DOI: 10.1055/s-00000131

Synfacts

Issue 10 · Volume 14 · October 2018 DOI: 10.1055/s-008-41480

Synform

A153
Zanda, Matteo: SYNFORM ISSUE 2018/10

Synthesis of Natural Products and Potential Drugs

z0999
All PDFs of this category
0999
Synthesis of a Phosphoinositide 3-Kinase (PI3K) β Inhibitor
1000
Synthesis of (–)-Dendrobine, (–)-Mubironine B, and (–)-Dendroxine
1001
Asymmetric Total Synthesis of (+)-Aplysiasecosterol A
1002
Synthesis of (–)-Septedine
1003
Synthesis of AZD1656
1004
Synthesis of (+)-Cyclocitrinol
1005
Synthesis of (–)-Xishacorene B
1006
Synthesis of BMS-978587
1007
Synthesis of QCA570
1008
Total Synthesis of (–)-Cycloclavine
1009
Synthesis of Esomeprazole
1010
Synthesis of GDC-0853
1011
Synthesis of OV329
1012
Total Synthesis of (–)-Actinophyllic Acid

Synthesis of Heterocycles

z1013
All PDFs of this category
1013
Synthesis of Enantioenriched 1H/3H-Pyrroles and Pyrroloimidazoles
1014
Indolo[3,2-c]coumarins and Benzofuro[3,2-c]quinolinones
1015
Synthesis of Trifluoromethylated Pyrrolidine and Piperidine Amino Acids
1016
Hypervalent Iodine Reagent for the Synthesis of 2-Substituted Indoles
1017
Phosphonium Salts as Surrogates for Aromatic Carbon–Heteroatom Bond Formation
1018
Scalable Synthesis of an exo-Triazolylazabicycle
1019
Synthesis of Cyclic Ureas by a Cross-Metathesis/Aza-Michael Sequence
1020
Synthesis of Quinolines through Double-Oxidative Dehydrogenative Cyclization
1021
C5 Alkenylation of Imidazoles and the Synthesis of Benzimidazoles
1022
Palladium-Mediated Stereoselective Synthesis of 3,4-Fused Indolines
1023
Samarium(II) Iodide Mediated Synthesis of Five- and Six-Membered N-Heterocycles
1024
Silver-Mediated Synthesis of Fluorinated Oxazolidinones
1025
C4-Activated Arylation of Pyrrolidines and Piperidines
1026
Pyranopyrimidine–Triazole Hybrid Molecules
1027
Quinoline-4-carboxylic Acids and Esters from N,N-Dimethylenaminones and Isatins

Synthesis of Materials and Unnatural Products

z1029
All PDFs of this category
1029
Lucky Seven-Membered Rings in N-Doped Nonplanar Nanographenes
1030
One-Step Yamamoto Coupling of Benzophenes and Cyclooctatetraenes
1031
Counting Up: One-, Two-, and Three-Boron Fused Oligo-Naphthalenes
1032
No Rotation Allowed: Triply Fused Porphyrin–Nanographene Conjugates
1033
All About That Strain: C–C Bond Activations of Cycloparaphenylenes by a Pt Complex
1034
So Retro: Synthesis of Tribenzocarbazoles from Azapropellanes
1035
To [n]Acenes and Beyond!
1036
New End-Capping System for Solution-Processable Oligothiophenes
1037
The Ramberg–Bäcklund Reaction Applied to Poly(arylene Vinylene) Synthesis
1038
Diastereocontrol by Blocking Nitrogen Inversion in a Quinolino[3,2,1-k]Phenothiazine
1039
Möbius Molecules
1040
Flexibility in Macrocycles is Key for Better Electron Transport

Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions

z1041
All PDFs of this category
1041
Asymmetric Decarboxylative Allylic Alkylation of Acyclic Enol Carbonates
1042
Enantioselective Scandium-Catalyzed Formal [4+2] Cycloaddition
1043
Enantioselective Intermolecular Ruthenium-Catalyzed Cycloaddition
1044
Iridium-Catalyzed Reductive Coupling of Allyl Acetates with Ynals
1045
C2-Symmetric Chiral Biscyclosulfinamide–Olefin Ligand
1046
Scandium-Catalyzed Enantioselective Ring-Opening of Cyclopropyl Ketones with Indoles
1047
Asymmetric Synthesis of 2,2,3-Trisubstituted Indolines
1048
Ytterbium-Catalyzed [4+2] Cycloaddition of Cyclobutenones with α-Keto Esters
1049
Copper-Catalyzed Asymmetric Synthesis of Spirocyclic β-Lactams
1050
Oxaspirocyclic Ligands for Iridium-Catalyzed Asymmetric Reduction
1051
Enantioselective Ruthenium(II)-NHC Catalyzed Hydrogenation of 2-Oxazolones
1052
Copper-Catalyzed Synthesis of Enantioenriched 1,2-Hydroxyboronates
1053
Iridium/Copper-Catalyzed Asymmetric Radical Cyanoalkylation of Styrenes
1054
Palladium–Amine-Catalyzed Enantioselective α-Allylation of Ketones
1055
Cobalt-Catalyzed Enantioselective Nazarov Cyclization/Fluorination Cascade
1056
Enantioselective Synthesis of Spirooxindole-thiaindans by Cooperative Catalysis
1057
Gold-Catalyzed Stereoselective Synthesis of β-Fluoro Michael Acceptors
1058
Reductive Asymmetric Ring-Opening of Azabenzonorbornadienes
1059
Enantioselective Transfer Hydrogenation of Alkynyl Ketones
1060
Asymmetric Heck–Matsuda Carbonylation
1061
Fluoroalkylamines as Nucleophiles in Iridium-Catalyzed Ring Opening
1062
Palladium-Catalyzed Asymmetric [4+2] Cycloaddition
1063
Asymmetric Dearomative [3+2] Cycloaddition by Zinc Catalysis
1064
Catalytic Diastereoselective Multi-Component Cyclopropanation
1065
Palladium-Catalyzed Asymmetric Rearrangement of Allyl Enol Ethers
1066
Enantioselective Iridium-Catalyzed Vinylogous Allylic Alkylation of Coumarins
1067
Diastereoselective Intermolecular Semipinacol Rearrangement
1068
Rhodium-Catalyzed Asymmetric Synthesis of Tertiary α-Hydroxy Esters
1069
Enantioselecitve [3+2] Cycloaddition of Aurones with Isocyanoacetates
1070
Palladium-Catalyzed Enantioselective Allylic C–H Alkylation of 1,4-Pentadienes

