DOI: 10.1055/s-00000131

Synfacts

Issue 09 · Volume 15 · September 2019 DOI: 10.1055/s-009-43957

Synform

A132
Zanda, Matteo: SYNFORM ISSUE 2019/09

Synthesis of Natural Products and Potential Drugs

z0963
All PDFs of this category
0963
Enantioselective Synthesis of Arcutinidine, Arcutinine, and Arcutine
0964
Synthesis of a CGRP Receptor Antagonist
0965
Synthesis of Tucatinib
0966
Synthesis of Pexidartinib
0967
Synthesis of MK-8150
0968
Synthesis of (±)-Arcutinidine
0969
Enantioselective Total Synthesis of (–)-Arcutinine
0970
Total Synthesis of Conidiogenone Natural Products
0971
Synthesis of (+)-Aquatolide
0972
Synthesis of an Indoleamine-2,3-dioxygenase-1 Inhibitor
0973
Synthesis of (±)-Idarubicinone
0974
Synthesis of PF-06815345
0975
Synthesis of a BACE1 Inhibitor
0976
Synthesis of PF-06372865
0977
Synthesis of Eliglustat
0978
Synthesis of (±)-Cocaine

Synthesis of Heterocycles

z0979
All PDFs of this category
0979
Photoredox Fischer Indole Synthesis
0980
Three-Component Synthesis of Diazacycles
0981
Photocatalytic Synthesis of N-Heterospirocycles
0982
Synthesis of (5+5)-Annulated Heteroaromatics
0983
Electrochemical C–H Amination of Quinoxalinones
0984
Stereoselective Synthesis of Chiral Isoxazole-dispirobisoxindoles
0985
Triflic Acid-Mediated Synthesis of (Z)-β-Enamido Triflates and Fluorosulfonates
0986
Synthesis of Indolizines from 2-(Propargyloxy)pyridines and Methyl Ketones
0987
Directing-Group-Free C7-Alkylations of N-Alkylindoles by Zirconium Complexes
0988
2,2-Disubstituted Tetrahydrofurans through [4+1] Cyclization
0989
1,3-Dipolar Cycloaddition to Access Spirocyclic Nitrochromene Derivatives
0990
Heteroarenes by Regioselective C–H Activation of Phenol and Aniline Derivatives
0992
Semisaturated Diazoheterocycles through N–N Bond Formation

Synthesis of Materials and Unnatural Products

z0993
All PDFs of this category
0993
Reaching the APEX in Controlled Synthesis of 2D Nanomaterials
0994
New Kid on the Block with Switchable Catalysis
0995
Synthesis of a Hydrophilic Trityl Radical
0996
A Diquat-Containing Macrocycle for Recognizing Anions
0997
Slam Dunk or Lay-Up? Synthesis of Large Flexible Carbon Nanohoops using Hexa-peri-hexabenzocoronene
0998
One-Pot, Three-Component Access to 1,2,3-Thiadiazoles
0999
Unsymmetrical Cyclophanes Romp through Well-Defined Donor–Acceptor Polymers
1000
One Step Closer to Carbynes and Polyynes by Ball Milling
1001
Sequencing Graphene Nanoribbons
1002
Stability is Key for the Tetrabenzopentacene Well-BN
1003
Easy Access to Triazolophenanthridines
1004
A Rearranging Helical Quinone

Metals in Synthesis

z1005
All PDFs of this category
1005
Rhodium(III)-Catalyzed Asymmetric Synthesis of Axially Chiral Biindolyls
1006
Enantioselective Cross-Coupling of α-Bromo Carboxamides
1007
Chiral 2,2-Disubstituted Tetrahydrofurans and Tetrahydropyrans
1008
Arylation of Phosphorothiates via Dinuclear Palladium(I) Catalysis
1009
Rhodium-Catalyzed Hydroallylation of Vinylarenes and 1,3-Dienes
1010
Palladium-Catalyzed Synthesis of anti-1,3-Amino Alcohols
1011
Enantioselective Borylacylation of 1,1-Disubstituted Allenes
1012
Enantioselective Borylcyanation of 1-Aryl-1,3-butadienes
1013
Enantioselective Simmons–Smith Cyclopropanation: The Charette Modification
1014
Accessing α-Vinyl Aldehydes through a Push–Pull Strategy
1015
Mn/Fe Catalyzed Hydrogen Atom Transfer (HAT) Reactions for the Preparation of N‑Heterocycles
1016
Silicon-Atom-Bound Methyl C(sp3)–H Bond Arylation and Amidation
1017
Reductive Intermolecular Coupling of Dienes and Aldehydes
1018
Palladium-Catalyzed C(sp3)–H Olefination
1020
The Organolithium Dictates the Chemoselectivity
1021
Gold-Catalyzed Cyclization of 1,7-Enynes
1023
HCN-Free Hydrocyanation of Alkenes
1024
Asymmetric 1,4-Addition of Silicon Nucleophiles
1026
Iridium-Catalyzed Direct Olefin Difunctionalization
1027
Quaternary Centers via Transnitrilation
1028
Argentination of Fluoroform
1029
The Rhodium-Catalyzed Asymmetric 1,4-Addition
1030
Bpin-Directed Nickel-Catalyzed Hydrocarbonation
1031
Iridium-Catalyzed Enantioselective C(sp3)–H Borylation of Cyclopropanes
1032
Calcium-Catalyzed Enantioselective Friedel–Crafts Alkylation of Indoles
1033
Palladium-Catalyzed Enantioselective Amino- and Carboboration of Alkenes

