DOI: 10.1055/s-00000131

Synfacts

Issue 09 · Volume 16 · September 2020 DOI: 10.1055/s-010-49280

Synform

A124
Zanda, Matteo: SYNFORM ISSUE 2020/09

Synthesis of Natural Products and Potential Drugs

z1009
All PDFs of this category
1009
Synthesis of BI 201420
1010
Synthesis of AMG 232
1011
Synthesis of (–)-Chilocorine C
1012
Synthesis of (–)-Dippinine B and (+)-Dippinine C
1013
Total Synthesis of (–)-Ingenamine
1014
Synthesis of ATX Inhibitor Ziritaxestat
1015
Synthesis of Rucaparib
1016
Synthesis of Delgocitinib
1017
Synthesis of MRTX849
1018
Synthesis of Zotatifin
1019
Synthesis of Lamivudine
1020
Synthesis of a NaV 1.7 inhibitor
1021
Total Synthesis of (±)-Anhydroryanodol
1022
Synthesis of BMS-929075
1023
Synthesis of BAY 1895344
1024
Synthesis of a DPP-4 Inhibitor
1025
Total Synthesis of (–)-Picrotoxinin
1026
The First Total Synthesis of (+)-Resiniferatoxin
1027
Synthesis of Dexamethasone
1028
Total Synthesis of (–)-Conidiogenone B, (–)-Conidiogenone and (–)-Conidiogenol

Synthesis of Heterocycles

z1029
All PDFs of this category
1029
Electrochemical Alkylation of Hetarenes with Carbazates as Radical Precursors
1030
Photocatalytically Triggered Radical Smiles Rearrangement
1031
Synthesis of Medium-Sized Lactones from Siloxy Alkynes and Lactols by Ring Expansion
1032
Synthesis of Spiro[cyclohexane-1,12′-isoindolo-[1,2‑b]quinazolin]-10′-one Derivatives
1033
Catalyst-Controlled Regioselective C-5 Hetarene Olefination
1034
1,4-Benzoxazepines and Tetrahydroquinolines by Pd-Catalyzed [4+2] and [5+2] Annulations
1035
Rh(III)-Catalyzed Synthesis of 6H-Benzo[c]chromen-6-ones from Sulfoxonium Ylides and Quinones
1036
Automated Photoredox 18F-Difluoromethylation of Acyclovir
1037
Titanium-Mediated Synthesis of Polysubstituted Pyrazoles
1038
Safe and Efficient Synthesis of 4-Aminofurazan-3-Carboxylic Acid and its Ethyl Ester
1039
Rhodium(III)-Catalyzed Synthesis of 1,2-Diaminobenzenes and Benzimidazoles
1040
Ruthenium-Mediated ortho-Selective C–H (Per)fluoroalkylation of Anilines and Indoles
1041
C–H Hydroxymethylation of N-Arylazaindoles with Paraformaldehyde

Synthesis of Materials and Unnatural Products

z1043
All PDFs of this category
1043
The Rings Go Marching Two by Two
1044
Synthesis of Ixene and its BN Analogue: Teaching an Old Molecule New Tricks
1045
A Facile Route to Scalable Production of Functional Polymers Derived from Biomass
1046
Turn-off Fluorescent Photoswitches Based on Norbornadiene-Bridged Diarylethenes
1047
Once in a Blue Moon Molecule: Azulene-Embedded Bisimide with Retention of Original Aromatic Character
1048
Perylene Bisimides Dye the Knot
1049
A New Path to Dibenzocyclooctaphenanthrenes
1050
Visible-Light-Mediated Synthesis of AzaBenzannulated Perylenediimides
1051
Fluorines in Coumarins for Long Wavelength Emissions
1052
Domino Annulation using Biradical Character
1053
(air)BNB Open for Phenalene Business
1054
Charged Charges: Zwitterionic Primary Explosives

