Planta Med 2007; 73(3): 289-292
DOI: 10.1055/s-2007-967107
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Alkaloids from Melochia chamaedrys

Gilvan O. C. Dias1 , Carla Porto1 , Caroline Z. Stüker1 , Vanessa Graessler1 , Robert A. Burrow1 , Ionara I. Dalcol1 , Ubiratan F. da Silva1 , Ademir F. Morel1
  • 1Departamento de Química, NPPN, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil
Further Information

Publication History

Received: September 1, 2006

Accepted: December 21, 2006

Publication Date:
12 March 2007 (online)

Abstract

Investigation of the chemical constituents from the roots of Melochia chamaedrys (Sterculiaceae) resulted in the isolation of two quinolinone alkaloids: a new alkaloid, named chamaedrone (1), and a known alkaloid, antidesmone (2). Their structures and stereochemistry were elucidated on the basis of 2D NMR and X-ray crystallographic analysis. Furthermore, alkaloids 1 and 2, and the synthetic analogues 3 - 6 obtained from 2, were screened for antimicrobial activities.

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Ademir F. Morel

Departamento de Química

NPPN

Universidade Federal de Santa Maria

97045-100 Santa Maria

RS

Brazil

Phone: +55-55-3220-8869

Fax: +55-55-3220-8031

Email: afmorel@base.ufsm.br