Polymer-Supported Synthesis

z1035
All PDFs of this category
1035
Photocatalytic 1,2-Formylarylation of N-Arylacrylamides
1036
Cycloaddition of Epoxides with CO2 on a Brominated Layered Double Hydroxide
1037
Nanoparticulate Gold Catalyzed Controlled Reduction of Nitroarenes
1038
Ullman Reaction on N-Doped Carbon Black-Supported PdAu Nanoparticles
1039
Suzuki–Miyaura Coupling on Salicylaldehyde-Stabilized Palladium Nanoparticles
1040
Intramolecular Hydroamination of Alkynylanilines on MOF-Supported Zinc(II)
1041
Carboxymethylation of Alcohols Catalyzed by NZSM-5 Zeolite
1042
Decarboxylative Sulfonylation of Cinnamic Acids on Polystyrene-Supported Rose Bengal
1043
Kaolin-Based Nanocatalyst for the Synthesis of Pyrimido[2,1-b]benzothiazoles
1044
α-Methylation of Ketones Catalyzed by Nickel Supported on Silica–Alumina
1045
Palladium-Catalyzed Cross-Coupling Reaction of Heteroaryl Esters
1046
Suzuki–Miyaura Coupling Catalyzed by a Nickel-Metalated Porous Organic Polymer

Organo- and Biocatalysis

z1047
All PDFs of this category
1047
(5+1) Annulations through Double Umpolung of Conjugate Acceptors
1048
Photoredox [4+2] Annulation to Construct Substituted Benzene Rings
1049
Catalytic Friedel–Crafts Conjugate Addition/Enantioselective Protonation
1050
Directed Evolution Enables Direct C(sp3)–H Fluoroalkylation
1051
Positioning-Group-Enabled Biocatalytic Oxidative Dearomatization
1052
Protein Engineering Enables Stereodivergent Cyclopropanation
1053
Visible-Light-Induced Organocatalytic Borylation of Aryl Chlorides
1054
Organocatalytic Biomimetic Synthesis of 4-Arylquinolizidine Alkaloids
1055
Atroposelective Cyclodehydration Enabled by Disparate Catalytic Scaffolds
1056
The Stetter Reaction
1057
Carbon Dioxide-Catalyzed Michael-Type Cyanation of Coumarin Derivatives

Chemistry in Medicine and Biology

z1059
All PDFs of this category
1059
Palladium-Catalyzed Synthesis of Pyrimidine Nucleoside Analogs
1060
Efficient Synthesis of the Heparin Anticoagulant Idraparinux
1061
Late-Stage 18F Incorporation with Photoredox Catalysis
1062
A Small-Molecule Inhibitor of C5 Complement Protein
1063
Synthesis of Fluorinated Nucleoside Analogs with Antiviral Activity
1064
A Sensor for Attomolar Copper Levels
1065
Extreme Sulfur Species Mediate Cellular Uptake
1066
A Fluorescent Probe for Thioredoxin Reductase
1067
The First Total Synthesis of Artemisinin (Qinghaosu)
1068
A Hydrolytically Stable Analog of Decitabine
1069
Visualizing Prostate Cancer with Activatable Fluorophores
1070
Chemical Protein Degradation Targeting Non-Functional Binding Sites

Peptide Chemistry

z1071
All PDFs of this category
1071
Palladium-Catalyzed Synthesis of Cyclophane-Braced Peptide Macrocycles
1072
Cyclic β-Amino Acid Synthesis by Rhodium Catalysis
1073
Synthesis of Cyclic Peptides by the Peptide Claisen Rearrangement
1074
Manganese(I)-Catalyzed C–H Glycosylation of Amino Acids and Peptides
1075
Enantioselective Synthesis of β-Amino Alcohols by Palladium Catalysis
1076
Synthesis of β2-Aryl Amino Acids with Palladium Catalysts
1077
Tandem N,N-Dialkylation Reaction to Synthesize α-Amino Acid Derivatives
1078
Reductive Radical Cyclization of Tyrosine and Phenylalanine with Alkenes
1079
Synthesis of β-Nitro α-Amino Carboxylic Acids by an Aza-Henry Reaction
1080
Biocompatible Macrocyclization of Peptides
1081
Palladium-Catalyzed Cross-Coupling for the Synthesis of Fluorinated Amino Acids

Flow Chemistry

z1083
All PDFs of this category
1083
Ruthenium-Catalyzed Continuous-Flow Photochemical Alkoxylation of Styrenes
1084
Palladium-Catalyzed Diazo Cross-Couplings
1085
Synthesis of a Moxifloxacin Fragment
1086
Synthesis of Hydroquinones through Sequential and Continuous-Flow Hydrogenation-Derivatization
1087
Visible-Light-Promoted Iron-Catalyzed Cross-Coupling in Flow
1088
Chemo-Enzymatic Baeyer–Villiger Oxidation in Continuous Flow