Download PDF
Synfacts 2007(12): 1232-1232  
DOI: 10.1055/s-2007-991315
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Arglabin

Contributor(s): Philip Kocienski, Stewart Eccles
S. Kalidindi, W. B. Jeong, A. Schall, R. Bandichhor, B. Nosse, O. Reiser*
Universität Regensburg, Germany
Further Information

Publication History

Publication Date:
22 November 2007 (online)

    Permissions and Reprints

Significance

Arglabin is isolated from Artemisia glabella and shows good antitumor activity against various cell lines. This synthesis uses a highly diastereoselective γ-lactone cascade and a difficult stereoselective epoxidation to produce arglabin.