Eight-Membered Lactams via Spiroindolines
0859
Carbon Dioxide Incorporation Catalyzed by Nickel
0860
An Elegant Synthetic Avenue to Azetidine-Containing Spirocycles
0861
Synthesis and Evaluation of Novel Nucleotide Analogues Containing Dioxane and Morpholine Rings
0862
Organocatalytic Approach to Chiral Spiro-Dihydropyranones
0863
Phosphine-Catalyzed Synthesis of Functionalized 3-Alkenyl benzofurans
0864
Synthesis of 3‑Aroylimidazo[1,2‑a]‑N‑heterocycles by Using DMSO as a One-Carbon Synthon
0865
Iron-Catalyzed Synthesis of 4-Aryl pyrrolo[1,2-a]quinoxalines from Nonactivated Methyl Arenes
0866
Fluorocyclization of Allylic Alcohols and Amines to Access 3-Functionalized Oxetanes and Azetidines
0867
Gold- and Palladium-Catalyzed Synthesis of Multifunctionalized Nine-Membered Heterocycles
0868
Selective Catalytic C-2 C–H Functionalization of Azoles

Synthesis of Materials and Unnatural Products

z0869
All PDFs of this category
0869
Masked Aryl Anions for Perfluoroarene Couplings
0870
A Lewis Base-Free Thiophosphonium Ion and Its Reactivity
0871
Highly Fluorinated Trianglimine Synthesis and Application
0872
Extremely Rigid Polymerization Catalyst for iPP
0873
Arene Shuffle in a Fluorophore-Forming Rearrangement
0874
A Choice of Hexagons or Octagons
0875
Carbon Nanobelt Synthesis Reimagined
0876
Synthesis of Cyclic Polyacetylene
0877
Synthesis of Redox-Active Polypeptides
0878
A Family of Superhelicenes
0879
Synthesis of Inorganic–Organic Hybrid Polymers
0880
Possible Segment Models for [6,6] SWCNTs

Metals in Synthesis

z0881
All PDFs of this category
0881
Photochemical Asymmetric Iridium-Catalyzed C(sp3)–C(sp3) Cross-Coupling
0882
Pyrazoline Synthesis via Addition of Diazomethyl Radical to Styrenes
0883
Sequential Catalysis for Two Remote Asymmetric Reactions
0884
Nickel-Catalyzed Cross-Electrophile Coupling Enabled by Photoinduced Fragmentation of an EDA Complex
0885
Ni-Catalyzed Stereospecific Cross-Coupling of Benzylic Carboxylates: Beyond the Naphthyl Limitation
0886
Gold-Catalyzed Access to Skipped Dienes and Enynes
0887
Decarboxylative Iodination of Carboxylic Acids
0888
Nickel-Catalyzed Cross-Coupling of Aryl Nitriles and Thiols
0889
Electrocatalytic Dehydrogenative Coupling of Aryl Carboxylic Acids
0890
Rhenium-Catalyzed Aryl-Acylation of Enol Lactones
0891
Rhodium-Catalyzed Directed Dealkenylative Arylation
0892
Palladium-Catalyzed Preparation of Atropisomeric o-Terphenyls
0893
Imidazolidin-4-one Synthesis and 1,4-Aryl Migration of 2-Azidoamides
0894
Co/Ni Dual Catalysis: Accessing New Regioselectivity for the Ring Opening of Epoxides with Aryl Halides
0895
Nickel-Catalyzed Chain Walking: From Ketones with Remote Olefins to Z-Silyl Enol Ethers
0896
Cobalt-Catalyzed Photoredox Coupling of Aldehydes and Alkynes
0897
Enantioselective Palladium-Catalyzed Oxycarbonylation of Terminal Alkenes
0898
Palladium-Catalyzed Perfluoroalkylative Aryloxycarbonylation
0899
Copper-Catalyzed Enantioselective Borylation of Dialkyl Ketimines
0900
Palladium-Catalyzed Synthesis of Indoles and Isoquinolinones from Allenamides
0901
Synthesis of Tricyclic Imidazoles Bearing a Seven-Membered Ring by Ni–Al Bimetallic Catalysis
0902
Germylzincation of Internal Alkynes
0903
A Copper-Catalyzed Synthesis of Azoheteroarenes
0904
Asymmetric Synthesis of Fluorinated Cyclopentanes by Dyotropic Rearrangement of Palladium(IV) Species
0905
Palladium-Catalyzed Alkylation of Phenol Derivatives
0906
Molybdenum-Catalyzed Deoxygenative Cyclopropanation–Cyclization Reactions
0907
Nickel-Catalyzed Tandem Isomerization/Hydroarylation of Allylarenes
0908
Asymmetric Copper-Catalyzed Diels–Alder/Retro-Diels–Alder Reaction of 2-Pyrones with Alkynes
0909
A Methylene-Bridged Titanium–Aluminium Complex for Olefinations of Carbonyls: The Tebbe Reagent

