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Synfacts 2007(6): 0607-0607
DOI: 10.1055/s-2007-968557
DOI: 10.1055/s-2007-968557
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
New Biferrocene P,P,O-Ligand
H.-L. Zhang, X.-L. Hou*, L.-X. Dai*, Z.-B. Luo
Shanghai Institute of Organic Chemistry, P. R. of China
Further Information
Publication History
Publication Date:
22 May 2007 (online)
![](https://www.thieme-connect.de/media/synfacts/200706/lookinside/thumbnails/10.1055-s-2007-968557-1.jpg)
Significance
The primary focus of this work is the synthesis of the new P,P,O-ligand 4 designed by Hou and Dai. To demonstrate its utility, it was applied to the asymmetric hydrogenation of ketones. Although the only substrates tested in this report were β-hydroxy ketones 1, the enantioselectivity obtained is high. Previous hydrogenation methods using Ru(II)/MeO-BIPHEP are excellent for alkyl ketones, but gave 95% ee with aryl ketones like 1 (P. Bertus et al. Tetrahedron Lett. 1999, 40, 3175-3178).