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Thromb Haemost 2007; 98(05): 1139-1140
DOI: 10.1160/TH07-06-0423
Case Report
Schattauer GmbH

Delayed-onset heparin-induced thrombocytopenia, venous thromboembolism, and cerebral venous thrombosis: A consequence of heparin “flushes”

Majed A. Refaai
1   Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
,
Theodore E. Warkentin
2   Department of Pathology and Molecular Medicine and Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada
,
Michael Axelson
3   Department of Internal Medicine, Division of Hematology/Oncology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
,
Karen Matevosyan
1   Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
,
Ravindra Sarode
1   Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
› Author Affiliations
Further Information

Publication History

Received 22 June 2007

Accepted after revision 24 August 2007

Publication Date:
30 November 2017 (online)

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  • References

  • 1 Warkentin TE, Kelton JG. Temporal aspects of heparin- induced thrombocytopenia. N Engl J Med 2001; 344: 1286-1292.
    CrossrefPubMedGoogle Scholar
  • 2 Warkentin TE, Kelton JG. Delayed-onset heparininduced thrombocytopenia and thrombosis. Ann Intern Med 2001; 135: 502-506.
    CrossrefPubMedGoogle Scholar
  • 3 Rice L, Attisha WK, Drexler A. et al. Delayed-onset heparin-induced thrombocytopenia. Ann Intern Med 2002; 136: 210-215.
    CrossrefPubMedGoogle Scholar
  • 4 Warkentin TE, Bernstein RA. Delayed-onset heparin- induced thrombocytopenia and cerebral thrombosis after a single administration of unfractionated heparin. N Engl J Med 2003; 348: 1067-1069.
    CrossrefPubMedGoogle Scholar
  • 5 Heeger PS, Backstrom JT. Heparin flushes and thrombocytopenia. Ann Intern Med 1986; 105: 143.
    PubMedGoogle Scholar
  • 6 Doty JR, Alving BM, McDonnell DE. et al. Heparin- associated thrombocytopenia in the neurosurgical patient. Neurosurgery 1986; 19: 69-72.
    CrossrefPubMedGoogle Scholar
  • 7 Ling E, Warkentin TE. Intraoperative heparin flushes and subsequent acute heparin-induced thrombocytopenia. Anesthesiology 1998; 89: 1567-1569.
    CrossrefPubMedGoogle Scholar
  • 8 Muslimani AA, Ricaurte B, Daw HA. Immune heparin- induced thrombocytopenia resulting from preceding exposure to heparin catheter flushes. Am J Hematol 2007; 82: 652-655.
    CrossrefPubMedGoogle Scholar
  • 9 Rauova L, Zhai L, Kowalska MA. et al. Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: diagnostic and therapeutic implications. Blood 2006; 107: 2346-2353.
    CrossrefPubMedGoogle Scholar
  • 10 Hong AP, Cook DJ, Sigouin CS. et al. Central venous catheters and upper-extremity deep-vein thrombosis complicating immune heparin-induced thrombocytopenia. Blood 2003; 101: 3049-3051.
    CrossrefPubMedGoogle Scholar