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Vet Comp Orthop Traumatol 2013; 26(01): 54-60
DOI: 10.3415/VCOT-11-08-0110
Original Research
Schattauer GmbH

Synovial fluid D-dimer concentration in horses with osteochondritis dissecans and osteoarthritis

T. Ribera
1   Servei de Cirurgia Equina, Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Spain
,
L. Monreal
2   Servei de Medicina Interna Equina, Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Spain
,
M. A. Delgado
2   Servei de Medicina Interna Equina, Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Spain
,
J. Ríos
3   Laboratory of Biostatistics & Epidemiology, Facultat de Medicina, Universitat Autònoma de Barcelona, and Statistics & Methodology Support Unit, IDIBAPS, Hospital Clínic, Barcelona, Spain
,
M. Prades
1   Servei de Cirurgia Equina, Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Spain
› Author Affiliations
Further Information

Publication History

Received 05 August 2011

Accepted 06 September 2012

Publication Date:
19 December 2017 (online)

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Summary

Objective: To assess the synovial fibrinolytic pathway activation in adult horses with developmental and degenerative arthropathies such as osteochondritis dissecans (OCD) and osteoarthritis (OA) by measuring synovial D-dimer concentrations.

Methods: Prospective observational clinical study of horses admitted for OCD or OA. Synovial fluid was collected during lameness examination or prior to the surgical procedure, and D-dimer concentration and routine synovial fluid analysis were performed.

Results: Fifty-eight horses (14 with OCD, 10 with OA and 34 controls) were included in this study. Synovial D-dimer concentrations of horses with OCD and OA were both higher when compared with controls, but were only significantly different in horses with OCD (p = 0.005). However, no statistical differences were observed when comparing synovial D-dimer concentrations from the OCD horses with the OA-affected horses (p = 0.444).

Clinical significance: Activation of coagulation and fibrinolysis play a role in the pathophysiology of equine OCD and OA.

Keywords

Synovial fibrinolytic activity - synovial D-dimer concentration - horse - osteochondritis dissecans - osteoarthritis
 

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