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Thromb Haemost 2011; 105(04): 730-732
DOI: 10.1160/TH10-10-0652
Letters to the Editor
Schattauer GmbH

Functional profile of the platelet P2Y12 receptor signalling pathway in patients with type 2 diabetes mellitus and coronary artery disease

Masafumi Ueno
1   University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA
,
José L. Ferreiro
1   University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA
,
Salvatore D. Tomasello
1   University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA
,
Davide Capodanno
1   University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA
,
Antonio Tello-Montoliu
1   University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA
,
Murali Kodali
1   University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA
,
Naveen Seecheran
1   University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA
,
Kodlipet Dharmashankar
1   University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA
,
Rana Alissa
1   University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA
,
Piera Capranzano
1   University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA
,
Bhaloo Desai
1   University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA
,
Ronald K. Charlton
2   Jacksonville Transplant Center – Shands Jacksonville; Jacksonville, Florida, USA
,
Theodore A. Bass
1   University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA
,
Dominick J. Angiolillo
1   University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA
› Author Affiliations
Further Information

Publication History

Received: 13 October 2010

Accepted after major revision: 10 January 2010

Publication Date:
28 November 2017 (online)

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  • References

  • 1 Angiolillo DJ, Fernandez-Ortiz A, Bernardo E. et al. Platelet function profiles in patients with type 2 diabetes and coronary artery disease on combined aspirin and clopidogrel treatment. Diabetes 2005; 54: 2430-2435.
    CrossrefPubMedGoogle Scholar
  • 2 Angiolillo DJ, Bernardo E, Ramírez C. et al. Insulin therapy is associated with platelet dysfunction in patients with type 2 diabetes mellitus on dual oral antiplatelet treatment. J Am Coll Cardiol 2006; 48: 298-304.
    CrossrefPubMedGoogle Scholar
  • 3 Geisler T, Anders N, Paterok M. et al. Platelet response to clopidogrel is attenuated in diabetic patients undergoing coronary stent implantation. Diabetes Care 2007; 30: 372-374.
    CrossrefPubMedGoogle Scholar
  • 4 Serebruany V, Pokov I, Kuliczkowski W. et al. Baseline platelet activity and response after clopidogrel in 257 diabetics among 822 patients with coronary artery disease. Thromb Haemost 2008; 100: 76-82.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 5 Angiolillo DJ, Shoemaker SB, Desai B. et al. Randomized comparison of a high clopidogrel maintenance dose in patients with diabetes mellitus and coronary artery disease: results of the Optimizing Antiplatelet Therapy in Diabetes Mellitus (OPTIMUS) study. Circulation 2007; 115: 708-716.
    CrossrefPubMedGoogle Scholar
  • 6 Angiolillo DJ. Antiplatelet therapy in diabetes: efficacy and limitations of current treatment strategies and future directions. Diabetes Care 2009; 32: 531-540.
    CrossrefPubMedGoogle Scholar
  • 7 Erlinge D, Varenhorst C, Braun OO. et al. Patients with poor responsiveness to thienopyridine treatment or with diabetes have lower levels of circulating active metabolite, but their platelets respond normally to active metabolite added ex vivo. J Am Coll Cardiol 2008; 52: 1968-1977.
    CrossrefPubMedGoogle Scholar
  • 8 Ferreira IA, Mocking AI, Feijge MA. et al. Platelet inhibition by insulin is absent in type 2 diabetes mellitus. Arterioscler Thromb Vasc Biol 2006; 26: 417-422.
    PubMedGoogle Scholar
  • 9 Angiolillo DJ, Fernandez-Ortiz A, Bernardo E. et al. Variability in individual responsiveness to clopidogrel: clinical implications, management, and future perspectives. J Am Coll Cardiol 2007; 49: 1505-1516.
    CrossrefPubMedGoogle Scholar
  • 10 Wallentin L, Varenhorst C, James S. et al. Prasugrel achieves greater and faster P2Y12 receptor-mediated platelet inhibition than clopidogrel due to more efficient generation of its active metabolite in aspirin-treated patients with coronary artery disease. Eur Heart J 2008; 29: 21-30.
    PubMedGoogle Scholar