Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2007(6): 0581-0581
DOI: 10.1055/s-2007-968580
DOI: 10.1055/s-2007-968580
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart · New York
One-Pot Cu-Catalyzed Synthesis of 3-Substituted Indazoles
D. Viña, E. del Olmo*, J. L. López-Pérez, A. San Feliciano
CIETUS, Salamanca, Spain
Further Information
Publication History
Publication Date:
22 May 2007 (online)
Significance
A straightforward method for the synthesis of substituted indazoles and related heterocycles (Y = N) by a Cu-catalyzed coupling of 2-haloaryl ketones or 2-halobenzoic acids with hydrazines is described. 2-Haloaryl ketones give better yields than 2-halobenzoic acids which proceed poorly (16-26%). The functional group tolerance and scope of substrates were not well investigated.