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DOI: 10.1160/TH04-03-0171
Fibrinogen adsorption and platelet adhesion to metal and carbon coatings
Financial support: The authors gratefully acknowledge the support of this research by EPSRC(UK) grant GR/R315884/01Publication History
Received
19 March 2004
Accepted after resubmission
07 July 2004
Publication Date:
04 December 2017 (online)
![](https://www.thieme-connect.de/media/10.1055-s-00035024/200405/lookinside/thumbnails/10-1160-th04-03-0171-1.jpg)
Summary
In order to study the haemocompatibility of metal and carbon coatings, fibrinogen adsorption and platelet adhesion to various coatings have been investigated.Two metallic coatings titanium and zirconium, and two carbon coatings isotropic diamondlike and isotropic graphite-like coatings, were prepared by plasma vapour deposition onto stainless steel substrate. It has been shown that the adsorption of fibrinogen to metal and carbon coatings and its post-adsorptive transition are dependent on both the material properties and the fibrinogen environment. The adsorption of fibrinogen from human plasma on titanium and zirconium coatings is similar to that on uncoated stainless steel surface. Both carbon coatings adsorb much greater amount of fibrinogen from plasma, and fibrinogen retention by carbon surfaces is also greater than by metal surfaces. Increased numbers of adhered platelets have been found on both carbon coatings in comparison to the metal materials, although this does not correlate with the amount of adsorbed fibrinogen.
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