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Synfacts 2007(9): 0974-0974  
DOI: 10.1055/s-2007-968816
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Pd(II)-Catalyzed Addition of Arylsiloxanes to α,β-Unsaturated Compounds in Water

Contributor(s): Paul Knochel, Tobias Thaler
R. Lerebours, C. Wolf*
Georgetown University, Washington, USA
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Publication History

Publication Date:
23 August 2007 (online)

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Significance

This addition reaction is remarkable in two ways: First, it can be carried out in water due to the high stability of the palladium-phosphinous acid catalyst and second, it includes the first examples of the Pd-catalyzed addition of arylsiloxanes to α,β-unsaturated esters and nitriles. The respective β-substituted products are obtained in good to excellent yields.