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Synfacts 2008(8): 0864-0864
DOI: 10.1055/s-2008-1078517
DOI: 10.1055/s-2008-1078517
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of β³-Amino Acid Derivatives via Co-Catalyzed Carbonylation of Oxazolines
C. M. Byrne, T. L. Church, J. W. Kramer, G. W. Coates*
Cornell University, Ithaca, USA
Further Information
Publication History
Publication Date:
23 July 2008 (online)
Significance
A novel stereospecific synthesis of 2-aryl-2-oxazin-6-ones via Co-catalyzed carbonylation of oxazolines is described. 4-Substituted oxazolines react with clean inversion and 5-substituted oxazolines with complete retention of the stereoinformation at the chiral center.