Metal-Mediated Synthesis

z1071
All PDFs of this category
1071
Asymmetric Synthesis of Vinyl Aziridines
1072
Intramolecular Glycosyl Stille Cross-Coupling
1073
meta-Arylation of Fluoroarenes
1074
Redox-Neutral C–H Olefination Catalyzed by Manganese
1075
Direct Reaction of Grignard Reagents with Isocyanates in Flow
1076
Transition-Metal-Free Amination and Etherification of Aryl Alkyl Thioethers
1077
Iron–Nickel Dual-Catalytic Olefin Functionalization
1078
Mechanochemical Generation of Organozinc Compounds
1079
Copper-Catalyzed Trifluoromethylation of Alkyl Iodides
1080
Selective Monomethylation of Arylacetonitriles and Arylacetamides
1081
Cobalt-Catalyzed Ring-Opening Coupling of Cyclopropanols with Alkynes
1082
Copper Iminoarylsulfonate Complex Catalyzed Amination
1083
Diastereodivergent Hydroarylation of Terminal Alkynes
1084
Generation of Strained Azacyclic Allenes for Diels–Alder Cycloadditions
1085
Defluoroalkylation of gem-Difluoroalkenes via Zinc

Organo- and Biocatalysis

z1087
All PDFs of this category
1087
Dynamic Kinetic Resolution of Azlactones with a Chiral DMAP Catalyst
1088
Acid-Catalyzed Rearrangement of Hydroxylated Pinene Derivatives
1089
Activating Ketones with Low Catalyst Loadings of a Potent Chiral Lewis Acid
1090
Phosphoric Acid Catalyzed Aldehyde Addition to o-Quinone Methides
1091
Enantioconvergent Biocatalytic Redoxisomerization of Pyranones
1092
Triazolium-Salt-Catalyzed Dialkylation of Bisoxindoles
1093
Enzymatic Control of the Stereochemical Course of [4+2] Cycloaddition
1094
Chiral-Aldehyde-Catalyzed α-Functionalization of Glycine Esters
1095
Fluorobissulfonylmethyl Iodides as Lewis Acid Catalysts
1096
Biocatalytic Production of Linear α-Olefins from Carboxylic Acids

Polymer-Supported Synthesis

z1097
All PDFs of this category
1097
Formylation of Amines with CO2 Using a Polymeric Frustrated Lewis Pair
1098
Hf-Based Metal–Organic Framework-Catalyzed Aldol Condensation and Hydrogenation
1099
Amidation of Amines with Carboxylic Acids Catalyzed by a Metal–Organic Framework
1100
Transfer Hydrogenation of Nitroarenes on Carbon-Coated Cobalt Nanoparticles
1101
Photocatalytic Deoxygenation of Sulfoxides and Pyridine N-Oxides
1102
Cyclic Carbonates from CO2 and Epoxides on a Supported Imidazole Catalyst
1103
1,4-Addition of Grignard Reagents to Chalcones on MS 4Å-Supported CuCl2
1104
Suzuki–Miyaura Coupling on Water-Soluble Fullerene-Supported PdCl2
1105
Controlled Hydrogenation of Alkynes on Bimetallic Gold/Palladium Nanoparticles
1106
Ring-Opening Diborylation of Cyclopropanes on Nanoporous Gold
1107
Synthesis of Symmetric Carboxylic Anhydrides from Aldehydes on a Cu-MOF

Addendum

1108
Pupo, G.; Ibba, F.; Ascough, D. M. H.; Vicini, A. C.; Ricci, P.; Christensen, K. E.; Pfeifer, L.; Morphy, J. R.; Brown, J. M.; Paton, R. S.; Gouverneur, V.: Hydrogen-Bonding Phase-Transfer Catalyst Enabled Asymmetric Fluorination