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DOI: 10.1055/s-2007-957344
© Georg Thieme Verlag KG Stuttgart · New York
Factors Responsible for Glucose Intolerance in Japanese Subjects with Impaired Fasting Glucose
Publication History
Received 3. 4. 2006
Accepted 14. 8. 2006
Publication Date:
16 January 2007 (online)
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Abstract
Impaired fasting glucose (IFG) represents risk of development of diabetes (DM) and its complications. We investigated insulin secretion and insulin sensitivity in 403 IFG subjects divided into three levels of 2-hour postchallenge glucose (2-h PG) to clarify the factors responsible in the development of glucose intolerance in Japanese IFG. Nearly 60% of the subjects at annual medical check-up with FPG of 6.1-7.0 mmol/l at the first screening were diagnosed by 75 g oral glucose tolerance test (OGTT) to have impaired glucose tolerance (IGT; FPG <7.0 mmol/l and 7.8 mmol/l <2-h PG <11.1 mmol/l) or DM (isolated postchallenge hyperglycemia (IPH); FPG <7.0 mmol/l and 11.1 mmol/l <2-h PG level). The primary factor in the decreased glucose tolerance was a decrease in early-phase insulin, with some contribution of increasing insulin resistance. In addition, IFG/IGT and IFG/IPH subjects showed a compensatory increase in basal insulin secretion sufficient to keep FPG levels within the non-diabetic range. IFG is composed of three different categories in basal, early-phase insulin secretion, and insulin sensitivity.
Key words
impaired fasting glucose - impaired glucose tolerance - insulin secretion - insulin sensitivity - insulinogenic index
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Correspondence
M. Fukushima
Health Informatics Research Group, Translational Research
Informatics Center, Foundation for Biomedical Research and Innovation
1-5-4, Minatojima-minamimachi
Chuo-ku
Kobe
650-0047 Japan
Email: fukum@tri-kobe.org