Am J Perinatol 2008; 25(3): 189-192
DOI: 10.1055/s-2008-1061499
© Thieme Medical Publishers

Plasma Exchange in a Case of Severe Factor X Deficiency in Pregnancy: Critical Review of the Literature

Giuseppe Chiossi1 , Joel A. Spero2 , Emmanuel J. Esaka1 , Kristin Novic1 , Jennifer U. Celebrezze1 , Steven H. Golde1 , Ronald L. Thomas1
  • 1Department of Obstetrics and Gynecology, Division of Maternal and Fetal Medicine, Allegheny General Hospital, Pittsburgh, Pennsylvania
  • 2Department of Human Oncology, Allegheny General Hospital, Pittsburgh, Pennsylvania
Further Information

Publication History

Publication Date:
29 February 2008 (online)

ABSTRACT

Hereditary factor X deficiency represents an uncommon challenge in pregnancy. A 30-year-old primigravida affected by severe factor X deficiency was followed from 6 weeks of gestation until delivery. Factor X was provided prior to delivery for the first time in pregnancy via plasma exchange. The pregnancy and postpartum period were not complicated by bleeding episodes; therefore this approach was accompanied by lower cost and fewer side effects when compared with fresh-frozen plasma and prothrombin complex concentrates infusion, two therapeutic options already used in pregnancy.

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Giuseppe ChiossiM.D. 

Department of Obstetrics and Gynecology, Allegheny General Hospital

7th Floor South Tower, 320 East North Avenue, Pittsburgh, PA 15212