Heterotopic ossification arising from an anterolateral thigh free flap donor site: a previously unreported phenomenon

Heterotopic ossification is defined as abnormal bone deposition within non-skeletal tissues. Although it is rare, it has been associated with a history of trauma and surgical interventions. Herein, we present the case of a 74-year-old male patient, who was referred to our specialist center with a high-grade myxofibrosarcoma affecting his left knee. After a multidisciplinary discussion, wide resection and reconstruction with a contralateral free anterolateral thigh (ALT) free flap were performed. A 25 × 12 cm flap was harvested and its donor site repaired using a split-thickness skin graft, followed by adjuvant radiotherapy.

Over the course of 9 months following radiotherapy, the patient slowly developed a painless swelling on his right thigh. On examination, he presented a hard, raised mass measuring 12 × 5 cm under the healed split-thickness skin graft on the ALT donor site ([Fig. 1]). The mass did not affect his mobility. Plain X-ray films ([Fig. 2A]) and a computed tomography scan ([Fig. 2B]) were obtained and evaluated by senior radiologists with experience in sarcoma surgery, who agreed that the findings were consistent with heterotopic ossification and that histological confirmation was not required. The patient was reassured, and no further surgical intervention was sought.

Fig. 1. Firm swelling at the proximal anterolateral thigh donor site.

Fig. 2. Heterotopic ossification (red arrow) at the right thigh anterolateral thigh donor site. (A) Plain X-ray film. (B) Computed tomography scan.

Heterotopic ossification of free fibula flap pedicles has been previously reported and thought to be related to periosteum retained along the pedicle [1]. Studies have also described the development of heterotopic ossification within the rectus sheath following the harvest of a free rectus abdominis flap for limb reconstruction [2], as well as within a temporalis flap for ear reconstruction [3]. To the best of our knowledge, heterotopic ossification arising at an ALT donor site has not been previously reported and we do not have an explanation for this phenomenon.

Notes

Ethical approval

As per the United Kingdom Health Research Authority guidelines, case reports do not require institutional review board approval. Written informed consent was obtained.

Patient consent

The patient provided written informed consent for the publication and the use of his images.

Author contribution

Conceptualization: F Marlborough, JE Berner, DB Saleh, M Ragbir. Data curation: F Marlborough. Methodology: JE Berner. Project administration: F Marlborough. Writing - original draft: F Marlborough, JE Berner, M Ragbir. Writing - review & editing: JE Berner, DB Saleh, M Ragbir.

Conflict of Interest

No potential conflict of interest relevant to this article was reported.

• References

• 1 Autelitano L, Colletti G, Bazzacchi R. et al. Ossification of vascular pedicle in fibular free flaps: a report of four cases. Int J Oral Maxillofac Surg 2008; 37: 669-71
• 2 Warr RP, Fitton AR, Dickson WA. et al. Ossification in the rectus sheath following free rectus flap. Br J Plast Surg 1999; 52: 663-4
• 3 Price GJ, Stewart KJ. Heterotopic ossification of a temporal fascial flap pedicle in ear reconstruction. J Plast Reconstr Aesthet Surg 2010; 63: e146-7

Publication History

Received: 22 November 2020

Accepted: 23 January 2021

Article published online:
19 March 2022