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CC BY-NC 4.0 · Arch Plast Surg 2012; 39(04): 322
DOI: 10.5999/aps.2012.39.4.322
Discussion

Comparision of Wound Healing Effect of Cellulose and Gelatin: An In Vivo Study

Tae Hyun Choi
Department of Plastic and Reconstructive Surgery, Seoul National University College of Medicine, Seoul, Korea
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I have read this paper interestingly. This topic is enough to arouse reader's interest.

After the bleeding is discontinued after applying hemostatic, hemostatic will be absorbed slowly. However during the absorption, it should not hinder wound healing. Therefore the comparison of hemostatic effect on wound healing seems to be important when surgeon choose the hemostatic. Therefore the purpose of this paper is valuable for publication.

However there are some shortcomings in this study. First, author's follow-up period was only 4 weeks. However, the gelatin is known to be usually absorbed after at least 6 weeks according to previous study [[1]]. Naturally remnant gelatin cause an inflammation, and reversely the inflammation is necessary for the gelatin to be absorbed. Therefore the follow up period should be more longer than at least 6 weeks.

Second, the model of wound healing do not seem to be proper. The authors use the muscle defect model among various wound healing models such as skin defect model, bone defect model, cartilage defect model, etc. The reason why the authors chose should be clarified. Moreover I think that the author should investigate the final results of wound healing such as the regeneration of muscle or its function.

Third, they evaluated the results not quantitatively, but qualiatively. Therefore the results do not seem to be scientific and it seems anecdotal.

Although there are above mentioned shortcomings, I would like to appreciate the authors's effort to make this study.


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Conflict of Interest

No potential conflict of interest relevant to this article was reported.

  • REFERENCES

  • 1 Cegielski M, Izykowska I, Podhorska-Okolow M. et al. Development of foreign body giant cells in response to implantation of Spongostan as a scaffold for cartilage tissue engineering. In Vivo 2008; 22: 203-206
    PubMedGoogle Scholar

Correspondence

Tae Hyun Choi
Department of Plastic and Reconstructive Surgery, Seoul National University College of Medicine
101 Daehank-ro, Jongno-gu, Seoul 110-744
Korea   
Telefon: +82-2-2072-1978   
Fax: +82-2-766-5829   

Publikationsverlauf

Eingereicht: 24. Juni 2012

Angenommen: 26. Juni 2012

Artikel online veröffentlicht:
01. Mai 2022

© 2012. The Korean Society of Plastic and Reconstructive Surgeons. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonCommercial License, permitting unrestricted noncommercial use, distribution, and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes. (https://creativecommons.org/licenses/by-nc/4.0/)

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  • REFERENCES

  • 1 Cegielski M, Izykowska I, Podhorska-Okolow M. et al. Development of foreign body giant cells in response to implantation of Spongostan as a scaffold for cartilage tissue engineering. In Vivo 2008; 22: 203-206
    PubMedGoogle Scholar

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