Polymer-Supported Synthesis

z0911
All PDFs of this category
0911
Heterogeneous and Recyclable Organocatalyst for Oxidation of Alcohols
0912
Photochemical Hydrodehalogenation, Arylation, and Sulfonylation on Ceramic Boron Carbonitrides
0913
Hydroxy-Group-Directed Diastereoselective Hydrogenation
0914
Oxidative Esterification of Alcohols with a Polyoxometalate-Containing Chromium Catalyst
0915
Synthesis of Acridine and Quinazoline Derivatives on an Immobilized Saponin-Copper(II) Complex
0916
Hydrosilylation of Carbonyls Catalyzed by Silica-Supported Ni3Ga
0917
Photocatalytic Coupling of Styrenes with Water-Miscible Solvents Promoted by Ag/TiO2
0918
Copper-Nanoparticle-Catalyzed Hydroboration of Alkenes and Borylation of Alkenones
0919
Photocatalytic Synthesis of Benzimidazoles on Heterogenized Coomassie Brilliant Blue
0920
The Anti-Markovnikov Wacker-Type Oxidation of Styrenes on Nanorod-Supported Single-Atom Silver

Organo- and Biocatalysis

z0921
All PDFs of this category
0921
An Organophotocatalytic Borylative Minisci Reaction
0922
Catalytic Hydrodefluorination of Trifluoromethylalkenes toward Monofluoroalkenes or gem-Difluoroalkenes
0923
Asymmetric Catalytic Carbonyl-Ene Cyclization and Acetalization
0924
Photoredox Reductive Coupling of Olefins with Aryl Chlorides through the Carbon Dioxide Radical Anion
0925
Enantioselective Aza-Sakurai Reaction through Cooperative Dual Catalysis
0926
Trisaminocyclopropenium Ion Catalyzed Electrophotocatalytic C–H Monoamination
0927
Biocatalytic Dynamic Kinetic Resolution Toward β-Branched Aromatic α-Amino Acids
0928
Organophotocatalytic Radical Dearomatization of Arenes for the Synthesis of Spirocyclic Lactams
0929
Synthesis of Morpholinones by Chiral Phosphoric Acid Catalyzed Azabenzilic Ester Rearrangement
0930
Mechanically Interlocked Charge-Transfer Catalyst Permits Visible-Light Photoredox Transformations

Chemistry in Medicine and Biology

z0931
All PDFs of this category
0931
Adding Oxygen with N-Ammonium Ylides
0932
Multiple Macrocyclization Strategies in the Syntheses of Potent Myeloperoxidase (MPO) Inhibitors
0933
Novel Antibiotics by Late-Stage Derivatization of Marketed Fidaxomicin
0934
Antimalarial Heterocycles: Tackling Chloroquine-Resistent Plasmodium falciparum
0935
A Synthetic Diterpene Against Persistent Mycobacteria and Biofilm Formation
0936
Synthesis of Bridged 4′-Thio Nucleic Acid Monomers
0937
Folate-Caged PROTACs Favor Cancer Cells
0938
Sanglifehrins and Analogs: Synthesis and Biological Evaluation of their Immunosuppressive Activity
0939
Identification of ENL YEATS Domain Inhibitors through Cell-Based Drug Discovery with SuFEx
0940
Reducing the Risk of Opioid Misuse

Peptide Chemistry

z0941
All PDFs of this category
0941
Synthesis of Azobenzene-Functionalized Peptides by Modification of Tyrosine-Containing Peptides
0942
Synthesis of 1,3-Benzoxazepines and their Conversion into o-Tyrosine Analogues
0943
Site-Selective C–H Functionalization of Tryptophan Derivatives
0944
Organocatalytic Mannich Reaction for the Synthesis of β-Amino Acid Esters
0945
Copper-Catalyzed Synthesis of Cyclic β-Amino Acids from Isoxazolidin-5-one Derivatives
0946
Palladium-Catalyzed Glycosylation of Arginine
0947
Potassium-Catalyzed Asymmetric Mannich Reaction
0948
Copper-Catalyzed Difluoromethylation of Amino Acids to Induce a New Tetrasubstituted Carbon Stereocenter
0949
Copper-Squaramide-Catalyzed Synthesis of α-Amino Acid Derivatives
0950
One-Pot Protocol for Peptide Synthesis from Unprotected or Partially Protected Amino Acids
0951
Zinc Dust Mediated Peptide Synthesis from Fmoc-Amino Acid Chlorides and Amino Acid Hydrochlorides

Flow Chemistry

z0953
All PDFs of this category
0953
Single-Flow System for Acid Hydrolysis and Base Condensation
0954
Continuous-Flow Synthesis of Isocyanides for Use in a Palladium-Catalyzed Domino Reaction
0955
Stereoselective Photocatalytic Cyclization of Bisenones
0956
Organophotocatalytic Aerobic Oxygenation under Visible-Light Irradiation
0957
Kinetic Resolution of C2-Symmetric (±)-Diols in Flow by Sequential Organocatalytic Acylation