Metals in Synthesis

z1055
All PDFs of this category
1055
Titanium-Catalyzed Oxidative Amination Using Diazenes
1056
A Mild Iridium-Catalyzed Asymmetric Hydrogenation of Oximes
1057
Synthesis of β-Amino Alcohols by Visible-Light-Assisted Intramolecular Copper-Catalyzed C–H Amination
1058
Rhodium-Catalyzed Annulation of 3-Aryl-2H-benzo[b][1,4]oxazines and Alkynes via C–H Activation
1059
Synthesis of Borylated Phosphoarenes
1060
Rhodium-Catalyzed Three-Component Annulation for the Synthesis of Highly Substituted Dihydropyrans
1061
Copper-Catalyzed Blue-Light-Mediated Olefination from Alkynes and Aldehydes
1062
Magnesiation of Aryl Fluorides
1063
Preparation of Chiral Allenylic Amines
1064
Iridium-Catalyzed Site-Selective C–H Activation/Amination of Disubstituted Alkenes
1065
Iridium Photoredox Catalyzed Generation of Dialkyl Sulfones
1066
Synthesis of Silicon-Stereogenic Silanes via Enantioselective Si–H Insertion
1067
Dual Nickel/Photoredox Catalytic Cross-Electrophile Coupling
1068
Cobalt-Catalyzed Formation of Five-Membered Rings from 1,6-Enynes via Hydroacylation
1069
Photocatalyzed Preparation of Ketones from Carboxylic Acids
1070
Amine Functionalization via Iridium Photocatalysis
1071
Nitroarenes as Building Block for Carbohelicenes
1072
Pd-Catalyzed Diastereoselective Ring-Opening of Vinyl Cyclopropanes Creating Distant (1,5) Stereocenters
1073
Synthesis of Di- and Tri-fluorinated Alkyl, Allylic and Homoallylic Alcohols by a Radical Cascade Sequence
1074
Palladium-Catalyzed Cross-Coupling of Pyridyl Phosphonium Salts and Aryl Halides
1075
Palladium-Catalyzed Dearomative 1,4-Difunctionalization of Naphthalenes
1076
Nickel-Dipyrrin Complex Catalyzed Intramolecular C(sp3)–H Bond Amination
1077
Hydrocyanation Enabled by Copper and Cobalt Dual Electrocatalysis
1078
Asymmetric Reductive and Alkynylative Heck Bicyclization of Enynes
1079
Asymmetric Vinylogous anti-Addition of Butenolides to Chromones
1080
Palladium-Catalyzed Cross-Coupling of Alkenyl Carboxylates
1081
Preparation of Amides via Intermolecular Dehydrogenative Coupling of Alcohols with Amines
1082
Enantioselective Alkynylation of Benzylic C–H Bonds

Polymer-Supported Synthesis

z1083
All PDFs of this category
1083
Regulation of Catalytic Activity in Hydrogenation with Platinum Nanoparticles in a PS-PEG Matrix
1084
Oxidative Cyanation of Alcohols on Atomically Dispersed Ruthenium Supported on MnO2Nanorods
1085
α-Arylation of Nitriles Catalyzed by Palladium Nanoparticles in Proline-Based Micelles
1086
The Sonogashira Reaction Using Pd/Cu Bimetallic Nanoparticles Supported on Graphene Oxide
1087
C–H Arylation of Furan and Thiophene by Using a Black Phosphorus Photoredox Catalyst
1088
Aerobic C–H Oxidation of Alkylbenzenes on Vanadium Supported on SiO2@Fe3O Nanoparticles in Water
1089
C–H Arylation of 1,2,3-Triazoles on a Pd/C Catalyst
1090
Oxidative Carbonylation of Allene Amides on Pd Supported on Amino-Functionalized Nanocellulose
1091
Carbon–Sulfur Cross-Coupling Catalyzed by Dendritic-Polymer-Supported Palladium Nanoparticles
1092
Photodehydrogenation of N-Heterocycles Catalyzed by Titania-Supported Rhodium Nanoparticles

