Solvent-Free Synthesis of β-Hydroxy Esters and β-Amino Esters by Indium-Mediated Reformatsky Reaction

Xi’an Chen; Changfu Zhang; Huayue Wu; Xiaochun Yu; Weike Su; Jiang Cheng

doi:10.1055/s-2007-990799

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Synthesis 2007(20): 3233-3239
DOI: 10.1055/s-2007-990799

PAPER

Solvent-Free Synthesis of β-Hydroxy Esters and β-Amino Esters by Indium-Mediated Reformatsky Reaction

Xi’an Chen^a, Changfu Zhang^a,b, Huayue Wu*^a, Xiaochun Yu^a, Weike Su*^a,c, Jiang Cheng^a
^a College of Chemistry and Materials Science, Wenzhou University, Wenzhou 325027, P. R. of China
Fax: +86(577)88368280; e-Mail: hywu3@163.com;
^b College of Life Science, Guizhou University, Guizhou 550025, P. R. of China
^c College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. of China

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Publication History

Received 20 June 2007
Publication Date:
21 September 2007 (online)

Abstract
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Abstract

In a convenient and efficient procedure for the solvent-free synthesis of β-hydroxy esters and β-amino esters, various aldehydes and aldimines undergo a Reformatsky reaction mediated by non-activated indium at room temperature to give the corresponding esters in good to excellent yields.

Key words

solvent-free - Reformatsky reaction - indium - β-hydroxy esters - β-amino esters

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For a review of the Reformatsky reaction, see ref. 1c.