Horm Metab Res 2007; 39(1): 41-45
DOI: 10.1055/s-2007-957344
Original Clinical

© Georg Thieme Verlag KG Stuttgart · New York

Factors Responsible for Glucose Intolerance in Japanese Subjects with Impaired Fasting Glucose

M. Izuka 1 , M. Fukushima 1 , A. Taniguchi 2 , Y. Nakai 3 , H. Suzuki 1 , T. Kawakita 4 , S. Kawamata 5 , O. Kajimoto 6 , K. Tsuda 7 , N. Nagaki 8 , M. Murakami 1 , Y. Seino 2
  • 1Health Informatics Research Group, Translational Research Informatics Center, Foundation for Biomedical Research and Innovation, Kobe, Japan
  • 2Kansai-Denryoku Hospital, Osaka, Japan
  • 3Clinic Karasuma Oike Nakai Clinic, Kyoto, Japan
  • 4Department of Internal Medicine, Kyoto Preventive Medical Center, Kyoto, Japan
  • 5Translational Research Informatics Center, Foundation for Biomedical Research and Innovation, Kobe, Japan
  • 6Soiken Inc., Osaka, Japan
  • 7Laboratory of Metabolism, Kyoto University Faculty of Integrated Human Studies, Kyoto, Japan
  • 8Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Further Information

Publication History

Received 3. 4. 2006

Accepted 14. 8. 2006

Publication Date:
16 January 2007 (online)

Abstract

Impaired fasting glucose (IFG) represents risk of development of diabetes (DM) and its complications. We investigated insulin secretion and insulin sensitivity in 403 IFG subjects divided into three levels of 2-hour postchallenge glucose (2-h PG) to clarify the factors responsible in the development of glucose intolerance in Japanese IFG. Nearly 60% of the subjects at annual medical check-up with FPG of 6.1-7.0 mmol/l at the first screening were diagnosed by 75 g oral glucose tolerance test (OGTT) to have impaired glucose tolerance (IGT; FPG <7.0 mmol/l and 7.8 mmol/l <2-h PG <11.1 mmol/l) or DM (isolated postchallenge hyperglycemia (IPH); FPG <7.0 mmol/l and 11.1 mmol/l <2-h PG level). The primary factor in the decreased glucose tolerance was a decrease in early-phase insulin, with some contribution of increasing insulin resistance. In addition, IFG/IGT and IFG/IPH subjects showed a compensatory increase in basal insulin secretion sufficient to keep FPG levels within the non-diabetic range. IFG is composed of three different categories in basal, early-phase insulin secretion, and insulin sensitivity.

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Correspondence

M. Fukushima

Health Informatics Research Group, Translational Research

Informatics Center, Foundation for Biomedical Research and Innovation

1-5-4, Minatojima-minamimachi

Chuo-ku

Kobe

650-0047 Japan

Email: fukum@tri-kobe.org