Organo- and Biocatalysis

z1093
All PDFs of this category
1093
Identification of the First Stand-Alone Intermolecular Diels–Alderase
1094
Hypoiodite Catalysis Permits a General Oxidative Azidation of 1,3-Dicarbonyl Compounds
1095
Iodine-Catalyzed Photochemical C(sp3)–H Fluorination Using Nucleophilic Fluorine
1096
Organic Photoredox-Catalytic Oxidative Fluorination of Strained Cycloalkylbenzamides
1097
Bis-thiourea Permits Highly Selective β-Glycosylation of Acetonide-Protected Glycosyl Donors
1098
Enantioselective Synthesis of γ-Substituted Enones by a Catalytic 1,3-Prototropic Shift
1099
Bisurea-Catalyzed Enantioselective Synthesis of γ-Fluoroamines
1100
Photoenzymatic Catalysis Permits New-to-Nature Enantioselective Hydroalkylation
1101
Photooxygenation of Tetrahydrocarbazoles: Synthesis of Uncommon C,N-Diacyliminium Ion Precursors
1102
A New Organic Visible-Light Energy-Transfer Catalyst

Chemistry in Medicine and Biology

z1103
All PDFs of this category
1103
Selective Activation of Protein Phosphatase 2A Complexes
1104
Dexamethasone – A Corticosteroid Reduces Death in Severe COVID-19
1105
Design and Synthesis of Antiviral Drug Candidates Targeting SARS-CoV-2 Main Protease
1106
A Potent and Selective Covalent Inhibitor of Pin1
1107
Membrane Photoswitches on Neuronal Fire
1108
SCH79797: A Two-For-One Deal
1109
An Eight-Step Synthesis of Islatravir
1110
Photoredox Conjugate Addition Allows Access to a New Class of LRH-1 Agonists
1111
Cobalt-Catalyzed Asymmetric Hydrogenation of α,β-Unsaturated Acids
1112
The Gram-Negative Upgrade for Ribocil C
1113
A Toxic RNA Makes Its Own Fluorescent Inhibitor
1114
Chemoselective Cross-Coupling Reactions on Pyridine Derivatives

Peptide Chemistry

z1115
All PDFs of this category
1115
An N-Protecting Group for Solid-Phase Peptide Synthesis in Aqueous Media
1116
Enantioselective Synthesis of Proline Derived Bicyclics
1117
Palladium-Catalyzed Peptide Macrocyclization
1118
Copper-Catalyzed 1,3-Dipolar Cycloaddition of Glycine Imino Esters
1119
Alkylation of Glycine Derivatives to Access Nonnatural Amino Acids
1120
Decarboxylative Synthesis of α-Amino Acids from Malonates
1121
Ni/Cu-Catalyzed Synthesis of α-Quaternary Amino Acid Derivatives
1122
Stereodivergent Synthesis of Serine and Cysteine Derivatives by Copper/Iridium Catalysis
1123
Palladium-Catalyzed γ-C(sp3)–H Bond Arylation of Amino Esters
1124
Palladium-Catalyzed C–H Bond Vinylation of Amino Acids and Peptides
1125
A Novel Reagent for tert-Butoxycarbonylation of Amino Acids

Flow Chemistry

z1127
All PDFs of this category
1127
C–H Activation of Gaseous Alkanes
1128
Design of Flow Reactor for Efficient Kinetic Analysis
1129
Protein Synthesis on Demand, and Make it Snappy!
1130
Photocatalytic α-Tertiary Amine Synthesis via C–H Alkylation of Primary Amines
1131
Biocatalytic Reduction of Keto Esters and Heterocyclic Ketones in Continuous Flow
1132
Nonactivated C–H Methylation with Methanol by Using a Gallium Nitride Photocatalyst