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Synfacts 2007(12): 1303-1303
DOI: 10.1055/s-2007-991328
DOI: 10.1055/s-2007-991328
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York
Radical Carbohydroxylation of Olefins with Aryl Diazonium Salts and TEMPO
M. R. Heinrich*, A. Wetzel, M. Kirschstein
Technische Universität München, Garching, Germany
Further Information
Publication History
Publication Date:
22 November 2007 (online)
![](https://www.thieme-connect.de/media/synfacts/200712/lookinside/thumbnails/10.1055-s-2007-991328-1.jpg)
Significance
In this paper, the authors describe a synthetically highly useful and elegant method for an intermolecular radical coupling between diazonium salts and non-activated olefins. This reaction is well suitable for the straightforward synthesis of compounds belonging to various structural classes. The products can easily be reduced to alcohols, so that this reaction is a formal addition of an aryl and a hydroxyl group to a double bond, proceeding with a surprising generality.