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Am J Perinatol 1986; 3(3): 161-163
DOI: 10.1055/s-2007-999858
ORIGINAL ARTICLE

© 1986 by Thieme Medical Publishers, Inc.

Serum Creatine-Kinase-BB and Brain Damage in High-Risk Newborn Infants

Preliminary Study With A New Method For CK-BB EstimationM. Amato, R. Gambon, G. Von Muralt
  • Department of Perinatal Medicine, University Clinic of Obstetrics and Gynecology, Berne, Switzerland
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Publication Date:
04 March 2008 (online)

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ABSTRACT

CK-BB activity increases after hypoxic conditions associated with central nervous system disease. Fifty-four high-risk newborn babies were studied with serial measurements of CK-BB activities during the first 3 postnatal days. These values were correlated to their early neurologic outcome at 5 months of age. Data were carried out using a new and very sensitive method for estimating CK-BB activity and showed a good correlation between enzymatic values and the presence of persistent neurologic abnormalities (P < .05). We conclude that early CK-BB determinations can be used as indicator of neonatal brain damage.