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DOI: 10.1055/s-2007-977414
An Efficient New Synthesis of Racemic Cetiedil and a Novel Route to α-Ketocarboxylic Acids Utilising Mild Conditions
Publication History
Publication Date:
03 April 2007 (online)
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Abstract
We describe a new efficient synthesis of the prescribed racemic drug cetiedil [(±)-2-cyclohexyl-2-(3-thienyl)ethanoic acid 2-(hexahydro-1H-azepin-1-yl)ethylester]. Additionally, we report herein a high yielding large scale, route to its acid precursor 7, subsequently enabling large-scale synthesis of the chiral forms of cetiedil, and detailed pharmacological investigations.
Additionally, we describe a novel route to α-ketocarboxylic acids, starting from readily available or easily obtainable aldehydes: The mild conditions utilised opens up its applicability for use on molecules of biological interest.
Key words
cetiedil - enantiomers - synthesis - α-ketocarboxylic acids - Swern oxidation
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References and Notes
Current address: The Institute of Naval Medicine, Alverstoke, Gosport, Hants, PO12 2DL, UK.