Characteristics of abdominal vein thrombosis in children and adults

Daniel Landi; Michele G. Beckman; Nirmish R. Shah; Paula Bockenstedt; Althea M. Grant; John A. Heit; Nigel S. Key; Roshni Kulkarni; Marilyn Manco-Johnson; Stephan Moll; Claire S. Philipp; Judith C. Andersen; Thomas L. Ortel

doi:10.1160/TH12-08-0568

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2013; 109(04): 625-632
DOI: 10.1160/TH12-08-0568

Blood Coagulation, Fibrinolysis and Cellular Haemostasis

Schattauer GmbH

Characteristics of abdominal vein thrombosis in children and adults

Daniel Landi

¹Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA

,

Michele G. Beckman

²Centers for Disease Control and Prevention, Atlanta, Georgia, USA

,

Nirmish R. Shah

¹Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA

³Division of Hematology, Duke University Medical Center, Durham, North Carolina, USA

,

Paula Bockenstedt

⁴Hematology Oncology, University of Michigan, Ann Arbor, Michigan, USA

,

Althea M. Grant

²Centers for Disease Control and Prevention, Atlanta, Georgia, USA

,

John A. Heit

⁵Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA

,

Nigel S. Key

⁸University of North Carolina, Chapel Hill, North Carolina, USA

,

Roshni Kulkarni

⁶Pediatrics & Human Dev., Michigan State University, East Lansing, Michigan, USA

,

Marilyn Manco-Johnson

⁷University of Colorado and Children’s Hospital, Aurora, Colorado, USA

,

Stephan Moll

⁸University of North Carolina, Chapel Hill, North Carolina, USA

,

Claire S. Philipp

⁹University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA

,

Judith C. Andersen

¹⁰Wayne State University, Karmanos Cancer Institute, Detroit, Michigan, USA

,

Thomas L. Ortel

³Division of Hematology, Duke University Medical Center, Durham, North Carolina, USA

› Author Affiliations

Abstract

Summary

The demographic and clinical characteristics of adults and children with lower extremity deep-vein thrombosis and/or pulmonary embolism (LE DVT/PE) may differ from those with abdominal vein thrombosis (abdominal VT). Abdominal VT can be a presenting sign of an underlying prothrombotic state, and its presence in the setting of known disease might have prognostic implications different from LE DVT/PE. This study describes clinical presentations of abdominal VT compared to LE DVT/PE in adults and children. We analysed prospec-tively-collected data from consecutive consenting patients enrolled in one of seven Centers for Disease Control and Prevention (CDC) funded Thrombosis and Hemostasis Network Centers from August 2003 to April 2011 to compare the demographic and clinical characteristics of adults and children with abdominal VT. Both adults and children with abdominal VT tended to be younger and have a lower body mass index (BMI) than those with LE DVT/PE. Of patients with abdominal V T, children were more likely to have inferior vena cava (IVC) thrombosis than adults. For adults with venous thromboembolism (VTE), relatively more women had abdominal VT than LE DVT/PE, while the proportions with LE DVT/PE and abdominal VT by sex were similar in children. Children with abdominal VT were more likely to have diagnosed inherited thrombophilia, while trauma was more common in children with LE DVT/PE. In conclusion, both children and adults with abdominal VT were younger with a lower BMI than those with LE DVT/ PE. Significant differences exist between children and adults in respect to abdominal VT compared to LE DVT/PE.

Disclaimer: The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention.

Keywords

Venous thromboembolism - deep venous thrombosis - paediatrics - abdominal vein thrombosis

Full Text

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